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Method for preparing antibacterial traditional Chinese medicine preparation through folium artemisiae argyi extraction

A kind of Artemisia argyi extract and technology of Artemisia argyi, which is applied in the field of traditional Chinese medicine preparations, can solve the problems of large amount of solvent, long time, and the extract cannot comprehensively reflect the effect of medicinal materials, etc., and achieve the effects of controllable quality, simple process steps, and shortened refrigeration time

Inactive Publication Date: 2017-07-21
洛阳泽达慧康医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is also the problem of using large amounts of organic solvents
And immersion extraction usually requires a large amount of solvent and a long time
The low-polarity solvent extracts the low-polarity volatile oil components, while the water-soluble components are discarded, and the extracts cannot comprehensively reflect the effects of medicinal materials

Method used

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  • Method for preparing antibacterial traditional Chinese medicine preparation through folium artemisiae argyi extraction
  • Method for preparing antibacterial traditional Chinese medicine preparation through folium artemisiae argyi extraction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] A method for extracting and preparing traditional Chinese medicine antibacterial preparations from leaves of mugwort, comprising the following steps:

[0046] Step 1. Take the raw material of Artemisia argyi, place it in a pulverizer for coarse crushing, and obtain Artemisia argyi powder, inject steam into the Artemisia argyi powder, extract the volatile oil for 2 hours, collect the volatile oil, and obtain the Artemisia argyi substrate at the same time, and set aside;

[0047] Step 2, adding mass concentration to the Folium Artemisiae Argyi substrate is 20% ethanol solution, reflux extraction 2 times, the amount of ethanol solvent added each time is 8 times of the Folium Artemisiae Argyi substrate weight, and the extraction time is 1 hour;

[0048] Step 3, filter after the extraction is completed, and concentrate the filtrate under reduced pressure until the relative density is 1.05 to obtain a concentrated solution for future use;

[0049] Step 4: Use dilute hydrochlo...

Embodiment 2

[0053] A method for extracting and preparing traditional Chinese medicine antibacterial preparations from leaves of mugwort, comprising the following steps:

[0054] Step 1. Take the raw material of Artemisia argyi, place it in a pulverizer for coarse crushing, and obtain Artemisia argyi powder, inject steam into the Artemisia argyi powder, extract the volatile oil for 3 hours, collect the volatile oil, and obtain the Artemisia argyi substrate at the same time, and set aside;

[0055] Step 2, adding mass concentration to the Folium Artemisiae Argyi substrate is 20% ethanol solution, reflux extraction 4 times, the amount of ethanol solvent added each time is 10 times of the Folium Artemisiae Argyi substrate weight, and the extraction time is 1.5 hours;

[0056] Step 3, filter after the extraction is completed, and concentrate the filtrate under reduced pressure until the relative density is 1.06 to obtain a concentrated solution for future use;

[0057] Step 4: Use dilute hydro...

Embodiment 3

[0061] A method for extracting and preparing traditional Chinese medicine antibacterial preparations from leaves of mugwort, comprising the following steps:

[0062] Step 1. Take the raw material of Artemisia argyi, place it in a pulverizer for coarse crushing, and obtain Artemisia argyi powder, inject steam into the Artemisia argyi powder, extract the volatile oil for 5 hours, collect the volatile oil, and obtain the Artemisia argyi substrate at the same time, and set aside;

[0063] Step 2, adding mass concentration to the Folium Artemisiae Argyi substrate is 20% ethanol solution, reflux extraction 3 times, the amount of ethanol solvent added each time is 8 times of the Folium Artemisiae Argyi substrate weight, and the extraction time is 2 hours;

[0064] Step 3, after the extraction is completed, filter, and concentrate the filtrate under reduced pressure until the relative density is above 1, to obtain a concentrated solution for future use;

[0065] Step 4: Use dilute hyd...

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Abstract

The invention discloses a method for preparing an antibacterial traditional Chinese medicine preparation through folium artemisiae argyi extraction. The method comprises the following steps that 1, a folium artemisiae argyi raw material is taken and is put in a smashing machine for coarse smashing, steam is led to folium artemisiae argyi powder, volatile oil is extracted for 2-5 hours and is collected, and meanwhile a folium artemisiae argyi substrate is obtained; 2, an ethanol solution with the mass concentration of 20% is added into the folium artemisiae argyi substrate, and reflux extraction is performed; 3, filtration and concentration are performed after extraction is completed; 4, the pH of a concentrated solution is regulated to be 4-5, refrigeration is performed at the temperature of 0-4 DEG C for 2-4 days, and filtration is performed to obtain an extracted folium artemisiae argyi stock solution; 5, water is added to dilute the extracted folium artemisiae argyi stock solution, an organic solvent is dissolved in the volatile oil obtained in the step 1 through collection, namely preparation of the antibacterial traditional Chinese medicine preparation is completed. The steps of the method are simple, the cost is low, the operation is convenient, and the product containing volatile oil, flavone and other effective ingredients simultaneously is safely and efficiently obtained, and the liquid preparation is wide in application range and controllable and stable in quality and can be used for large-scale production.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a method for extracting and preparing traditional Chinese medicine antibacterial preparations from leaves of mugwort. Background technique [0002] Artemisia argyi L. is a perennial herb belonging to the genus Artemisia in the Asteraceae family, and is a commonly used medicinal plant. The leaves of mugwort for clinical application, that is, the leaves of mugwort. The application of mugwort leaves in our country has a very long history, which first appeared in the "Book of Songs" in BC. There are also records of Ai Ye in the classics of traditional Chinese medicine "Huang Di Nei Jing". According to the 2015 edition of "Chinese Pharmacopoeia", Artemisia argyi leaves warm the meridians to stop bleeding, dispel cold and relieve pain. External use for dispelling dampness and relieving itching; for vomiting blood, epistaxis, metrorrhagia, menorrha...

Claims

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Application Information

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IPC IPC(8): A61K36/282A61K9/08A61K47/46A61P31/04A61P11/06A61P11/14A61P11/10A61P7/04A61P7/02A61P29/00C11B9/02
CPCA61K9/08A61K36/282A61K47/46A61K2236/333A61K2236/37A61K2236/51A61K2236/53C11B9/025
Inventor 栾连军刘雪松荆海英孙彤刘永
Owner 洛阳泽达慧康医药科技有限公司