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Method for synthesizing calcium pyruvate based on mussel shell melanin separation

A technology of calcium pyruvate and mussel shells, applied in chemical instruments and methods, preparation of organic compounds, drug combinations, etc., can solve the problems of high prices and achieve significant inhibitory effects

Inactive Publication Date: 2017-08-04
QINGDAO UNIV
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  • Application Information

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Problems solved by technology

At present, there are few manufacturers in our country, and their products are mainly exported, and the price is expensive.

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  • Method for synthesizing calcium pyruvate based on mussel shell melanin separation

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[0015] Example: Wash 110kg of mussel shells and put them into a wet pulverizer for grinding (below 60 mesh), and process them with the water-flying method to obtain calcium source mussel shell powder (about 100kg in dry weight). Add 82kg of 98% pyruvic acid and 20kg of distilled water, stir, and filter after insulated at 60°C for 3 hours. (1) Wash the filter residue with tap water to neutrality, dissolve it with 30 liters of 0.5M sodium hydroxide and filter (filter residue recovery), Add 5 liters of 4M hydrochloric acid to the filtrate and then filter. The filter residue is washed with water to remove salt, deacidify (to neutral), and dry to obtain 390 g of mussel shell melanin; Dry at ~120°C to get calcium pyruvate [C 6 h 6 CaO 6 ] 97kg.

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Abstract

The invention relates to a method for synthesizing calcium pyruvate based on mussel shell melanin separation. The method comprises the steps of powder grinding, elutriation treatment, acidification conversion, filtration and purification. The method comprises the specific steps of scrubbing mussel shells, feeding to a wet pulverizer for grinding into powder (smaller than 60 meshes), and adding a proper amount of distilled water and pyruvic acid for conversion; filtering the mixture, carrying out alkali dissolution and acid precipitation treatment on filter residues, and washing and drying sediments to obtain mussel shell melanin; concentrating the filtrate in a vacuum concentration evaporator, crystallizing at 4 DEG C and drying at 100-120 DEG C to obtain calcium pyruvate. The separated mussel shell melanin has a significant inhibition effect on A-549 lung cancer cells and is expected to be developed into a natural antitumor drug, and calcium pyruvate is widely applied to the fields such as medicines and foods. The method is simple and convenient to operate, large-scale production, popularization and application are easy to achieve, and the high-valued comprehensive utilization of abundant mussel shell resources in China can be achieved.

Description

[0001] Technical field: [0002] The invention belongs to the technical field of high-value comprehensive utilization of shells, and in particular relates to a method for separating melanin and simultaneously synthesizing calcium pyruvate by using mussel shells. [0003] Background technique: [0004] Mussel (Mytilus edulis), the dried product is called mussel, is a kind of bivalve mollusk, and is one of the important cultured shellfish in my country. Mussels are easy to cultivate on a large scale because of their strong vitality. In Shandong, Guangdong, Liaoning, Hainan and other provinces in China, there are large areas of sea area used for mussel cultivation. In recent years, scholars at home and abroad have mainly focused on the edible part of mussels. Studies have shown that mussels have delicious meat and high protein content, so they have the reputation of "eggs in the sea", but there are relatively few studies on their shells. In fact, mussel shells are rich in natural...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/41C07C59/19A61K35/618A61P35/00C09B61/00
CPCA61K35/618C07C51/412C09B61/00C07C59/19
Inventor 魏玉西于佳胡迎芬
Owner QINGDAO UNIV
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