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A method for detecting formaldehyde content in hemodialysis concentrate packaging material

A technology of hemodialysis and detection method, applied in the field of analytical chemistry, it can solve the problems of potential risk of patients and human carcinogenicity, and achieve the effect of high-accuracy measurement and avoid pollution

Active Publication Date: 2019-07-23
QINGDAO PURUISEN MEDICINE SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And because the process of melting plasticizing and extruding the parison is a high-temperature process, high-density polyethylene may release some substances such as formaldehyde in the process, and formaldehyde can be carcinogenic to humans.
However, small molecular substances such as formaldehyde released during the high temperature process are likely to remain in high-density polyethylene barrels. Since formaldehyde is easily soluble in water, when high-density polyethylene barrels are used to pack hemodialysis concentrates, formaldehyde may migrate to Potential risk to patients when used in hemodialysis in concentrate
Yet so far there is no report about the detection method of formaldehyde content in the hemodialysis concentrate packaging material

Method used

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  • A method for detecting formaldehyde content in hemodialysis concentrate packaging material
  • A method for detecting formaldehyde content in hemodialysis concentrate packaging material
  • A method for detecting formaldehyde content in hemodialysis concentrate packaging material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Apparatus and conditions

[0065] Agilent 7890A gas chromatograph (equipped with FID detector); Chromatographic column: Agilent DB-FFAP, 60m×0.25mm, 0.50μm; Carrier gas flow rate: 1.5ml / min; Column temperature: starting temperature 60℃, maintain for 5 minutes, The temperature is increased to 175°C at a rate of 25°C per minute and maintained for 3.5 minutes; the injection port temperature is 150°C; the detector temperature is 200°C; the headspace bottle equilibrium temperature is 70°C, and the equilibrium time is 20 minutes; the sample volume is 1ml. The temperature of the headspace injection loop is 95°C, the temperature of the transfer line is 100°C, the injection pressure is 277kPa, and the injection pressure time is 1 minute.

[0066] Experimental steps

[0067] Cut the high-density polyethylene barrel of the hemodialysis concentrate packaging material into a certain size, into 0.5cm×0.5cm;

[0068] Wash the fragments of the high-density polyethylene bucket with soapy water...

Embodiment 2

[0073] Apparatus and conditions

[0074] Agilent 7890A gas chromatograph (equipped with FID detector); Chromatographic column: Agilent DB-FFAP, 60m×0.25mm, 0.50μm; Carrier gas flow rate: 1.5ml / min; Column temperature: starting temperature 60℃, maintain for 5 minutes, The temperature is increased to 175°C at a rate of 25°C per minute and maintained for 3.5 minutes; the injection port temperature is 150°C; the detector temperature is 200°C; the headspace bottle equilibrium temperature is 70°C, and the equilibrium time is 20 minutes; the sample volume is 1ml. The temperature of the headspace injection loop is 95°C, the temperature of the transfer line is 100°C, the injection pressure is 277kPa, and the injection pressure time is 1 minute.

[0075] Experimental steps

[0076] Cut the high-density polyethylene inner cover of the hemodialysis concentrate packaging material into a certain size, into 0.5cm×0.5cm;

[0077] Wash the high-density polyethylene inner cover fragments with soapy wa...

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Abstract

The invention discloses a method for detecting formaldehyde content in a hematodialysis concentrated solution packing material. According to the method for detecting the formaldehyde content in the hematodialysis concentrated solution packing material provided by the invention, the formaldehyde content is subjected to assay determination by adopting head space-gas chromatography. The test proves that the method is high in formaldehyde separation degree, high in sensitivity and high in specificity, the formaldehyde content is rapidly and accurately measured, and the method is suitable for quality control of possibly residual formaldehyde in hematodialysis concentrated solution packing materials such as a high-density polyethylene container and an inner cover. Specifically, the detection method comprises the following steps: (1) cutting a to-be-detected hematodialysis concentrated solution packing material into a certain size, and cleaning and airing; (2) performing water-curing treatment on the aired packing material in a closed container; and (3) performing headspace sampling on the soaking solution in the step (2) in a headspace bottle, and detecting the formaldehyde content by adopting gas chromatography.

Description

Technical field [0001] The invention relates to the technical field of analytical chemistry, in particular to a method for detecting formaldehyde content in a hemodialysis concentrate packaging material. Background technique [0002] Hemodialysis is one of the renal replacement treatments for patients with acute and chronic renal failure. It drains blood from the body to the body through a dialyzer composed of countless hollow fibers. The blood and the electrolyte solution containing the body's concentration are in and out of the hollow fibers. The substance exchanges through diffusion / convection to remove the body Metabolic waste, maintain electrolyte and acid-base balance; at the same time, remove excess water in the body; the electrolyte solution used in it is hemodialysis concentrate. Because it is in direct contact with human blood, the quality control of hemodialysis concentrate is very strict, not only required to contain Appropriate active ingredients (such as electrolyt...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/06G01N30/28G01N30/74
CPCG01N30/06G01N30/28G01N30/74
Inventor 李兴春叶晓燕张建勇李洁王康
Owner QINGDAO PURUISEN MEDICINE SCI & TECH CO LTD
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