Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Vegetable soft capsule composition not comprising chemical metal salts

A technology of chemical metal and soft capsules, applied in the field of vegetable soft capsule compositions that do not contain chemical metal salts

Active Publication Date: 2017-08-18
COSMAX BIO
View PDF5 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And, if you want to get close to soft capsules derived from plants in the market, it is not preferable to use chemical synthesis such as salts or buffers

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Vegetable soft capsule composition not comprising chemical metal salts
  • Vegetable soft capsule composition not comprising chemical metal salts
  • Vegetable soft capsule composition not comprising chemical metal salts

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0060] In order to set the amount of high-purity iota-carrageenan required for the gelation of wet films, after dissolution by concentration, the viscosity and gelation state were confirmed.

[0061] 1) Preparation method: After putting 0.5g of carrageenan into a 250ml beaker, fill it with purified water to prepare 100g, then stir, and raise the temperature to 80°C to completely hydrate. Viscosity and gelation state were confirmed after blending to 0.5 to 13% by weight at intervals of 0.5% by weight by the same method.

[0062] 2) Viscosity measurement method

[0063] (1) Viscometer: Brookfield DV-II+

[0064] (2) Conditions: LV3, LV4 (Spindle), 80°C, 20rpm

[0065] 3) Confirmation method of the gelation state: About 3 g of the hydrated solution was dropped on a stainless steel plate at a temperature of about 10°C. After 10 minutes of curing, when the reagent spoon is pressed about 2 mm and the pressure is released, the gel should not be applied to the spoon and the gel sho...

experiment example 2

[0072] In order to confirm the dissolving properties of the capsules in water after preparing soft capsules, after preparing wet films with varying concentrations of iota-carrageenan, the disintegration state was confirmed by drying. In the case of ordinary gelatin soft capsules, the amount of the powder component (gelatin) is about 40%, but the carrageenan of the present invention shows a sharp viscosity due to low-temperature purified water, so when the stirring motor of the film dissolution tank is considered A suitable amount of powdered ingredients is at the level of about 30% when loaded. After drying, the plasticizer which imparts elasticity to the film uses glycerin as in the gelatin soft capsule, and is set between 15% and 25% by weight, which is an amount generally used. As a solvent, purified water is set at about 45 to 55% by weight. In addition, in order to confirm the influence of the potassium salt and the sodium salt, an experiment was carried out by adding 1%...

experiment example 3

[0082] In order to confirm the compounding amount of iota-carrageenan and the sealing temperature of the soft capsule, a composition of the present invention (Example 3), a composition containing 6% or more of carrageenan (Comparative Example 1) and a sodium salt were prepared, respectively. Composition (comparative example 5), and utilize the soft capsule forming machine of common rotary mold mode to prepare soft capsule, thereby compared the quality of preparation procedure (dissolving time, bonding temperature) and soft capsule (disintegration, bonding rate and burst strength).

[0083] 1) Composition of coating solution

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Viscosityaaaaaaaaaa
Average molecular weightaaaaaaaaaa
Login to View More

Abstract

The present invention relates to a vegetable soft capsule composition not comprising chemical metal salts and, more particularly, to a vegetable soft capsule composition which comprises only 6 wt % or less of iota-carrageenan, which is an expensive vegetable gelling agent, such that, even without using chemical metal salts such as sodium salts or potassium salts, a capsule has no disintegration problem and a soft capsule can be adhered only by means of pressure and not heating. According to the present invention, preparation cost for a soft capsule is reduced by minimizing the amount of carrageenan, which is 10-20 times more expensive than starch (starch or modified starch), sodium (salts), which are a chemically synthesized product that causes adult diseases such as hypertension and heart diseases, are not used, and heat is not applied during adhesion (sealing), thereby preventing heat denaturation of active ingredients contained in the contents of the soft capsule.

Description

technical field [0001] The present invention relates to a plant-based soft capsule composition that does not contain chemical metal salts, more specifically, to a plant-based soft capsule composition that contains a small amount of high-priced plant-based soft capsules with a content of less than 6% by weight Even if the iota-carrageenan of the gel does not use chemical metal salts such as sodium salt or potassium salt, there is no disintegration problem of the capsule, and the soft capsule can be glued only by pressure without heating. Knot. Background technique [0002] A common method for preparing a soft gelatin capsule is as follows: after mixing predetermined amounts of gelatin, glycerin, and water, heating and dissolving at a temperature of 70 to 80° C. to prepare a coating solution. The coating solution is characterized in that it forms a semi-solid gel-form film at a temperature lower than about 35°C. The spreader box attached to the soft capsule molding machine f...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/48A61K47/36A61K47/30
CPCA61K9/48A61K47/30A61K47/36
Inventor 金东燮白周铉郑贤默李栽炫宣柱浩
Owner COSMAX BIO
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com