Vegetable soft capsule composition not comprising chemical metal salts

A technology of chemical metal and soft capsules, applied in the field of vegetable soft capsule compositions that do not contain chemical metal salts

Active Publication Date: 2017-08-18
COSMAX BIO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

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Method used

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  • Vegetable soft capsule composition not comprising chemical metal salts
  • Vegetable soft capsule composition not comprising chemical metal salts
  • Vegetable soft capsule composition not comprising chemical metal salts

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0059] Experimental example 1

[0060] In order to set the amount of high-purity iota-carrageenan required for the gelation of the wet film, the viscosity and the gelation state were confirmed after the concentration was dissolved.

[0061] 1) Preparation method: After putting 0.5 g of carrageenan in a 250 ml beaker, fill with purified water to prepare 100 g, then stir, and raise the temperature to 80° C. to complete hydration. After blending to 0.5 to 13% by weight at 0.5% by weight intervals by the same method, the viscosity and gelation state were confirmed.

[0062] 2) Viscosity measurement method

[0063] (1) Viscometer: Brookfield DV-II+

[0064] (2) Conditions: LV3, LV4 (Spindle), 80℃, 20rpm

[0065] 3) Method for confirming the gelation state: Drop about 3 g of the hydrated solution onto a stainless steel plate at a temperature of about 10°C. After curing for 10 minutes, when pressing about 2mm with the reagent spoon and releasing the pressing, the gel should not be applied to ...

Example Embodiment

[0071] Experimental example 2

[0072] In order to confirm the dissolving properties of the capsule in water after preparing the soft capsule, the concentration of iota-carrageenan was changed to prepare a wet film, and then drying was performed to confirm the disintegration state. In the case of ordinary gelatin soft capsules, the amount of the powder component (gelatin) is about 40%. However, the carrageenan of the present invention exhibits a sharp viscosity due to low-temperature purified water. Therefore, when considering the stirring motor of the film dissolving tank When loaded, the appropriate amount of the powder component is about 30% level. After drying, the plasticizer that imparts elasticity to the film uses glycerin in the same manner as the soft gelatin capsule, and is set between 15 to 25% by weight, which is a generally used amount. As the solvent, the purified water is set to be between about 45 to 55% by weight. In addition, in order to confirm the influence ...

Example Embodiment

[0081] Experimental example 3

[0082] In order to confirm the compounding amount of iota-carrageenan and the sealing temperature of the soft capsule, the composition of the present invention (Example 3), a composition containing 6% or more carrageenan (Comparative Example 1) and sodium salt were respectively formulated The composition (Comparative Example 5) was used to prepare soft capsules using a soft capsule molding machine in the usual rotating mold mode, so as to compare the preparation process (dissolution time, bonding temperature) and the quality of the soft capsule (disintegration, bonding Rate and rupture strength).

[0083] 1) Composition of coating solution

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Abstract

The present invention relates to a vegetable soft capsule composition not comprising chemical metal salts and, more particularly, to a vegetable soft capsule composition which comprises only 6 wt % or less of iota-carrageenan, which is an expensive vegetable gelling agent, such that, even without using chemical metal salts such as sodium salts or potassium salts, a capsule has no disintegration problem and a soft capsule can be adhered only by means of pressure and not heating. According to the present invention, preparation cost for a soft capsule is reduced by minimizing the amount of carrageenan, which is 10-20 times more expensive than starch (starch or modified starch), sodium (salts), which are a chemically synthesized product that causes adult diseases such as hypertension and heart diseases, are not used, and heat is not applied during adhesion (sealing), thereby preventing heat denaturation of active ingredients contained in the contents of the soft capsule.

Description

technical field [0001] The present invention relates to a plant-based soft capsule composition that does not contain chemical metal salts, more specifically, to a plant-based soft capsule composition that contains a small amount of high-priced plant-based soft capsules with a content of less than 6% by weight Even if the iota-carrageenan of the gel does not use chemical metal salts such as sodium salt or potassium salt, there is no disintegration problem of the capsule, and the soft capsule can be glued only by pressure without heating. Knot. Background technique [0002] A common method for preparing a soft gelatin capsule is as follows: after mixing predetermined amounts of gelatin, glycerin, and water, heating and dissolving at a temperature of 70 to 80° C. to prepare a coating solution. The coating solution is characterized in that it forms a semi-solid gel-form film at a temperature lower than about 35°C. The spreader box attached to the soft capsule molding machine f...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/36A61K47/30
CPCA61K9/48A61K47/30A61K47/36
Inventor 金东燮白周铉郑贤默李栽炫宣柱浩
Owner COSMAX BIO
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