Cosmetic composition for use on hair and containing an acyl basic amino acid derivative
一种组合物、化合物的技术，应用在含有效成分的医用配制品、化妆品、化妆品配制品等方向，能够解决亲和性差、没有被报道、化妆品失去光滑性等问题，达到增加毛发疏水性、降低角质层损伤的效果
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manufacture example 1
[0130] Manufacturing Example 1: Double (N ε -Synthesis of disodium salt of lauroyl-L-lysine) sebacamide
[0131] Will N ε -Lauroyl-L-lysine (8.2 g, 25 mmol) was dissolved in water (70 g), then 25% aqueous sodium hydroxide solution (10 g) and diethyl ether (80 g) were added. Sebacoyl chloride (3.3 g, 14 mmol) was slowly added to the ether layer. The bilayer solution was stirred while maintaining at 0°C for about 1 hour, then at room temperature for 23 hours. Then, 75% sulfuric acid was added dropwise to adjust the pH to 2, and the resulting white precipitate was collected by filtration, washed well with water and dried. The obtained compound was dissolved in aqueous sodium hydroxide solution to obtain 10% bis(N ε - lauroyl-L-lysine) sebacamide disodium salt solution.
manufacture example 2
[0132] Manufacturing Example 2: Double (N ε Synthesis of disodium salt of -octanoyl-L-lysine) sebacamide
[0133] Will N ε - Octanoyl-L-lysine (6.8 g, 25 mmol) was dissolved in water (70 g), then 25% aqueous sodium hydroxide solution (10 g) and diethyl ether (80 g) were added. Sebacoyl chloride (3.3 g, 14 mmol) was slowly added to the ether layer. The bilayer solution was stirred while maintaining at 0°C for about 1 hour, then at room temperature for 23 hours. Then, 75% sulfuric acid was added dropwise to adjust the pH to 2, and the resulting white precipitate was collected by filtration, washed well with water and dried. The obtained compound was dissolved in aqueous sodium hydroxide solution to obtain 10% bis(N ε -octanoyl-L-lysine) sebacamide disodium salt solution in water.
[0134] Double (N ε 1H-NMR of -octanoyl-L-lysine) sebacamide (free form)
[0135] 1H-NMR (400MHz, DMSO-d6, TMS, 25°C): δ0.85 (T, J=6.8Hz, 6H), 1.20-1.29 (m, 28H), 1.32-1.38 (m, 4H), 1.45- 1.50(...
Embodiment 1-7
[0136] [Example 1-7] [Comparative Example 1-4]: Preparation and evaluation of cosmetics for hair
[0137] Preparation of hair cosmetics of Examples 1-7 and Comparative Examples 1 and 2
[0138] The components of (I) described in Table 1 below were mixed, heated to 80-85° C., and dissolved by stirring. This mixture was mixed with the components of (II) described in the following Table 1 previously heated to 80-85° C. and stirred and dissolved, and the mixture was emulsified at 80° C. with a homomixer and cooled under stirring. Then, the mixtures in Examples 1-4 and Comparative Example 1 were adjusted to pH 3.9±0.1, and the mixtures in Examples 5-7 and Comparative Example 2 were adjusted to pH 5.3 with aqueous sodium hydroxide solution as needed. The prepared hair cosmetics were stored at room temperature.
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