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Nisoldipine orally disintegrating tablet and preparation method thereof

A technology of orally disintegrating tablets and nisoldipine, which is applied in the field of nisoldipine orally disintegrating tablets and its preparation, can solve problems affecting drug treatment effects and exacerbating patients' conditions

Inactive Publication Date: 2017-09-01
JIANGXI HERBI SKY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, many patients are often unable to insist on taking medication on time due to the stress of life and work, busy forgetting to take medicine, or inconvenient taking medicine, which greatly affects the therapeutic effect of the medicine, which leads to the aggravation of the patient's condition

Method used

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  • Nisoldipine orally disintegrating tablet and preparation method thereof
  • Nisoldipine orally disintegrating tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Nisoldipine 5g, mannitol 55g, microcrystalline cellulose 27g, low-substituted hydroxypropyl cellulose 3g, croscarmellose sodium 7g, micropowder silica gel 0.2g, tartaric acid 1.5g, aspartame 0.3g, Flavor 0.5g, poloxamer 1.5g, magnesium stearate 0.8g

[0034] Mix the above-mentioned raw materials evenly, press into tablets, and make 1000 pieces, that is to say.

Embodiment 2

[0036] Nisoldipine 5g, mannitol 55g, microcrystalline cellulose 27g, low-substituted hydroxypropyl cellulose 3g, croscarmellose sodium 7g, micropowder silica gel 0.2g, tartaric acid 1.5g, aspartame 0.3g, Flavor 0.5g, poloxamer 1.5g, magnesium stearate 0.8g

[0037] The above-mentioned raw materials are made into 1000 pieces, and the preparation method is as follows:

[0038] Mix nisoldipine, mannitol, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, croscarmellose sodium, micropowder silica gel, tartaric acid, aspartame, essence, poloxamer, and wet It is granulated by law, dried, and the dried granules are evenly mixed with magnesium stearate, and pressed into tablets to obtain the product.

Embodiment 3

[0040] Nisoldipine 5g, mannitol 55g, microcrystalline cellulose 27g, low-substituted hydroxypropyl cellulose 3g, croscarmellose sodium 7g, micropowder silica gel 0.2g, tartaric acid 1.5g, aspartame 0.3g, Flavor 0.5g, poloxamer 1.5g, magnesium stearate 0.8g

[0041] The above-mentioned raw materials are made into 1000 pieces, and the preparation method is as follows:

[0042] Mix nisoldipine, mannitol, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, 5g croscarmellose sodium, micropowder silica gel, tartaric acid, aspartame, and poloxamer, and prepare by wet method Granules, dried, mixed evenly with 2 g of croscarmellose sodium, essence and magnesium stearate, and pressed into tablets to obtain the product.

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Abstract

The invention discloses a nisoldipine orally disintegrating tablet for treatment of high blood pressure and a preparation method thereof. The nisoldipine orally disintegrating tablet contains 2%-10% of nisoldipine, 45%-75% of filler, 10%-30% of a disintegrating agent, 0.1%-3% of a sour agent, 0.1%-10% of a flavoring agent, 0-5% of a flow aid, 0.1%-3% of a lubricant and 0.1-5% of a surfactant. The nisoldipine orally disintegrating tablet provided by the invention has the advantages of strong compressibility, fast disintegration, good drug dissolution and excellent taste.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a nisoldipine orally disintegrating tablet and a preparation method thereof. Background technique [0002] Nisoldipine is a dihydropyridine calcium antagonist, which can prevent the uptake of calcium ions by cardiac muscle and vascular smooth muscle, and has the effect of selectively dilating coronary arteries and peripheral blood vessels, improving myocardial blood supply, reducing peripheral resistance, thereby reducing myocardial oxygen consumption , enhance the tolerance of the myocardium to hypoxia, lower the blood pressure of hypertensive patients, and is mainly used clinically to treat primary mild and moderate hypertension. Nisoldipine is almost completely absorbed after oral administration, reaching the peak blood level 1 hour after oral absorption, and the half-life (t 1 / 2 ) varies greatly among patients, and the single-dose oral half-life (t 1 / 2 ) is 11.4 h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4422A61K47/26A61K47/38A61K47/36A61K47/12A61P9/12
CPCA61K9/0056A61K9/2018A61K9/2059A61K31/4422
Inventor 吴安明吴孔松何杨虎于肖辉黄经球何凤
Owner JIANGXI HERBI SKY CO LTD
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