A kind of high viscoelastic pickering emulsion and its preparation method and application
An elastic and high-viscosity technology, applied in the field of Pickering emulsion, can solve the problems of strong hydrophilicity of pure silica particles, failure to show pH response, unfavorable stability of Pickering emulsion, etc., and achieve good drug release, low production cost, and high viscosity. The effect of high elasticity
Active Publication Date: 2020-01-14
HAINAN UNIV
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However, pure silica particles are highly hydrophilic, which is not conducive to stabilizing Pickering emulsions as a particle emulsifier
In addition, there are no carboxyl or amino groups present on the surface of silica, so it cannot exhibit good pH response
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[0028] The present invention will be further described below in combination with specific embodiments, so as to better understand the present invention.
[0029] 1. Fractal SiO2 2 Synthesis
[0030] First prepare amino-terminated silica (SiO 2 -NH 2 ) particles (Guan et al., 2009). The steps are as follows: add 1.0 g of hydrophilic silica and 10 mL of APTS to 50 mL of ethanol / water (v / v=3:1) at pH=3.6, and then reflux at 80° C. for 12 h. After the mixture was centrifuged, washed three times with ethanol and water respectively, and freeze-dried to obtain amino-terminated silica particles (SiO 2 -NH 2 ). Then prepare aldehyde-terminated silica particles (SiO 2 -CHO) (Shi et al., 2009), the steps are as follows: after dispersing 0.5 g of the above particles in 30 mL (pH=8) phosphate buffer solution, add 50 mL of 25% GA. The reaction was stirred at room temperature for 12h. After the mixture was centrifuged, washed three times with ethanol and water respectively, and free...
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The invention provides multi-layer grafted silicon dioxide nanoparticles, layer-by-layer molecular imprints are used for covalently assembling amino-terminated silicon dioxide and aldehyde-terminated silicon dioxide, and the imprint process is repeated according to needs until the needed silicon dioxide layer number is reached. The invention further provides high-viscoelasticity Pickering emulsion prepared from the nanoparticles. The fractal silicon dioxide is synthesized through the layer-by layer molecular imprint technology and can be used for preparing the high-viscoelasticity Pickering emulsion, the obtained emulsion is high in viscoelasticity, high in stability and good in drug release degree. In addition, the used raw material silicon dioxide particles are low in price and easy to obtain, and the high-viscoelasticity Pickering emulsion is low in production cost and good in biocompatibility and therefore not limited when applied to the fields of food, cosmetics and medicine. The layer-by layer molecular imprint technology is easy to operate and industrialize.
Description
technical field [0001] The invention designs a Pickering emulsion, in particular relates to a highly viscoelastic Pickering emulsion and a preparation method and application thereof. Background technique [0002] Pickering emulsions are mainly stabilized by inorganic rigid particles or polymer soft particles with good surface wettability. These adsorbed particles hinder droplet coalescence by creating strong electrostatic repulsion, large steric hindrance or high interfacial viscosity, resulting in stable emulsions for many years (Pawar et al., 2011; Tambe et al., 1993). A stable Pickering emulsion is widely used in various fields, such as food, cosmetics, coatings, pesticides, and various industrial processes such as emulsion coalescence, metal cutting and cleaning, and synthesis of nanoparticles (Fang et al., 2015; Liu et al. al., 2006; Xiao et al., 2016). However, the opposite demulsification process also has crucial applications in some industrial processes such as ind...
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IPC IPC(8): C01B33/18C01B33/145A61K8/25A61Q19/00A61K31/277A01N25/08A01N25/04A01N53/08A01P7/04
CPCA01N25/04A01N25/08A01N53/00A61K8/25A61K31/277A61Q19/00C01B33/145C01B33/18
Inventor 李嘉诚冯玉红林强余高波陈凯
Owner HAINAN UNIV