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Preparation method of multi-ion co-doped hydroxyapatite powder material

A hydroxyapatite and multi-ion technology, applied in the field of biomedical materials, can solve the problems of few doping types and uncontrollable doping content, and achieve the effects of low production cost, low raw material cost and large output

Active Publication Date: 2017-09-15
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In general, it can be seen from the prior art that there are few researches on multi-ion doped hydroxyapatite materials, and the main problems are: (1) There are few types of doping; (2) The content of doping is not enough (3) The doping source will introduce a large amount of Cl at the same time - , NO 3 - 、Na + Other impurity ions

Method used

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  • Preparation method of multi-ion co-doped hydroxyapatite powder material
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  • Preparation method of multi-ion co-doped hydroxyapatite powder material

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preparation example Construction

[0029] The present invention provides a preparation method of multi-component ion co-doped hydroxyapatite powder material, that is, the present invention provides a 10 (PO 4 ) 6 (OH) 2 Middle Ca position (A position), PO 4 Doping ions are introduced on the position (B position) and OH position (C position), and the doping element at the A position can be selected from metal ions that can replace Ca, including but not limited to K, Na, Mg, Al, Zn, Sr et al. B-site doping can introduce SiO 4 2- and CO 3 2- . C-site doping can introduce F - and CO 3 2- .

[0030] The K, Na, Mg, Al, Zn, Sr, Si, F, C plasma doped multi-ion co-hydroxyapatite powder material provided by the present invention is closer to the composition of human hard tissue, which can obviously promote osteogenesis and It has certain antibacterial properties. The hydroxyapatite nano-powder material doped with trace amounts of multi-ion ions and bone-like components can be used as drug carrier materials,...

Embodiment 1

[0044] Example 1: Preparation of ternary trace Si, Sr, F co-doped HA

[0045] (1) Configuration of the precursor suspension: according to the following chemical formula Ca 10-x Sr x (PO 4 ) 6-y (SiO 4 ) y (OH) 2-y-z f z The stoichiometric ratio of (x=0.001, y=0.002, z=0.01) accurately weighs Ca(H 2 PO 4 ) 2 Formulated as phosphorus source precursor suspension, and Ca(OH) 2 Dubbed calcium source precursor suspension. During the stirring process, add the required trace element source CaF in proportion 2 , SiO 2 , a homogeneous suspension of SrO to Ca(OH) 2 In the calcium source precursor suspension;

[0046] (2) Under stirring conditions, slowly guide the calcium source precursor suspension containing trace elements into the phosphorus source precursor suspension with a glass rod, and stir for 10 minutes;

[0047] (3) Transfer the reaction solution into a 100ml polytetrafluoroethylene container, and set the volume to 90ml. Fix it in the reactor with a stainless s...

Embodiment 2

[0050] Embodiment 2: Preparation of quaternary trace Si, Sr, F, Mg co-doped HA

[0051] (1) Configuration of the precursor suspension: according to the following chemical formula Ca 10-x-a Sr x Mg a (PO 4 ) 6-y (SiO 4 ) y (OH) 2-y-z f z The stoichiometric ratio of (x=0.001, y=0.002, z=0.01) accurately weighs Ca(H 2 PO 4 ) 2 Formulated as phosphorus source precursor suspension, and Ca(OH) 2 Dubbed calcium source precursor suspension. During the stirring process, add the required trace element source CaF in proportion 2 , SiO 2 , a homogeneous suspension of SrO to Ca(OH) 2 In the calcium source precursor suspension, the Mg(H 2 PO 4 ) 2 The solution was added to Ca(H 2 PO 4 ) 2 Formulated into the phosphorus source precursor suspension;

[0052](2) Under stirring conditions, slowly guide the calcium source precursor suspension containing trace elements into the phosphorus source precursor suspension with a glass rod, and stir for 10 minutes;

[0053] (3) Tra...

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Abstract

The invention relates to a preparation method of multi-ion co-doped hydroxyapatite powder material. The composition formula of the multi-ion co-doped hydroxyapatite powder material is [CaaM10-a][(PO4)6-b-c(SiO4)b(CO3)c][(OH)2-e-fFe(CO3)f], wherein M is metal ions capable of substituting Ca for doping, 0<=a<10, 0<=b<=6, 0<=c<6, 0<=e<2, 0<=f<2, and a, b, c, e and f are not all zero. A hydrothermal preparation method of the multi-ion co-coped hydroxyapatite powder material is simple in operation, high in yield, low in costs of raw materials, applicable to scale production and capable of achieving industrial application prospect and value. The prepared multi-ion co-doped hydroxyapatite powder material is high in osteogenic property, obtains certain antibacterial properties and can be widely applied to the fields such as drug carriers, hard tissue repair materials, food and cosmetics.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a method for preparing multiple ion co-doped hydroxyapatite powder materials. Background technique [0002] Hard tissue implant materials are important biomedical materials for the repair and reconstruction of hard tissue injuries. Due to the influence of diseases, aging, frequent traffic accidents and other factors, the demand for hard tissue implant materials is increasing day by day. Hydroxyapatite Ca 10 (PO 4 ) 6 (OH) 2 (HA) is a bioactive material, which is the main component of human hard tissue. After implanted in the human body, it can form a tight bond with the soft and hard tissue of the human body and induce new bone tissue to form on the surface. It has become one of the most widely used hard tissue replacement materials in clinical practice. However, the stability, osseointegration rate, and mechanical strength of pure hydroxyapatite materials ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/455
CPCC01B25/455C01P2002/72C01P2004/03C01P2004/80
Inventor 祝迎春王铭
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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