Preparation and clinical applications of cytokine-rich fat-derived stromal cell composite transplantation material

A technology of cytokines and stromal cells, applied in the field of biomedicine, to achieve the effect of shortening recovery time, good curative effect, and promoting tissue regeneration and repair

Inactive Publication Date: 2017-10-03
黎洪棉
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Its main disadvantage is that it is easy to absorb after transplantation, and the absorption rate accounts for 2

Method used

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  • Preparation and clinical applications of cytokine-rich fat-derived stromal cell composite transplantation material
  • Preparation and clinical applications of cytokine-rich fat-derived stromal cell composite transplantation material
  • Preparation and clinical applications of cytokine-rich fat-derived stromal cell composite transplantation material

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Example Embodiment

[0029] The implementation effect of the present invention will be described in detail below with reference to typical cases.

[0030] Typical case 1

[0031] The patient Wei Moumou, female, 30 years old, went to the doctor because of facial soft tissue depression and uncoordinated contours, and required surgical improvement. On January 29, 2016, local injection of "cytokine-rich adipose-derived stromal cell composite graft material" was performed under local anesthesia, including bilateral temporal injection of 45ml, forehead injection of 30ml, and bilateral buccal injection. Transplant 20ml, chin injection transplant 5ml. After 12 months of follow-up, the facial contour was good, the soft tissue depressions were plump, the graft survived well, the facial skin was significantly improved, and the curative effect was satisfactory.

[0032] Typical case 2

[0033] The patient He Moumou, female, 26 years old, went to the doctor due to the incongruity of soft tissue depression i...

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Abstract

The invention discloses the preparation and clinical application of a fat-derived stromal cell composite graft material rich in cytokines. The preparation method is through 1) the acquisition and purification of fat granules; 2) the acquisition of nano-fat stromal cells; 3) the biological characteristics and multi-directional differentiation identification of nano-fat-derived stem cells (NFSCs); 4) fibrin glue rich in cytokines The preparation of transplant materials in four steps is used for the clinical repair and correction of sunken deformities of the face, chest and other body surface soft tissues. The invention is based on the new technology of stromal vascular components to promote trauma or wound repair, reduce scar hyperplasia, promote tissue regeneration repair and organ reconstruction, shorten the recovery time of patients, improve the quality of rehabilitation, and achieve good curative effect. It is a clinically assisted autologous fat Tissue transplantation provides experimental basis and theoretical support for the repair of soft tissue or organ defects, burn wounds, refractory wounds, and breast reconstruction after breast cancer surgery.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the preparation and clinical application of a fat-derived stromal cell composite graft material rich in cytokines. Background technique [0002] Depression and deformity of body surface tissues and organs due to trauma, infection, tumor resection or congenital defects, etc., not only affect the appearance, but also affect the patient's mental health and social communication activities to varying degrees. Autologous fat grafting is currently one of the main methods for the treatment of soft tissue depressions or asymmetrical contours. Its main disadvantage is that it is easy to absorb after transplantation, and the absorption rate accounts for 20% to 90%. Most of them need to receive repeated injections to achieve a satisfactory effect. research hotspots. [0003] Adipocytes lack effective blood supply in the early stage of transplantation. Before the blood suppl...

Claims

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Application Information

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IPC IPC(8): A61L27/38A61L27/54C12N5/077C12N5/0775C07K14/75
CPCA61L27/3834A61L27/54A61L2300/252A61L2300/414A61L2400/06A61L2430/04C07K14/75C12N5/0653C12N5/0667
Inventor 黎洪棉梁至洁朱丹丹吴芳晓何宁
Owner 黎洪棉
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