Fast preparation method of nanometer particle gel medicine carrying system

A nanoparticle and drug-loading system technology, applied in the medical field, can solve problems such as complicated preparation methods and long gelation time, and achieve the effects of high drug encapsulation rate, low water loss rate, and shortened gel formation time

Active Publication Date: 2017-10-10
QUFU NORMAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problems of complex preparation methods and long gelation time in the process of preparing nanoparticle gel

Method used

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  • Fast preparation method of nanometer particle gel medicine carrying system
  • Fast preparation method of nanometer particle gel medicine carrying system
  • Fast preparation method of nanometer particle gel medicine carrying system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Effect of 0.002g / mL hyaluronic acid on the formation time of nanoparticle gel drug-loaded system

[0030] A method for preparing a nanoparticle gel drug-carrying system using hyaluronic acid, the steps are:

[0031] 1) Add nanoparticles (nanosilver, 10-100nm) into sterilized deionized water, sonicate for 20 minutes, mix well, and prepare a 0.15mg / mL nanoparticle solution;

[0032] 2) Add poly-γ-glutamic acid to sterilized deionized water, stir to dissolve, and prepare a transparent poly-γ-glutamic acid solution with a concentration of 0.07g / mL, and then add the nanoparticle solution prepared in step 1) to it, Make the mass ratio of nanoparticles and poly-γ-glutamic acid in the solution be 0.1: 46.7, stir evenly, obtain the poly-γ-glutamic acid solution of nanoparticles;

[0033] 3) Add hyaluronic acid (molecular weight 2500-3000KD) into the poly-γ-glutamic acid solution of nanoparticles prepared in step 2), the concentration of hyaluronic acid is 0.002g / mL, s...

Embodiment 2

[0039] Example 2 Effect of 0.004g / mL hyaluronic acid on the formation time of nanoparticle gel drug-loaded system

[0040] A method for preparing a nanoparticle gel drug-carrying system using hyaluronic acid, the steps are:

[0041] 1) Add nanoparticles (nanocopper, 10-100nm) into sterilized deionized water, sonicate for 20 minutes, mix well, and prepare 0.15mg / mL nanoparticle solution;

[0042] 2) Add poly-γ-glutamic acid to sterilized deionized water, stir to dissolve, and prepare a transparent poly-γ-glutamic acid solution with a concentration of 0.07g / mL, and then add the nanoparticle solution prepared in step 1) to it, Make the mass ratio of nanoparticles and poly-γ-glutamic acid in the solution be 0.1: 46.7, stir evenly, obtain the poly-γ-glutamic acid solution of nanoparticles;

[0043]3) Add hyaluronic acid (molecular weight 2500-3000KD) into the poly-γ-glutamic acid solution of nanoparticles prepared in step 2), the concentration of hyaluronic acid is 0.004 g / mL, sti...

Embodiment 3

[0049] Example 3 Effect of 0.006g / mL hyaluronic acid on the formation time of nanoparticle gel drug-loaded system

[0050] A method for preparing a nanoparticle gel drug-carrying system using hyaluronic acid, the steps are:

[0051] 1) Add nanoparticles (nanosilver, 10-100nm) into sterilized deionized water, sonicate for 20 minutes, mix well, and prepare a 0.15mg / mL nanoparticle solution;

[0052] 2) Add poly-γ-glutamic acid to sterilized deionized water, stir to dissolve, prepare a 0.07g / mL transparent solution, and then add the nanoparticle solution prepared in step 1) to the transparent solution to make the solution The mass ratio of nanoparticles to poly-γ-glutamic acid is 0.1:46.7, and the mixture is evenly stirred to obtain a solution of poly-γ-glutamic acid rich in nanoparticles;

[0053] 3) Add hyaluronic acid (molecular weight 2500-3000KD) into the poly-γ-glutamic acid solution of nanoparticles prepared in step 2), stir evenly, the concentration of hyaluronic acid is...

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Abstract

The invention discloses a fast preparation method of a nanometer particle gel medicine carrying system. Poly gamma-glutamic acid, Chitosan oligosaccharide, hyaluronic acid, nanometer particles, rhamnolipid and crosslinking agents EDC/NHS are used for preparing gel; under the catalytic effect of crosslinking agents, intermolecular crosslinking reaction is performed. According to the method provided by the invention, the hyaluronic acid is used as a catalyst to be matched with the rhamnolipid and the crosslinking agents EDC/NHS; the gel formation time can be effectively reduced, so that the gel has more excellent gel performance; high bioactivity performance and good biocompatibility are realized; the swelling properties are good; the raw materials are cheap; the obtaining is easy; the production process is simple.

Description

technical field [0001] The invention belongs to the field of medical technology, and relates to a rapid preparation method of a nanoparticle gel drug-carrying system. Background technique [0002] In recent years, with the improvement of scientific and technological level, people have gradually increased the research on the drug loading system, and then expanded the application range of the drug itself. The research on the drug loading system, especially the research on the nanogel drug loading system, has become research hotspot. [0003] At present, most of the preparation methods of nanoparticle hydrogels are to prepare high molecular polymers into hydrogel dressings by means of chemical cross-linking agents or physical radiation. There are great differences in various properties such as capacity, and there are many problems such as complicated preparation methods, long gelation time, and high cost. Contents of the invention [0004] In order to solve the problems of ...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/36A61K47/02A61K47/34A61K47/26A61K31/337A61K33/24A61P35/00A61K8/73A61K8/88A61K8/60A61K8/19A61Q19/00A61L26/00
CPCA61K8/19A61K8/60A61K8/735A61K8/88A61K9/06A61K31/337A61K33/24A61K47/02A61K47/26A61K47/34A61K47/36A61L26/0004A61L26/0019A61L26/0023A61L26/008A61L26/009A61Q19/00C08L5/08C08L77/04
Inventor 杨革梁鑫鑫车程川刘金锋巩志金李媛
Owner QUFU NORMAL UNIV
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