Method for preparing thermosensitive alternate laminar drug release composite material

Abstract

The invention discloses a method for preparing a thermosensitive alternate laminar drug release composite material. The method is mainly characterized by preparing the thermosensitive alternate laminar drug release composite material of which a polymer-based drug loading layer and a polymer-based temperature response layer are alternately and orderly arranged through fusion co-extrusion, regulating morphological structures of the polymer-based drug loading layer and the polymer-based temperature response layer through a shear tensile action under the action of a laminar overlay force field in an extrusion process, improving drug diffusion and temperature response release channels, enabling the obtained thermosensitive alternate laminar drug release composite material to have a reasonable initial drug release amount and a temperature response drug release property, realizing controllable, flexible and effective release of a drug, and meeting different drug release requirements. According to the thermosensitive alternate laminar drug release composite material prepared by the invention, the morphology can be structured, and the property can be designed; the thermosensitive alternate laminar drug release composite material can be biodegraded, is safe and non-toxic, is good in mechanical property, can be continuously produced, is flexible and controllable in drug release behavior, and has remarkable research value and remarkable application prospect in the field of drug response release.

Description

technical field [0001] The present invention relates to a preparation method of a temperature-sensitive alternating layered drug release composite material, and more specifically relates to a kind of structural form can be configured, performance can be designed, biodegradable, safe and non-toxic, excellent mechanical properties, can be The invention relates to a method for continuous production and flexible and controllable drug release behavior of temperature-sensitive alternating layered drug release composite materials, belonging to the technical field of functional composite materials. Background technique [0002] Environmentally responsive drug sustained-release materials refer to materials that can respond to external environmental stimuli to achieve controlled release of the loaded drug. Compared with traditional drug delivery systems, they can change in shape or chemical structure with the stimulation of physical factors (electric field, magnetic field, temperature...

AI Technical Summary

Problems solved by technology

[0014] In view of the shortcomings of the traditional solution method for preparing temperature-sensitive layered drug release materials, such as harsh preparation conditions, poor biocompatibility of the selected monomers, and difficult control of the single-layer structure and interlayer compounding of the material, the purpose of the present invention is to propose a A method of temperature-sensitive alternating layered drug release composite material with customizable structure, designable performance, biodegradable, safe and non-toxic, excellent mechanical properties, continuous production, and flexible and controllable drug release behavior

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