Method for preparing thermosensitive alternate laminar drug release composite material

A composite material and alternating layer technology, which is applied in the field of preparation of temperature-sensitive alternating layered drug release composite materials, can solve the problems of poor biocompatibility of monomers, difficult control of single-layer structure and interlayer compounding, and harsh preparation conditions , to achieve good biocompatibility, easy hot-melt processing, and weaken the effect of burst release

Inactive Publication Date: 2017-10-20
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0014] In view of the shortcomings of the traditional solution method for preparing temperature-sensitive layered drug release materials, such as harsh preparation conditions, poor biocompatibility of the selected monomers, and difficult control of the single-layer structure and interlayer compounding of the material, the pur

Method used

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  • Method for preparing thermosensitive alternate laminar drug release composite material
  • Method for preparing thermosensitive alternate laminar drug release composite material

Examples

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Embodiment 1

[0048] A polycaprolactone (drug-loaded layer matrix)-polyethylene glycol (drug-loaded layer dispersed phase)-diclofenac sodium (drug) / polycaprolactone (temperature-responsive layer matrix)-glycerol trilaurate (temperature-responsive Layer temperature response functional phase) The raw materials of the temperature-sensitive alternating layered drug release composite material include the following components and contents in parts by weight:

[0049] Polymer-based drug-loaded layer component distribution ratio parts by weight

[0050] Polycaprolactone (for the drug-loaded layer matrix) 90

[0051] Polyethylene glycol (for the dispersed phase of the drug loading layer) 10

[0052] Diclofenac sodium (as a drug) 5

[0053] Polymer-based temperature-responsive layer composition ratio Parts by weight

[0054] Polycaprolactone (as the temperature response layer matrix) 90

[0055] Glyceryl trilaurate (for the temperature response layer temperature response functional phase) 10

[...

Embodiment 2

[0065] A polycaprolactone (drug-loaded layer matrix)-polyethylene glycol (drug-loaded layer dispersed phase)-diclofenac sodium (drug) / polycaprolactone (temperature-responsive layer matrix)-glycerol trilaurate (temperature-responsive Layer temperature response functional phase) The raw materials of the temperature-sensitive alternating layered drug release composite material include the following components and contents in parts by weight:

[0066] Drug-loaded layer component distribution ratio parts by weight

[0067] Polycaprolactone (as the drug-loaded layer matrix) 80

[0068] Polyethylene glycol (for the dispersed phase of drug loading layer) 20

[0069] Diclofenac sodium (as a drug) 10

[0070] Temperature-responsive layer group distribution ratio parts by weight

[0071] Polycaprolactone (as the temperature response layer matrix) 85

[0072] Glyceryl trilaurate (for the temperature response layer temperature response functional phase) 15

[0073] Note: The drug-load...

Embodiment 3

[0082] A polybutylene succinate (drug-loaded layer matrix)-polyethylene glycol (dispersed phase of the drug-loaded layer)-metoprolol tartrate (drug) / polybutylene succinate (temperature-responsive layer Matrix)-glycerol tristearate (temperature-responsive layer temperature-responsive functional phase) The raw materials of the temperature-sensitive alternating layered drug release composite material include the following components and contents in parts by weight:

[0083] Drug-loaded layer component distribution ratio parts by weight

[0084] Polybutylene succinate (as the drug loading layer matrix) 80

[0085] Polyethylene glycol (for the dispersed phase of drug loading layer) 20

[0086] Metoprolol tartrate (as drug) 10

[0087] Temperature-responsive layer group distribution ratio parts by weight

[0088] Polybutylene succinate (substrate for temperature responsive layer) 85

[0089] Glycerol tristearate (for the temperature response layer temperature response functional...

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Abstract

The invention discloses a method for preparing a thermosensitive alternate laminar drug release composite material. The method is mainly characterized by preparing the thermosensitive alternate laminar drug release composite material of which a polymer-based drug loading layer and a polymer-based temperature response layer are alternately and orderly arranged through fusion co-extrusion, regulating morphological structures of the polymer-based drug loading layer and the polymer-based temperature response layer through a shear tensile action under the action of a laminar overlay force field in an extrusion process, improving drug diffusion and temperature response release channels, enabling the obtained thermosensitive alternate laminar drug release composite material to have a reasonable initial drug release amount and a temperature response drug release property, realizing controllable, flexible and effective release of a drug, and meeting different drug release requirements. According to the thermosensitive alternate laminar drug release composite material prepared by the invention, the morphology can be structured, and the property can be designed; the thermosensitive alternate laminar drug release composite material can be biodegraded, is safe and non-toxic, is good in mechanical property, can be continuously produced, is flexible and controllable in drug release behavior, and has remarkable research value and remarkable application prospect in the field of drug response release.

Description

technical field [0001] The present invention relates to a preparation method of a temperature-sensitive alternating layered drug release composite material, and more specifically relates to a kind of structural form can be configured, performance can be designed, biodegradable, safe and non-toxic, excellent mechanical properties, can be The invention relates to a method for continuous production and flexible and controllable drug release behavior of temperature-sensitive alternating layered drug release composite materials, belonging to the technical field of functional composite materials. Background technique [0002] Environmentally responsive drug sustained-release materials refer to materials that can respond to external environmental stimuli to achieve controlled release of the loaded drug. Compared with traditional drug delivery systems, they can change in shape or chemical structure with the stimulation of physical factors (electric field, magnetic field, temperature...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/34A61K47/38A61K47/14A61K47/12A61K47/10A61K47/32A61K47/36A61K31/196A61K31/138A61K31/4422A61K31/545
CPCA61K9/0002A61K31/138A61K31/196A61K31/4422A61K31/545A61K47/10A61K47/12A61K47/14A61K47/32A61K47/34A61K47/36A61K47/38
Inventor 郭少云潘瑞陈蓉周虹汛
Owner SICHUAN UNIV
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