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Technology for removing proteins and heparin-like materials in sodium heparin crude extract liquid

A technology of heparin sodium and protein, applied in the field of protein recovery, can solve the problems of incomplete removal of pollutants and long process cycle, and achieve the effects of fast flocculation and sedimentation, small dosage, and strong bridging adsorption performance.

Inactive Publication Date: 2017-10-20
盐城盛大肠衣食品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the treatment process has a long cycle and the removal of pollutants is not complete

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Extract 6000L of waste water of heparin sodium, temperature 45°C, pH 8.5, salt content 4.5%, add polyaluminum chloride solution 30KG (concentration 50%), stir for 10 minutes, after stirring evenly, add polyacrylamide solution 20KG (concentration 10%), continue to stir for 10 minutes, turn off the stirring, let stand for 10 minutes, the protein precipitates to the bottom, the supernatant is clarified, sucks off the supernatant solution, collects the bottom protein, dries, weighs, and the weight is 78KG.COD removal rate is 96 %, the protein recovery rate was 98%.

Embodiment 2

[0021] Extract 8000L of waste water of heparin sodium, temperature 44°C, pH 8.0, salt content 4.4%, add polyaluminum chloride solution 40KG (concentration 50%), stir for 10 minutes, after stirring evenly, add polyacrylamide solution 25KG (concentration 10%) %), continue to stir for 10 minutes, turn off the stirring, let stand for 10 minutes, the protein precipitates to the bottom, the supernatant is clarified, and the supernatant solution is sucked out, the bottom protein is collected, dried, weighed, and the weight is 102KG.COD removal rate is 97% , The protein recovery rate was 99%.

Embodiment 3

[0023] Extract 4000L of waste water of heparin sodium, temperature 46°C, pH 8.3, salt content 4.6%, add polyaluminum chloride solution 20KG (concentration 50%), stir for 10 minutes, after stirring evenly, add polyacrylamide solution 13KG (concentration 10%) %), continue to stir for 10 minutes, turn off the stirring, let stand for 10 minutes, the protein precipitates to the bottom, the supernatant is clarified, and the supernatant solution is sucked out, the bottom protein is collected, dried, weighed, and the weight is 50KG.COD removal rate is 95% , The protein recovery rate was 98%.

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Abstract

The invention particularly relates to a technology for removing proteins and heparin-like materials in sodium heparin crude extract liquid. The technology which is a method for recycling the proteins in sodium heparin extraction waste liquid includes adding aluminum salt solution into the sodium heparin extraction waste liquid and stirring the aluminum salt solution and the sodium heparin extraction waste liquid to obtain first solution; adding flocculating agent solution into the uniformly stirred first solution and stirring the flocculating agent solution and the first solution to obtain second solution; allowing the second solution to stand still when a large quantity of flocculated precipitates appear in the second solution; sucking off supernatant and collecting the precipitates; drying the precipitates to obtain the proteins. The technology has the advantages that polyaluminum chloride is high in bridging and adsorption performance, and physical and chemical procedures such as coagulation, adsorption and precipitation can be carried out in an accompany manner in hydrolysis procedures; the polyaluminum chloride structurally comprises morphology-changeable poly-carboxyl complex compounds, is high in flocculation and precipitation speed and wide in pH (potential of hydrogen) value application range and is free of corrosion for pipeline equipment; polyacrylamide with a high molecular weight can be 'bridged' between adsorbed particles to generate floccules and is favorable for settling the particles, low in usage and high in efficiency, and after-treatment can be facilitated.

Description

technical field [0001] The invention relates to a method for recovering protein from industrial waste water, in particular to a technology for removing protein and heparin-like substances in heparin sodium crude extract. Background technique [0002] Heparin is a mucopolysaccharide widely present in mammalian tissues. Heparin sodium is the sodium salt of heparin, which has anticoagulant, antithrombotic and blood lipid regulating effects, and also has anti-inflammatory, anti-allergic, anti-viral, anti-cancer and other functions. It is widely used in surgery and treatment of cerebral thrombosis and myocardial infarction. As a natural anticoagulant substance, heparin sodium has been valued by countries all over the world. It is also one of the main export drugs in my country. Crude heparin sodium is a traditional export product of our country and occupies an important position in the world. [0003] At present, heparin sodium is mainly extracted from the small intestinal muco...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C02F1/52C02F1/56C07K1/30
CPCC02F1/5236C02F1/56C02F2301/08C07K1/30
Inventor 菜同文菜俊伟菜俊林
Owner 盐城盛大肠衣食品有限公司
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