Method and equipment for treating opium poppy

Abstract

The invention discloses a method for treating opium poppy extract, which comprises the following steps: a, adding a polar solvent into the opium poppy extract, and reacting to obtain a first treating fluid; b, adding a filter aid into the first treating fluid, and filtering to obtain a first extract liquid; c, separating the first extract liquid through a chromatographic column which is filled with spherical silica gel of a bonded stationary phase and a mixture of alcohol and inorganic acid serving as a mobile phase; and d, eluting to obtain a fraction containing alkaloid. Compared with the prior art, the method has the advantages of separating morphine, codeine, thebaine and other monomer alkaloids, and the alkaloid monomer has high purity and large yield.

Description

technical field [0001] The invention relates to a method for separating and purifying monomer drugs morphine, codeine and thebaine from poppy extract by using industrial preparation chromatography and traditional crystallization method. Background technique [0002] Pain is a protective response of the body to noxious stimuli in the internal and external environment, which includes both real or potential tissue damage and mental damage. There are hundreds of different types of drugs used to treat pain, and their mechanisms vary. It has become a trend to search for highly effective, low-toxic, and non-dependent analgesics from natural medicines. All kinds of active monomer substances contained in poppy extract are the most widely used and most demanded natural alkaloid analgesic drugs in the world. [0003] Unripe poppy fruit contains a large amount of milky white liquid, which can form a brown or brown-black paste after drying. Poppy extract is a crude alkaloid obtained b...

AI Technical Summary

Problems solved by technology

[0006] This method uses the traditional resin adsorption method. Due to the poor adsorption selectivity of the resin method, only the morphine component with the highest content in the poppy extract can be obtained, and other effective components such as codeine and thebaine with high medicinal value It cannot be recovered, and the content of the obtained crude morphine is low, generally only reaching about 80%, which cannot reach the medicinal standard, and complex purification treatment is still required in the later stage, resulting in low yields of these active alkaloids

At the same time, resin adsorption has the disadvantages of small adsorption amount and long adsorption time, which lead to a long production cycle of this method, large space occupation of required equipment, and high production cost.

In addition to the above problems, the resin method will generate a large amount of industrial wastewater during the production process. These wastewater need to be treated professionally, which virtually increases the cost of production and is not suitable for large-scale industrial production.

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