Ferric iron porphyrin and derivative of ferric iron porphyrin-oligopeptide compound and application of ferric iron porphyrin and derivative of ferric iron porphyrin-oligopeptide compound

A technology of ferric iron and derivatives, which is applied in the field of medicine to achieve the effect of slowing down the paralysis trend of nematodes and prolonging lifespan

Inactive Publication Date: 2017-11-03
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This type of peroxide mimetic enzyme has a strong ability to penetrate the cell membrane and scavenge free radicals in the cell, so it has good antioxidant activity, and its application in the preparation of drugs for the treatment of Alzheimer's disease has not been found in the literature after searching. to report

Method used

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  • Ferric iron porphyrin and derivative of ferric iron porphyrin-oligopeptide compound and application of ferric iron porphyrin and derivative of ferric iron porphyrin-oligopeptide compound
  • Ferric iron porphyrin and derivative of ferric iron porphyrin-oligopeptide compound and application of ferric iron porphyrin and derivative of ferric iron porphyrin-oligopeptide compound
  • Ferric iron porphyrin and derivative of ferric iron porphyrin-oligopeptide compound and application of ferric iron porphyrin and derivative of ferric iron porphyrin-oligopeptide compound

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Experimental program
Comparison scheme
Effect test

Embodiment 1D

[0027] The solid-phase synthesis of embodiment 1Dh-β-Ala-His-Glu

[0028] (1) Resin swelling: weigh 0.1mmol Rink-NH 2 Resin, add dichloromethane reagent to fully infiltrate the resin, swell for 1 hour, remove the dichloromethane by suction filtration, and wash the resin 6 times with dimethylformamide (DMF).

[0029] (2) Deprotection: to step (1) processed Rink-NH 2 Add DEP (DMF containing 20% ​​piperidine) solution to the resin, shake at room temperature for 15-30min, filter with suction, wash the resin 6 times with DMF, and use the color developer (A: 5% ninhydrin ethanol solution B: 80% Phenol ethanol solution) to detect the deprotection of the amino group, when the resin particles all turn blue-purple, the deprotection is complete.

[0030] (3) Connecting amino acids: Fmoc-Glu(otBu)-OH, PyBOP (benzotriazol-1-yl-oxytripyrrolidinylphosphonium hexafluorophosphate), HOBT (1-Hydroxybenzotriazole), NMM (N- methylmorpholine) and Rink-NH 2 The resin is added to the reactor sequ...

Embodiment 2

[0037] Example 2 Effect of compound Dh-β-Ala-His-Thr-Val-Glu-Lys on Caenorhabditis elegans

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Abstract

The invention discloses a ferric iron porphyrin and a derivative of the ferric iron porphyrin, an oligopeptide compound, and an application of the ferric iron porphyrin and the derivative of the ferric iron porphyrin, the oligopeptide compound. The ferric iron porphyrin and the derivative of the ferric iron porphyrin, the oligopeptide compound, comprise deuterohemin and oligopeptide, wherein a carboxyl on the deuterohemin and an amino on an oligopeptide peptide chain are connected, so that the oligopeptide is a tripeptide. The ferric iron porphyrin and the derivative of the ferric iron porphyrin, the oligopeptide compound, prolong the service life of a nematode CL4176 of an alzheimer's disease model and slow down the tendency of paralysis of the nematode, therefore, a new direction for the research and development of medicines is provided for treating the alzheimer's disease.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a ferric porphyrin and its derivative-short peptide compound and the application of the ferric porphyrin and its derivative-short peptide compound. Background technique [0002] Alzheimer's disease (Alzheimer's disease, AD), commonly known as senile dementia, is a severe senile dementia, manifested as severe cognitive dysfunction, loss of self-care ability and mental behavioral disturbance. According to statistics, with the acceleration of population aging, the prevalence of AD over the age of 65 is about 1%-5%, while the prevalence of AD over the age of 85 is as high as 20%-40%. The high fatality rate ranks AD as the fifth leading cause of death among conditions in the elderly population. The pathogenesis of AD is complex, among which the "Aβ protein cascade hypothesis" is the most studied. Aβ exerts neurotoxicity by inducing apoptosis, triggering inflammatory cascade reaction, generat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K5/083C07K7/06A61K38/06A61K38/08A61P25/28
CPCA61K38/00C07K5/0806C07K7/06
Inventor 王丽萍李惟关树文徐佳张越
Owner JILIN UNIV
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