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Rutaecarpine alkali gold salt as well as synthesis method and application thereof

A technology of evodiamine and its synthesis method, which is applied in the field of medicine, can solve the problems of retention and no research on evodiamine, and achieves the effects of low cost, easy control of reaction conditions, and simple synthesis method

Inactive Publication Date: 2017-11-10
YULIN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the previous studies were still at the stage of small organic molecules, and the metal salts or complexes of evodiamine have not yet been studied.

Method used

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  • Rutaecarpine alkali gold salt as well as synthesis method and application thereof
  • Rutaecarpine alkali gold salt as well as synthesis method and application thereof
  • Rutaecarpine alkali gold salt as well as synthesis method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Weigh evodiamine (0.03g, 0.1mmol), HAuCl 4 4H 2 O (0.06g, 0.15mmol), respectively dissolved in 5ml of chloroform and 5ml of methanol, mixed and placed in a 50ml round bottom flask, heated in a water bath at 55°C for 3 hours to make it react completely, filtered, and at room temperature Volatilize to obtain light red massive crystals, wash with petroleum ether and chloroform, and dry to obtain the subalkaline gold salt of Evodia rutaecarpa, with a yield of 87.1%.

[0025] Product detection: carry out infrared spectrum and X-ray single crystal diffraction analysis respectively to the red solid product obtained above, such as Figure 1~2 shown, where figure 1 It is the infrared spectrogram of evodia rutaecarpine gold salt of the present invention; figure 2 It is the X-ray single crystal diffraction structure diagram of the gold salt of evodia rutaecarpa in the present invention.

[0026] figure 1 Specific spectral features are as follows:

[0027] IR spectrum: 3457,...

Embodiment 2

[0051]Weigh evodiamine (3g, 10mmol), HAuCl 4 4H 2 O (6g, 15mmol), respectively dissolved in 250ml of chloroform and 250ml of methanol, mixed and placed in a 1000ml round bottom flask, heated in a water bath at 55°C for 3 hours to make it react completely, filtered, and volatilized at room temperature to obtain The light red massive crystals were washed with petroleum ether and chloroform, and dried to obtain the gold salt of evodia rutaecarpa, with a yield of 83.5%.

[0052] The product detection method is the same as in Example 1.

Embodiment 3

[0054] Weigh evodiamine (3g, 10mmol), HAuCl 4 4H 2 O (6g, 15mmol), respectively dissolved in 250ml of chloroform and 250ml of methanol, mixed and placed in a 1000ml round bottom flask, heated in a water bath at 65°C for 5 hours to make it react completely, filtered, and volatilized at room temperature to obtain The light red massive crystals were washed with petroleum ether and chloroform, and dried to obtain the gold salt of evodia rutaecarpa, with a yield of 85.3%.

[0055] The product detection method is the same as in Example 1.

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Abstract

The invention discloses a rutaecarpine alkali gold salt as well as a synthesis method and an application thereof, belongs to the technical field of medicines and aims to provide the rutaecarpine alkali gold salt, the synthesis method thereof and the novel application of the rutaecarpine alkali gold salt in the antitumor field. The structural formula of the rutaecarpine alkali gold salt is as shown in the description. The rutaecarpine alkali gold salt can be used for preparing an antitumor medicine.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a gold salt of evodia rutacarpa and its synthesis method and application. Background technique [0002] The ligand selection of the present invention is derived from Rutaecarpine, an active ingredient of the traditional Chinese medicine Evodia rutaecarpine alkaloids. Since the successful clinical use of cisplatin anti-tumor metal drugs, the research on its related platinum complexes and other metal complexes, such as gold complexes, has attracted more and more attention. Evodiamine belongs to the classic mother nucleus structure of indolequinazoline alkaloids. This functional structure can easily chelate with metal ions to form complexes or exist in the form of alkaloid salts. The double-effect synergistic effect of ions, so the combination of gold ions and active rutaxine to form metal complexes or gold ion salt compounds is expected to have anti-tumor activity similar to cisp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D471/14A61P35/00
CPCC07B2200/13C07D471/14
Inventor 谭明雄黄国保申文英
Owner YULIN NORMAL UNIVERSITY
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