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Traditional Chinese medicine oral microemulsion preparation method and traditional Chinese medicine oral microemulsion thereof

A technology of microemulsion and traditional Chinese medicine, which is applied in the direction of medical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve problems such as instability of traditional Chinese medicine oral emulsions

Active Publication Date: 2017-11-17
江西广恩和药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the unstable problem of traditional Chinese medicine oral emulsion, the invention provides a preparation method of traditional Chinese medicine oral microemulsion and traditional Chinese medicine oral microemulsion. The present invention adopts a three-step method in the process of preparing the microemulsion, that is, first forms oil-in-water colostrum |, then add emulsifier to form colostrum II, and finally add aqueous solution extract to form traditional Chinese medicine microemulsion. The traditional Chinese medicine oral microemulsion prepared in this way is stable in properties, small in particle size, and will not merge and break, demulsify and delaminate, and flocculate. Aggregation, rancidity and other issues

Method used

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  • Traditional Chinese medicine oral microemulsion preparation method and traditional Chinese medicine oral microemulsion thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0039] The preparation method of Xiangsha nourishing stomach oral microemulsion comprises the following steps:

[0040] S1: Take 70g of Muxiang, 70g of Amomum, 100g of Atractylodes Rhizome, 100g of Tangerine Peel, 100g of Poria, 100g of Pinellia, 70g of Cyperus cyperus, 70g of fried Citrus aurantium, 70g of shelled cardamom, 70g of Magnolia officinalis made from ginger, 70g of patchouli and Extract the volatile oil from 30g of licorice, collect the volatile oil for later use; decoct the remaining medicinal residues with water, filter, concentrate the filtrate to a clear paste with a relative density of 1.2 at 75°C, cool to a temperature of 40°C, add ethanol with an alcohol content of 80%, and let it stand for 12 hours , take the supernatant to recover ethanol to a clear paste with a relative density of 1.2 at 75°C, add deionized water to the remaining liquid, adjust the pH to 4, let it stand for 12 hours, and filter to obtain a clear aqueous extract;

[0041] S2: Take 12.8 g o...

Embodiment 2

[0045] The preparation method of Xiangsha nourishing stomach oral microemulsion comprises the following steps:

[0046] S1: Take 70g of Muxiang, 70g of Amomum, 100g of Atractylodes Rhizome, 100g of Tangerine Peel, 100g of Poria, 100g of Pinellia, 70g of Cyperus cyperus, 70g of fried Citrus aurantium, 70g of shelled cardamom, 70g of Magnolia officinalis made from ginger, 70g of patchouli and Extract the volatile oil from 30g of licorice, collect the volatile oil for later use; decoct the remaining medicinal residues with water, filter, concentrate the filtrate to a clear paste with a relative density of 1.2 at 75°C, cool to a temperature of 40°C, add ethanol with an alcohol content of 80%, and let it stand for 12 hours , take the supernatant to recover ethanol to a clear paste with a relative density of 1.2 at 75°C, add deionized water to the remaining liquid, adjust the pH to 4, let it stand for 12 hours, and filter to obtain a clear aqueous extract;

[0047] S2: Take 12.8 g o...

Embodiment 3

[0051] The difference between Example 3 and Example 1 is that in step S4, the aqueous extract is mixed and dissolved with sodium saccharin and sodium benzoate, and then added to the colostrum II obtained in step S3. Wherein the add-on of sodium saccharin is 1.6g, and the add-on of sodium benzoate is 4.8g.

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Abstract

The invention relates to a traditional Chinese medicine oral microemulsion preparation method. The preparation method comprises the following steps: S1) extracting an oil-soluble component and a water-soluble component in the traditional Chinese medicine raw materials to obtain grease and an aqueous solution extract product; S2) adding a solubiliser and deionized water in grease, employing a homogenizer for shearing and stirring for 5-10 min at high speed under normal pressure to prepare a primary emulsion I; S3) adding an emulsifier in the primary emulsion I, employing the homogenizer for shearing and stirring for 5-10 min at the high speed under normal pressure to prepare a primary emulsion II; and S4) adding the aqueous solution extract product in the S1) in the primary emulsion II, adding the deionized water, employing the homogenizer for shearing and stirring for 5-10 min at the high speed under normal pressure, performing low speed pressurization and stirring the material for 5-10 min, and performing loading and disinfection to obtain the traditional Chinese medicine oral microemulsion. The traditional Chinese medicine oral microemulsion has stable property, and cannot generate problems of merging and demulsification, creaming and layering, flocculation and acetification.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and relates to a preparation method of a traditional Chinese medicine oral preparation and a traditional Chinese medicine oral preparation, in particular to a preparation method of a traditional Chinese medicine oral microemulsion and the traditional Chinese medicine oral microemulsion. Background technique [0002] The effective components of traditional Chinese medicine can be divided into water-soluble components and oil-soluble components. The water-soluble components of traditional Chinese medicine can be extracted with water, and the oil-soluble components can be extracted by reflux extraction or pressing method or extracted with a solvent with low polarity. However, the oil-soluble components and The water-soluble components cannot be miscible with each other, resulting in oil-water separation, which does not meet the requirement of uniform preparation. [0003] Mic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61K9/107A61K47/26A61K47/36A61P1/00
CPCA61K9/0053A61K9/1075A61K36/076A61K36/284A61K36/285A61K36/484A61K36/532A61K36/575A61K36/752A61K36/8888A61K36/8905A61K36/9064A61K47/26A61K47/36A61K2236/51A61K2236/53A61K2300/00
Inventor 曾爱忠
Owner 江西广恩和药业股份有限公司