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Raphanin-containing gastric retention composition and preparation method thereof

A technology for composition and gastric retention, which is applied in the direction of drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of inability to guarantee the stability of the active ingredient radishin and poor drug efficacy, and achieve prolonged direct action Time and drug concentration, improve drug efficacy, ensure stable effect

Inactive Publication Date: 2017-11-24
SHENZHEN ELDERLY MEDICAL RES INST +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the above-mentioned deficiencies of the prior art, provide a gastric retention composition and its preparation method, to solve the problem that the stability of the active ingredient radishin cannot be ensured during the storage period of the existing radishene-containing products, which leads to the drug effect. poor technical problem

Method used

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  • Raphanin-containing gastric retention composition and preparation method thereof
  • Raphanin-containing gastric retention composition and preparation method thereof
  • Raphanin-containing gastric retention composition and preparation method thereof

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preparation example Construction

[0048] In another aspect, on the basis of the above-mentioned embodiments of the present invention, the embodiments of the present invention provide a preparation method of the above-mentioned gastric retention composition. Described preparation method comprises the steps:

[0049] Step S01: according to the components contained in the gastric retention composition described above;

[0050] Step S02: performing mixing treatment on the weighed rapaidulin, hydrophilic gel skeleton, bleaching aid and / or adhesive agent, expansion agent and regulator, and part of the glidant to obtain a mixture;

[0051] Step S03: monitor the moisture content of the mixture;

[0052] Step S04: Sieve and granulate the mixture that meets the moisture monitoring requirements, then mix it with the weighed remaining glidant, and then carry out formulation shaping treatment.

[0053] Wherein, the components contained in the gastric retention composition and the content of each component in the above st...

Embodiment 1

[0062] Embodiment 1 (dry granulation)

[0063] This embodiment provides a gastric retention composition and a preparation method thereof. The gastric retention composition comprises the following components by weight:

[0064] Ratoxine, HPMC, NaHCO 3 , Cetyl Alcohol, Sodium Starch Carboxymethyl, Citric Acid, Micronized Silica Gel. Its weight ratio is 25:100:25:60:30:25:5.

[0065] The preparation method of the gastric retention composition of the present embodiment is as follows:

[0066] S11: According to the ratio of each component of the gastric retention composition in this embodiment, weigh radishin and the above-mentioned auxiliary materials;

[0067] S12: Fully mix the weighed rapaidulin, regulator, and micropowder silica gel, then add hydrophilic gel skeleton, bleaching aid, expansion agent, etc., fully mix, and pass through a 60-mesh sieve to obtain a mixed material;

[0068] S13: Dry granulating the mixed material to prepare a dosage form green body;

[0069] S...

Embodiment 2

[0071] Embodiment 2 (direct compression tablet)

[0072] This embodiment provides a gastric retention composition and a preparation method thereof. The gastric retention composition comprises the following components in parts by weight: radish, HPMC, NaHCO 3 , Cetyl Alcohol, Sodium Starch Carboxymethyl, Citric Acid, Micronized Silica Gel. Its weight ratio is 25:100:25:60:30:25:5.

[0073] The preparation method of the gastric retention composition of the present embodiment is as follows:

[0074] S11: According to the ratio of each component of the gastric retention composition in this embodiment, weigh radishin and the above-mentioned auxiliary materials;

[0075] S12: Fully mix the weighed rapaidulin, regulator, and micropowder silica gel, then add hydrophilic gel skeleton, bleaching aid, expansion agent and other auxiliary materials, fully mix, and pass through a 60-mesh sieve to obtain a mixed material ;

[0076] S13: Carry out moisture monitoring, so that the moistur...

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Abstract

The invention relates to a raphanin composition preparation, and in particular to a raphanin gastric retention composition, belonging to the technical field of medicinal preparations. The gastric retention composition consists of 1-100 parts by weight of raphanin which serves a medicinal component, and medicinal adjuvants include the following components in parts by weight: 15-100 parts of a hydrophilic gel skeleton, 10-200 parts of a bleaching auxiliary and / or an adhesive, 10-100 parts of an expanding agent, 10-100 parts of a regulating agent and 0-50 parts of a flow aid. With the application of the gastric retention composition, gastric retention time can be prolonged, and an effect of implementing sustained release of the raphanin can be achieved, so that decomposition of the raphanin is relieved, an effective therapeutic concentration and action duration of the raphanin at a target site are kept, and bioavailability and efficacy are improved. According to a preparation method which adopts a dry process, the raphanin is prevented from getting into contact with water, so that a drying step is omitted and the stability of the raphanin in the process (the method) is enhanced; and the preparation method is applicable to industrial production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a gastric retention composition containing radishene and a preparation method thereof. Background technique [0002] Helicobacter pylori (Hp) is an independent risk factor for peptic ulcer and is closely related to the occurrence and development of gastric cancer. In 1994, the International Agency for Research on Cancer (IARC) of the World Health Organization listed it as a class I carcinogen. According to a survey, more than half of the world's population has been infected with Helicobacter pylori, and the infection rate of Hp in China is about 54.76%, and the infection rate in some areas is as high as 90%. This bacterial infection first causes chronic gastritis, leading to gastric ulcer and gastric atrophy, and in severe cases, it develops into gastric cancer. Accordingly, experts believe that early detection of Helicobacter pylori infection and...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/145A61K47/38A61K47/32A61K47/36A61P31/04A61P35/00
CPCA61K9/0065A61K9/0002A61K9/2009A61K9/2013A61K9/2054A61K9/2059A61K9/2095A61K31/145
Inventor 梁少瑜曾永长吴正治
Owner SHENZHEN ELDERLY MEDICAL RES INST
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