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Direct oral decoction pieces of Chinese medicine of sunset abelmoschus flower powder

A technology for decoction pieces of traditional Chinese medicine and hollyhocks, which is applied in the field of medicine and can solve problems such as damage to chemical properties, complex chemical components, and nuclear material residues.

Pending Publication Date: 2017-11-24
江苏苏轩堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Physical sterilization methods such as dry heat, high temperature and high pressure steam, chemical sterilization methods such as ethylene oxide, and gamma ray sterilization methods such as cobalt-60 all have major defects, and some of the sterilization methods have poor sterilization effects. Some destroy the active ingredients contained in traditional Chinese medicine and change some of their chemical properties, some leave nuclear residues, and some have pollution factors, etc.
[0009] Direct oral Chinese herbal decoction pieces are a new type of modern Chinese herbal decoction pieces that have just been defined by the state in recent years. In addition to the microbial limit standards for direct oral decoction pieces listed in the fourth part of the "Chinese Pharmacopoeia" 2015 edition, there is still no national unified quality enforcement of direct oral Chinese herbal medicine decoction pieces. standard, and hollyhock pollen products are no exception
In addition, because the chemical components contained in each herb are very complex, and the quality varies from place to place, the content quality requirements are often based on the content of its index components or active components reaching a certain value (except for toxic components), plus Most of the active ingredients are stored in its cells. For various reasons, as a medicine, hollyhock pollen has not yet had a statistical and scientific "expiration date"

Method used

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  • Direct oral decoction pieces of Chinese medicine of sunset abelmoschus flower powder
  • Direct oral decoction pieces of Chinese medicine of sunset abelmoschus flower powder
  • Direct oral decoction pieces of Chinese medicine of sunset abelmoschus flower powder

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0059] Preparation of reference substance solution Take an appropriate amount of hyperin reference substance, weigh it accurately, add methanol to make a solution containing 0.1mg per 1ml, and obtain it.

[0060] Preparation of the test solution Take about 0.5g of the fine powder of this product, weigh it accurately, put it in a stoppered conical flask, add 50ml of methanol accurately, weigh it, heat it under reflux for 1 hour, let it cool, weigh it again, and use Make up the lost weight with methanol, shake well, filter, and take the subsequent filtrate, that is, the obtained product.

[0061] Determination method Accurately draw the reference substance solution and the test solution respectively 10μl, inject the liquid chromatograph, measure, that is.

[0062] This product is calculated as a dry product, containing hyperin (H 21 h 20 o 12 ) shall not be less than 0.50%.

[0063] The polysaccharide content of the marshmallow flower was measured according to the determinat...

Embodiment 1

[0077] 120 kilograms of raw medicinal materials of hollyhock flower were divided into 3 experimental batches (40.0 kilograms per batch), which were purified, dried and crushed according to the drug GMP standard (D-level clean area, dust-absorbing low-temperature crushing technology was used, and crushed separately) into 80, 100, 120 mesh), intermediate (inspection), quantitative packaging (3 g / bag, D-level clean area), electron beam irradiation sterilization (30% of the remaining quantitative packaging in each batch is not sterilized operation), the resulting product (test sample) is used for the best GMP production process of hollyhock pollen of the present invention and its quality standard experimental research.

[0078] 1. The optimal production process of "Hullhock pollen" directly orally in Chinese herbal medicine:

[0079] (1) Optimum fineness (mesh number) production process:

[0080] The size of the rhizome cells of the hollyhock flower is more than ten to tens of mi...

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Abstract

The invention provides direct oral decoction pieces of Chinese medicine of sunset abelmoschus flower powder. The preparation technology of the direct oral decoction pieces of the Chinese medicine of the sunset abelmoschus flower powder comprises the following steps that (1) a sunset abelmoschus flower raw medicinal material is tested, cleansed and dried and then smashed, and an intermediate is obtained; (2) the intermediate is tested, and after packaging is conducted, E-beam radiation sterilization is conducted; (3) finished product standard testing is conducted, and after packaging is conducted, a finished product is obtained; and, specifically, in the step (1), the smashing condition is that in a D-level clean area, the sunset abelmoschus flower raw medicinal material is smashed to be 120 meshes by applying a dust-collecting-type low-temperature smashing technology, and in the step (2), the irradiation dose of E-beam radiation sterilization is 3-10 kGy. According to the direct oral decoction pieces of the Chinese medicine of the sunset abelmoschus flower powder, compared with a fine powder standard (120 meshes) of the 'China Pharmacopeia', the total amount of water extracts of sunset abelmoschus flower powder products is increased by over 50%, the digestion total amount of polysaccharide in the water extracts is increased by over 20%, the digestion total amount of hyperoside in the water extracts is increased by over 35-40%, and a microbial limit testing result can completely accord with the related standards of direct oral decoction pieces.

Description

technical field [0001] The invention relates to a traditional Chinese medicine decoction piece for direct oral administration of hollyhock pollen, which belongs to the technical field of medicine. Background technique [0002] It is the dry corolla of Abelmoschus manihot (L.) Medic, a plant of Malvaceae. Pick when the flowers bloom in summer and autumn, and dry them in time. Hollyhock, also known as: yellow sunflower, side calendula, okra, cotton sunflower, okra, golden flower, water cotton, cotton seven, cotton Artemisia, small cotton, stream hemp, wild hibiscus, wild beetle. Annual or perennial stout erect herb, 1-2 meters high. Stems covered with yellow setae. The leaves are large, ovate to nearly round, 15-30 cm in diameter or more, palmately divided, with 5-9 long and narrow lobes of various sizes, with teeth on the edge; petiole 6-18 cm long. Flowers solitary in leaf axils and branches, forming nearly racemes; bracts linear-lanceolate or lanceolate, 4-5 pieces, abo...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/14A61L2/08
CPCA61K9/0053A61K9/14A61K36/185A61K2236/15A61K2236/17A61L2/007A61L2202/21
Inventor 邓京振周建平陈杰
Owner 江苏苏轩堂药业有限公司