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Preparation method of self-repairing hydrogel type dressing material based on layer-by-layer assembly function

A layer-by-layer self-assembly and self-healing technology, applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of mechanical properties decline, shorten the service life of materials, affect the normal use performance of materials, etc., and achieve easy operation. , good antibacterial properties, excellent self-healing properties

Inactive Publication Date: 2017-11-24
临沂市人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] By improving the mechanical properties of materials, the service life of materials can be extended to a certain extent. However, even materials with good mechanical properties will inevitably produce local damage and microcracks during use and under the influence of the surrounding environment, resulting in mechanical damage. Performance decline, affecting the normal performance of the material and shortening the service life of the material

Method used

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  • Preparation method of self-repairing hydrogel type dressing material based on layer-by-layer assembly function
  • Preparation method of self-repairing hydrogel type dressing material based on layer-by-layer assembly function

Examples

Experimental program
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Effect test

Embodiment 1

[0027] A method for preparing a self-repairing hydrogel dressing material based on layer-by-layer self-assembly function, which comprises the following steps:

[0028] 1) Adjust the concentration of CS aqueous solution to 1mg / mL, pH to 3, and set aside; adjust the concentration of HA aqueous solution to 6mg / mL, pH to 6, and set aside;

[0029] 2) Immerse the base material in the CS aqueous solution obtained in step 1), take it out after 5-15 minutes, and rinse with distilled water;

[0030] 3) Immerse the substrate material treated in step 2) into the HA aqueous solution prepared in step 1) for 5-15 minutes, take it out and rinse it with distilled water;

[0031] 4) Repeat steps 2) and 3) to repeatedly assemble multilayer polyelectrolyte materials on the surface of the substrate to obtain a self-healing hydrogel dressing material with antibacterial properties;

[0032] 5) Soak the self-healing hydrogel dressing material prepared in the above step 4) into the roxithromycin@bPE...

Embodiment 2

[0035] A method for preparing a self-repairing hydrogel dressing material based on layer-by-layer self-assembly function, which comprises the following steps:

[0036] 1) Adjust the concentration of the CS aqueous solution to 3 mg / mL and the pH to 5 for standby; adjust the concentration of the HA aqueous solution to 4 mg / mL and the pH to 9 for standby;

[0037] 2) Immerse the base material in the CS aqueous solution obtained in step 1), take it out after 5-15 minutes, and rinse with distilled water;

[0038] 3) Immerse the substrate material treated in step 2) into the HA aqueous solution prepared in step 1) for 5-15 minutes, take it out and rinse it with distilled water;

[0039] 4) Repeat steps 2) and 3) to repeatedly assemble multilayer polyelectrolyte materials on the surface of the substrate to obtain a self-healing hydrogel dressing material with antibacterial properties;

[0040] 5) Soak the self-healing hydrogel dressing material prepared in the above step 4) into a n...

Embodiment 3

[0043]A method for preparing a self-repairing hydrogel dressing material based on layer-by-layer self-assembly function, which comprises the following steps:

[0044] 1) Adjust the concentration of CS aqueous solution to 6mg / mL, pH to 4, and set aside; adjust the concentration of HA aqueous solution to 1mg / mL, pH to 8, and set aside;

[0045] 2) Immerse the base material in the CS aqueous solution obtained in step 1), take it out after 5-15 minutes, and rinse with distilled water;

[0046] 3) Immerse the substrate material treated in step 2) into the HA aqueous solution prepared in step 1) for 5-15 minutes, take it out and rinse it with distilled water;

[0047] 4) Repeat steps 2) and 3) to repeatedly assemble multilayer polyelectrolyte materials on the surface of the substrate to obtain a self-healing hydrogel dressing material with antibacterial properties;

[0048] 5) Load broad-spectrum antibacterial drugs (such as erythromycin, spiramycin, etc.) into the dressing materia...

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Abstract

The invention discloses a preparation method of a self-repairing hydrogel type dressing material based on a layer-by-layer assembly function. The hydrogel dressing material is controllably constructed by selecting the optimal assembly elements, utilizing the advantages of a layer-by-layer assembly technology on constructing a gel membrane material, and adjusting the optimal assembly conditions (acid-base value, ion strength, solvent, etc.). Furthermore, based on the layer-by-layer assembly technology, target substances with different properties and performances can be assembled to the dressing material through many modes, and the target substances can be controllably released. The prepared dressing material has the following characteristics: (1) the dressing material has a strong dressing performance and excellent biocompatibility and thus is an ideal wet dressing material; (2) the dressing material has an excellent controlled release function and is capable of precisely releasing loaded drugs under specific incentive conditions; and (3) the dressing material has an excellent self-repairing performance and can repair damaged parts rapidly, the service life is prolonged, and the secondary damage caused by replacement is avoided.

Description

technical field [0001] The invention relates to a method for preparing a self-healing hydrogel dressing material based on layer-by-layer assembly functions. By screening the optimal assembly primitives and adjusting the optimal assembly conditions (pH, ionic strength, solvents, etc.) The controllable construction of the gel film material can improve the antibacterial performance of the material, greatly improve the service life of the dressing material, and reduce the secondary damage caused by replacement, which belongs to the technical field of biomedical materials. Background technique [0002] A medical dressing is a protective covering over a wound to help control bleeding, prevent infection, and absorb secretions. Traditional wound dressings are mainly gauze, bandages, cotton, etc., which can provide wounds with layer-by-layer assembly of therapeutic drugs, stop bleeding, prevent water, electrolytes, and other foreign substances from stimulating, and accelerate wound h...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/46A61L15/62A61K8/73A61K8/02A61Q19/00
CPCA61K8/0212A61K8/735A61K8/736A61L15/28A61L15/46A61L15/62A61L2300/232A61L2300/404A61Q19/00C08L5/08
Inventor 王丽娟朱彦熹王龙王志强
Owner 临沂市人民医院
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