Single-view Cerenkov luminescence tomography reconstruction method

Abstract

The invention belongs to the technical field of optical molecular imaging, and discloses a single-view Cerenkov luminescence tomography reconstruction method. The method comprises: detecting surface optical information of a detected object by using an optical camera; acquiring organism organization structure information and optical property parameters; mapping two-dimensional optical data acquired by the optical camera to an organism surface to obtain three-dimensional fluorescent data distribution of the organism surface; establishing a linear relation between measured data of the surface and an internal unknown light source by using anatomical structure information of a reconstructed object and the optical property parameters as prior information; reconstructing a grid all domain via a sparse Bayesian learning algorithm to realize three-dimensional distribution of radionuclide probes inside a target; and performing image fusion and display on the reconstruction result and the anatomical structure of the imaged object. The method effectively improves the Cerenkov tomography reconstruction result, and has important application value in the fields of optical tomography three-dimensional reconstruction algorithms and the like.

Description

technical field [0001] The invention belongs to the technical field of optical molecular imaging, and in particular relates to a single-view Cerenkov luminescence tomography reconstruction method. Background technique [0002] The Cherenkov effect refers to the phenomenon that when a high-speed charged particle moves in a conductive medium and its speed exceeds the phase velocity of light in the medium, it emits spectrally continuous near-infrared light and visible light. This phenomenon was discovered by former Soviet physicist Cherenkov in 1934 and won the Nobel Prize in Physics in 1958. In 2009, Roberson et al. collected the Cerenkov radiation emitted by the radionuclide probe 18F-deoxyglucose (18F-FDG) for the first time using an optical instrument (OI), and named it Cherenkov luminescence Imaging (Cerenkov Luminescence Imaging, CLI). In recent years, with the development of high-sensitivity CCD cameras and a large number of clinically available radionuclide probes, Ce...

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Problems solved by technology

[0003] To sum up, the problems existing in the existing technology are: in order to improve the accuracy of the CLT reconstruction results, the existing technology has a large amount of data, time-consuming, high cost, and limited angles when collecting data, resulting in an excessive amount of calculation. Appropriate reconstruction algorithms to alleviate the ill-posed nature of the inverse problem become the core

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