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Oral care product containing sodium gualenate and preparation method thereof

A technology for sodium azulene sulfonate and oral products, which is applied in the field of oral products containing sodium azulene sulfonate and its preparation, and can solve the problems of no oral composition

Inactive Publication Date: 2017-12-01
CHONGQING DENCARE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although sodium azulene sulfonate and dipotassium glycyrrhizinate are commonly used raw materials in toothpaste, there is no oral composition combining sodium azulene sulfonate and dipotassium glycyrrhizinate at present. The combination ratio of sodium sulfonate and dipotassium glycyrrhizinate has been studied, and the optimal antibacterial and anti-sensitivity treatment effect has been achieved.

Method used

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  • Oral care product containing sodium gualenate and preparation method thereof
  • Oral care product containing sodium gualenate and preparation method thereof
  • Oral care product containing sodium gualenate and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] In the first step, add 10g of moisturizing agent glycerin, then add 0.7g of binder sodium carboxymethylcellulose, stir quickly and homogenize, then add 35g of sweetener sorbitol, 0.4g of sodium saccharin, and 0.001g of sodium azulenesulfonate , dipotassium glycyrrhizinate 0.01g, potassium nitrate 0.01g, surfactant sodium lauryl sulfate 2g, antiseptic sodium benzoate 0.3g, and stir evenly;

[0043] In the second step, vacuumize and add 24 g of friction agent silicon dioxide, stir and homogenize;

[0044] In the third step, add 1g of mint essence, stir and homogenize, degas, and the toothpaste is finished.

Embodiment 2～ Embodiment 8

[0045] Except for the differences in Table 1 and Table 2, the preparation methods of Example 2 to Example 8 and Comparative Example 1 to Comparative Example 7 are the same.

[0046] Experiment 1: Antibacterial test

[0047] Candida albicans (C.a) can cause thrush, oral ulcer etc., Porphyromonas gingivalis (P.g) is the main bacterium that causes periodontitis, utilizes the embodiment 1~implementation of evaluation table 1, table 2 by disc diffusion method Example 8, the antibacterial potential of the toothpastes of Comparative Examples 1 to 7 to Candida albicans and Porphyromonas gingivalis. The operation steps are as follows: Incubate the concentration of P.g with 1.5×10 6 The CFU / mL bacterial suspension was picked up with an inoculation loop and evenly cross-coated on the BHIA, a total of 15. will be incubated with a concentration of C.a of 1.0 x 10 7 The cells / mL bacterial suspension was picked with an inoculation loop and spread evenly on the Sabouraud dextrose agar medium...

Embodiment 9

[0067] Now with the embodiment 9 of a kind of oral product mouthwash containing sodium azulene sulfonate of the present invention, illustrate the preparation method of the present invention:

[0068] The preparation steps are:

[0069] Step 1: First mix 5.5g of moisturizing agent glycerin, 79.289g of water, and 0.2g of sweetener neotame to form a water phase.

[0070] Step 2: Add 0.001g of sodium azulene sulfonate, 0.01g of dipotassium glycyrrhizinate, 0.01g of potassium nitrate, 1g of mint essence, 12g of sorbitol, and 2g of poloxamer and mix until there is no turbidity. Slowly add the water phase, filter and divide, and the preparation of mouthwash is completed.

[0071] Experiment 1: Antibacterial test

[0072] Select Candida albicans and Porphyromonas gingivalis to carry out antibacterial experiment to the mouthwash of embodiment 9~embodiment 16, comparative example 8~comparative example 14 of table 5, table 6, experimental method is according to " technical specificatio...

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Abstract

The invention discloses an oral care product containing sodium gualenate. The oral care product is mainly prepared from the raw materials in parts by mass: 0.001 to 3 parts of sodium gualenate, 0.01 to 8 parts of dipotassium glycyrrhizinate, and 0.01 to 10 parts of potassium nitrate. The invention aims to solve the technical problem so as to provide the oral care product containing sodium gualenate with optimal antibacterial and anti-allergen effects, and a preparation method thereof.

Description

technical field [0001] The invention relates to the technical field of dental preparations, in particular to an oral product containing sodium azulene sulfonate and a preparation method thereof. Background technique [0002] The oral cavity is a window to observe the state of the whole body. If oral diseases are not treated in time, it will cause various complications in the body. With the improvement of living standards, more and more people begin to pay attention to oral health. Common oral diseases include oral ulcers, periodontal disease and dental caries. Oral ulcer is a kind of limited ulcer injury of localized oral ulcers characterized by periodic recurrent attacks, which can occur in any part of the oral mucosa. The clinical symptoms are salivation, loss of appetite or slow food intake, oral odor, oral Flushing, warmth, swelling and pain. Periodontal disease mainly refers to gingivitis and periodontitis; gingivitis refers to acute and chronic inflammation that occu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/63A61K8/46A61K8/19A61Q11/00A61P1/02A61P37/08A61P31/02A61P31/10A61P31/04A61P7/04
CPCA61K8/63A61K8/19A61K8/466A61Q11/00
Inventor 田政张环蒋玮邓嵘陈欣
Owner CHONGQING DENCARE CORP
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