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Preparation method for three-dimensionally printing biological ceramic scaffold by using a biological ceramic ink

A technology of bioceramics and three-dimensional printing, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of immune rejection and disease transmission in allogeneic transplantation, and achieve the avoidance of scaffold structure distortion, high biocompatibility, Energy Saving Effect

Inactive Publication Date: 2017-12-05
苏州拜博机电科技有限公司
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Allogeneic transplantation is prone to immune rejection and also has the risk of spreading diseases

Method used

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  • Preparation method for three-dimensionally printing biological ceramic scaffold by using a biological ceramic ink
  • Preparation method for three-dimensionally printing biological ceramic scaffold by using a biological ceramic ink

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1, the preparation of hydroxyapatite mud, are as follows:

[0033] Take an appropriate amount of egg shells, wash them with tap water and dry them, use 2% acetic acid to clear the egg shells, and dry them in an oven at 60°C;

[0034] In a ball mill, use zirconia as a grinding medium to grind eggshells for 2 hours at high speed. 100 μm filter to filter powder;

[0035] Weigh 10 grams of egg shells, add 50 grams of 85% orthophosphoric acid, and leave overnight at room temperature to prepare hydroxyapatite slurry.

example 2

[0036] Example 2, the preparation of bioceramic ink, are as follows:

[0037] The silk fibroin solution prepared by degumming silk for 10 minutes, 30 minutes and 1 hour was placed in a refrigerator at 4°C for 24 hours, dried with cold air at 10°C for 48 hours, and ventilated and dried at room temperature for 24 hours to obtain 15%~30% (wt / wt) silk prime solution;

[0038] Add the hydroxyapatite slurry prepared above to the silk fibroin solution to obtain bioceramic ink, the ratio is 1:1~1:9;

[0039] Example 3, three-dimensional controllable microstructure bioceramic scaffold preparation, refer to figure 1 , figure 2 ,details as follows:

[0040] Place the bioceramic ink in the syringe, select a needle with a wedge-shaped inner cavity, 20G, to obtain the bioceramic ink;

[0041] Load the print model (.STL) designed by SolidWorks into Repetier software, and use the Silcs plug-in to layer the model;

[0042] Bioceramic inks form three-dimensional ceramic scaffolds with dif...

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PUM

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Abstract

The invention belongs to the technical field of three-dimensional printing, and specifically discloses a preparation method for three-dimensionally printing a biological ceramic scaffold by using a biological ceramic ink. According to the present invention, hydroxyapatite is prepared by using egg shell as a calcium source, and the excellent mechanical property and the excellent biological characteristics of the silk fibroin are supplemented to obtain the three-dimensional scaffold with characteristics of controlled internal components and controlled shape structure, such that the problem that the biological model ceramic bone repair body cannot be precisely customized in a personalized manber in the clinic can be solved.

Description

technical field [0001] The invention relates to the technical field of three-dimensional printing, in particular to a preparation method for three-dimensional printing bioceramic ink to prepare a bioceramic support. Background technique [0002] Silk is mainly composed of two proteins, sericin and silk fibroin. Mulberry silk core-shell structure, the outer layer is coated with sericin (Sericin), and the inner layer is silk fibroin (Silk Fibroin), in which the content of silk fibroin is 70 ~ 80%, the H chain of silk fibroin is 390 KD, and the H chain of 25 KD The L chain and 30 KD of P25 composition. Regenerated silk fibroin can be prepared into various forms of biomaterials, such as films, gels, scaffolds, and particles, for drug carriers, composition engineering repairs, and immobilized enzyme preparations. [0003] Hydroxyapatite, also known as hydroxyapatite, basic calcium phosphate, is the natural mineralization of calcium apatite (Ca5(PO4)3(OH)). But it is often writ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/22A61L27/12A61L27/36
CPCA61L27/12A61L27/227A61L27/3604A61L27/365A61L2430/02C08L89/00
Inventor 郑兆柱刘萌王小锋于凯
Owner 苏州拜博机电科技有限公司
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