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Preparation method of indometacin loaded nanofiber composite material

A technology loaded with indomethacin and nanofibers, which is applied to medical preparations containing non-active ingredients, medical preparations containing active ingredients, drug combinations, etc., can solve the problem of low relative amount and achieve ecological environment protection and activity Strong, productivity-enhancing effect

Active Publication Date: 2017-12-08
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In actual production, liposomes are often used as the carrier of indomethacin, but their shortcomings are obvious, and the relative amount of them entering the human circulation is not high

Method used

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  • Preparation method of indometacin loaded nanofiber composite material

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Comparison scheme
Effect test

Embodiment 1

[0028] A method for preparing a nanofiber composite material loaded with indomethacin, comprising the following steps: nanofibers and ε-caprolactone undergo a composite reaction to prepare a nanofiber composite material, and 10 parts by weight of the nanofiber composite material and 1 weight part Parts of indomethacin are sequentially dissolved in a mixture of tetrahydrofuran and acetonitrile to obtain a mixture, and the mixture is volatilized and dried to obtain a nanofiber composite material loaded with indomethacin;

[0029] Wherein, the mixed solution of tetrahydrofuran and acetonitrile is prepared by mixing tetrahydrofuran and acetonitrile in a volume ratio of 2:1;

[0030] Described nanofiber is banana cellulose nanofiber, and it is made by following steps:

[0031] S1. Put the banana stem fibers in a mixed solution of toluene and absolute ethanol, and reflux and extract at 120° C. for 3 hours to obtain a turbid solution. The turbid solution is cooled and allowed to stan...

Embodiment 2

[0035] The preparation method of the nanofiber composite material loaded with indomethacin comprises the following steps: the nanofiber composite material is prepared through composite reaction between nanofiber and ε-caprolactone, and 20 parts by weight of the nanofiber composite material and 2 parts by weight Parts of indomethacin are sequentially dissolved in a mixture of tetrahydrofuran and acetonitrile to obtain a mixture, and the mixture is volatilized and dried to obtain a nanofiber composite material loaded with indomethacin;

[0036]Wherein, the mixed solution of tetrahydrofuran and acetonitrile is prepared by mixing tetrahydrofuran and acetonitrile in a volume ratio of 2:1;

[0037] Described nanofiber is banana cellulose nanofiber, and it is made by following steps:

[0038] S1. Put the banana stem fiber into the mixed solution of toluene and absolute ethanol, and reflux and extract at 120° C. for 4 hours to obtain a turbid solution. The turbid solution is separated...

Embodiment 3

[0043] A method for preparing a nanofiber composite material loaded with indomethacin, comprising the following steps: nanofibers and ε-caprolactone undergo a composite reaction to prepare a nanofiber composite material, and 30 parts by weight of the nanofiber composite material and 3 parts by weight Parts of indomethacin are sequentially dissolved in a mixture of tetrahydrofuran and acetonitrile to obtain a mixture, and the mixture is volatilized and dried to obtain a nanofiber composite material loaded with indomethacin;

[0044] Wherein, the mixed solution of tetrahydrofuran and acetonitrile is prepared by mixing tetrahydrofuran and acetonitrile in a volume ratio of 2:1;

[0045] Described nanofiber is banana cellulose nanofiber, and it is made by following steps:

[0046] S1. Put the banana stem fiber in the mixed solution of toluene and absolute ethanol, and reflux and extract at 120°C for 5 hours to obtain a turbid solution. The turbid solution is separated after cooling...

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Abstract

The invention discloses a preparation method of an indometacin loaded nanofiber composite material. The preparation method comprises the following steps: carrying out composite reaction on nanofiber and epsilon-caprolactone, thus obtaining a nanofiber composite material; sequentially dissolving 10 to 30 parts by weight of the nanofiber composite material and 1 to 3 parts by weight of indometacin into a mixed solution of tetrahydrofuran and acetonitrile, thus obtaining a mixture; volatizing and drying the mixture, thus obtaining the indometacin loaded nanofiber composite material. According to the preparation method disclosed by the invention, banana stalk fiber is used as a raw material for preparing the nanofiber composite material, the nanofiber composite material is utilized as a lead-in carrier of the indometacin, waste is changed into wealth, reasonable utilization of resources is realized, high-efficiency and low-cost medicine can be prepared, and good economic benefit is obtained.

Description

technical field [0001] The invention relates to the field of novel utilization of plant fibers. More specifically, the present invention relates to a method for preparing a nanofiber composite material loaded with indomethacin. Background technique [0002] Banana fiber uses banana stems as raw materials and is mainly composed of cellulose, hemicellulose and lignin. The fiber after chemical degumming can be used for cotton spinning. The fiber made after drying, scouring and defibration has the functions of light weight, good luster, high water absorption, strong antibacterial property, easy degradation and environmental protection. Japan is at the forefront of research on banana fiber, and Southeast Asian countries rich in banana resources, such as India, have also conducted a lot of research. China's extraction and product development of this fiber are also in progress, and some progress has been made. The successful production of banana fiber has greatly expanded the app...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/405A61K47/38A61K47/34A61P29/00
CPCA61K9/7007A61K31/405A61K47/34A61K47/38
Inventor 庞锦英谭登峰蓝春波莫羡忠刘钰馨李建鸣袁广志