Skin medicine composition with azulene sulfonate

A technology of a composition and azulene sulfonic acid, which can be used in drug combinations, medical preparations containing active ingredients, skin diseases, etc., and can solve problems such as pigmentation, telangiectasia, and skin atrophy and thinning

Inactive Publication Date: 2017-12-29
TIANJIN JINYAO GRP
View PDF4 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While glucocorticoids have a strong curative effect, there are also adverse reaction...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Skin medicine composition with azulene sulfonate
  • Skin medicine composition with azulene sulfonate
  • Skin medicine composition with azulene sulfonate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Embodiment 1 suspension

[0051] Active ingredient list

[0052]

[0053] Adjuvant prescription and preparation method of embodiment 1

[0054] Appropriate amount of sodium chloride, sodium carboxymethylcellulose 2.5g, poloxamer 0.5g, add distilled water to 1000g

[0055] Preparation method: dissolve the carboxymethylcellulose sodium and poloxamer of the prescribed amount in 500ml water for injection, stir to dissolve, add the azulene sulfonic acid compound of the prescribed amount; then add the glucocorticoid drugs of the prescribed amount, Add the remaining amount of water for injection. Adjust to isotonicity with sodium chloride and dispense.

Embodiment 1

[0057] According to the adjuvant prescription and preparation method in Example 1, prepare azulene sulfonic acid compound suspension and glucocorticoid drug suspension respectively, the number of comparative example 1 corresponds to the number of Example 1, according to the activity used The components are different, and the end number of the comparative examples is increased by G (glucocorticoid drugs) or Y (azulene sulfonic acid compounds). For example, the active ingredients of Example 1-1 are G1 (1g) and Y1 (1g), while the active ingredients of Comparative Example 1-1-G are glucocorticoids (no azulene sulfonic acid drugs), and the active ingredients are G1 (1 g), the active ingredient of the suspension 1-1-Y of the comparative example is azulene sulfonic acid drugs (no glucocorticoid drugs), and the active ingredient is Y1 (1 g).

Embodiment 2

[0058] Embodiment 2 gel

[0059] Active ingredient list

[0060]

[0061] Adjuvant prescription and preparation method of embodiment 2

[0062] See the above table for the dosage of active ingredients glucocorticoids and azulene sulfonic acids

[0063] Polyethylene glycol 600-100g, propylene glycol 100g, absolute ethanol 100g, carbomer 93430g, appropriate amount of triethanolamine, add distilled water to 1000g.

[0064] Preparation method: Sprinkle Carbomer 934 evenly on the surface of 300ml distilled water, let it stand still to make it fully swell; mix the prescribed amount of glucocorticoids and azulene sulfonic acid drugs with absolute ethanol, and then add Prescription measures of water, macrogol 600, and propylene glycol. Mix and stir the above components, slowly add triethanolamine dropwise, stir while adding, control pH 6.0-7.0, and then pack it separately.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a medicine composition which consists of active components and medicinal auxiliary materials and can directly act on skin. The medicine composition is characterized in that the active components comprise one of glucocorticoids and azulene sulfonate or one of salts of azulene sulfonate.

Description

technical field [0001] The invention relates to a pharmaceutical composition directly acting on the skin composed of active components and pharmaceutical auxiliary materials, characterized in that the active components contain one of glucocorticoids and one of azulenesulfonic acid or its salts. Background technique [0002] Glucocorticoids are a type of steroidal corticosteroids. They have a steroidal compound structure and can inhibit inflammation and allergic skin reactions. At the same time, they can also inhibit reactions associated with accelerated cell regeneration and cause symptoms such as erythema, edema, and thick skin. Thinning, reduction of surface roughness of the skin, and relief of itching, burning, and pain. Since ester groups are introduced into these compounds, especially at the 21 and / or 17 positions of the pregnant compounds, their fat solubility is better, so that better curative effect can be achieved in external treatment. Corticosteroids include hydr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K45/06A61K31/185A61K31/58A61K31/573A61P17/04A61P17/00A61P17/06
CPCA61K31/185A61K31/573A61K31/58A61K45/06A61K2300/00
Inventor 孙亮
Owner TIANJIN JINYAO GRP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap