Antibacterial absorbable surgical suture and method for preparing same

A surgical suture and antibacterial technology, applied in the field of medical devices, can solve the problems of increasing the incidence of surgical site infection, increasing the economic burden of patients, and easy adsorption and hiding of bacteria, so as to avoid inflammation and wound infection, promote wound healing, and effectively Good for degradation and absorption

Inactive Publication Date: 2017-12-29
云智前沿科技发展(深圳)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the suture thread is a channel for bacteria to enter the surgical incision, and it is easy to absorb and hide bacteria, which increases the incidence of surgical site infection
Therefore, inappropriate surgical sutures not only affect wound healing and bring pain to patients, but also increase the economic burden on patients and society

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0036] The preparation method of the antibacterial absorbable surgical suture thread of the present invention comprises prolamin dissolution, mixed oleic acid, preparation of silk-forming stock solution, preparation of silk and post-processing steps, the specific steps are as follows:

[0037] A. Dissolving gliadin: Add cereal gliadin into ethanol aqueous solution, stir until most of gliadin dissolves, and obtain gliadin mixture;

[0038] B. Mixed oleic acid: add oleic acid to the above prolamin mixture, stir at a constant temperature of 50-70°C at a speed of 500-700rpm / min until the solution is uniform and transparent, and a mixed solution is obtained;

[0039] C. Preparation of silk-forming stock solution: add chitosan to the above-mentioned mixed solution, stir at a speed of 500-700 rpm / min for 40-90 min at 60-70 ° C under heat preservation conditions, and then cool to room temperature at normal temperature and pressure. Obtain the silk stock solution;

[0040] D. Preparat...

Embodiment 1

[0049] 1. Under normal temperature and pressure, weigh 10g of zein, dissolve it in 50ml of 80% (about 43g, density 0.85932 g / ml) ethanol-water solution, stir with a glass rod until most of the zein dissolves , to obtain a zein mixture;

[0050] 2. Add 7ml of oleic acid (about 6.24g, density 0.891 g / ml) into the above-mentioned zein mixture, stir in a constant temperature magnetic stirrer at 50-70°C at a speed of 600rpm / min until the solution is uniform and transparent, and get Mixed liquid;

[0051] 3. Add 5g of chitosan to the above-mentioned mixed solution, stir at a constant temperature magnetic stirrer at a speed of 600rpm / min for 60min under the condition of 60-70°C heat preservation, then cool to room temperature under normal temperature and pressure to obtain silk stock solution;

[0052] 4. Put the above-mentioned silk-forming stock solution into the thread-forming device, and squeeze the thread-forming stock solution into an ice-water bath containing 10% by weight o...

Embodiment 2

[0055] 1. Under normal temperature and pressure, weigh 9g of wheat prolamin, dissolve it in 50ml of 89.8% (about 41.5g, density 0.82992 g / ml) ethanol-water solution, stir with a glass rod until most of the wheat alcohol dissolves Dissolving the protein to obtain the wheat prolamin mixture;

[0056]2. Add 8ml of oleic acid (about 7.12g, density 0.891 g / ml) into the above wheat prolamin mixture, stir in a constant temperature magnetic stirrer at 50-70°C at a speed of 500rpm / min until the solution is uniform and transparent, and get Mixed liquid;

[0057] 3. Add 10 g of chitosan to the above-mentioned mixed solution, stir at a constant temperature magnetic stirrer at a speed of 500 rpm / min for 90 min at a temperature of 60 to 70° C., and then cool to room temperature at normal temperature and pressure to obtain silk stock solution;

[0058] 4. Put the above-mentioned silk-forming stock solution into the thread-forming device, and squeeze the thread-forming stock solution into a...

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Abstract

The invention discloses an antibacterial absorbable surgical suture and a method for preparing the same. The antibacterial absorbable surgical suture comprises, by weight, 90-110 parts of cereal alcohol-soluble proteins, 415-440 parts of ethanol aqueous solution, 10-100 parts of chitosan, 54-71 parts of oleic acid and 5-10 parts of glycerin. The method includes adding the cereal alcohol-soluble proteins into the ethanol aqueous solution and stirring and dissolving the cereal alcohol-soluble proteins in the ethanol aqueous solution to obtain mixed liquid; adding the oleic acid into the mixed liquid and stirring the oleic acid and the mixed liquid until uniform and transparent solution is obtained; adding the chitosan into the uniformly mixed solution, stirring the chitosan and the solution under heat-insulation conditions at the temperature of 60-70 DEG C for 40-90 min to obtain other solution and then cooling the other solution at the normal temperature under the normal pressure until the temperature of the other solution reaches the room temperature so as to obtain suture forming stock solution; filling suture forming devices with the suture forming stock solution, squeezing the suture forming stock solution into coagulating bath and coagulating and simultaneously stretching the suture forming stock solution to obtain sutures; coating the glycerin on the surfaces of the sutures, drying the sutures at the room temperature and sterilizing the sutures to obtain the antibacterial absorbable surgical suture. The antibacterial absorbable surgical suture and the method have the advantages that the antibacterial absorbable surgical suture is good in biocompatibility and degradability and free of toxic and side effects and is antibacterial, and inflammation and wound infection can be prevented.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and specifically relates to an antibacterial absorbable surgical suture with better biocompatibility, degradability, no toxic side effects, antibacterial, and avoiding inflammation and wound infection and a preparation method thereof . Background technique [0002] Surgical suture is a linear material used for human surgical suture. From the perspective of material development, it has gone through silk thread, catgut, chemical synthesis thread, and pure natural collagen suture, and is divided into absorbable thread and non-absorbable thread. Requirements for existing surgical sutures: maintain sufficient strength and flexibility during wound healing, and should be able to stretch to adapt to wound edema; no inflammation; no irritation or pathogenicity; easy to dye, sterilize, and disinfect etc.; it can form a safe and firm knot; it is easy to make, low in price, and can be mass-produced....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/06A61L17/14
CPCA61L17/06A61L17/14C08L89/00C08L5/08
Inventor 孙洪亮仇乐杜鑫石绮君刘爽贺婷婷张莹莹
Owner 云智前沿科技发展(深圳)有限公司
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