A new 18α-glycyrrhetinic acid derivative and its medical application
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- CHIA TAI TIANQING PHARMA GRP CO LTD
- Publication Date
- 2019-11-29
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Abstract
Description
technical field
[0001] The invention belongs to the technical field of medicine, and in particular relates to a new 18α-glycyrrhetinic acid derivative and its medical application. Background technique
[0002] Glycyrrhizin (GL) is an effective active ingredient extracted from licorice, which has various pharmacological effects such as anti-inflammatory, anti-allergic, and anti-biological oxidation. After research, glycyrrhizic acid is hydrolyzed by gastric acid or decomposed into glycyrrhetinic acid by β-glucuronidase in the liver, and then generates 3-epi-glycyrrhetinic acid and a small amount of 3-dehydroglycyrrhetinic acid in the enterohepatic circulation to produce pharmaceutical activity , so the effect of glycyrrhizic acid drugs is essentially the effect of glycyrrhetinic acid (Hao Fei, research progress of glycyrrhizic acid abroad, Chinese Pharmacy, 2001, 12 (8): 500-501).
[0003] Glycyrrhizic acid is a pentacyclic triterpene saponin. Due to the difference in the co...