Cosmetic compositions containing hyaluronic acid of different molecular weights
A technology of cosmetic composition and hyaluronic acid, which is applied in the direction of cosmetics, cosmetic preparations, dressing preparations, etc., and can solve problems such as difficult effects
Active Publication Date: 2021-12-17
AMOREPACIFIC CORP
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Problems solved by technology
[0006] However, in the above-mentioned registered patent No. 10-0852944, when the cross-linked hyaluronic acid nanoparticles with large molecular weight are dispersed in oil, the penetration into the stratum corneum of the skin is more uniform and easier than in water. On the contrary, hyaluronic acid The acid salt is water-soluble and can only exert its effect when dispersed in the water phase. Therefore, although hyaluronic acid with different molecular weights, different chemical structures and different types is included in the same dosage form, it is difficult to combine various hyaluronic acids. The effect that the ingredient has on the skin is fully displayed
Method used
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reference example 1
[0058] [Reference Example 1] Production Example 1 and Comparative Examples 1-6
[0059] 1. Preparation of cross-linked hyaluronic acid nanoparticles
[0060]Hyaluronic acid (number average molecular weight: 1,500,000) was dissolved in 0.1N sodium hydroxide aqueous solution, and PEGDA (polyethylene glycol diacrylate) crosslinking agent was added thereto, stirred and dissolved to form an aqueous solution. The oil phase is oil that is incompatible with water and has fluidity, preferably paraffin oil or hydrocarbon oil, and hydrocarbon oil is used in this embodiment. Here, according to the content disclosed in Korean Registered Patent No. 10-0852944 of the present applicant, cetyl PEG / PPG-10 / 1 polydimethylsiloxane (cetyl PEG / PPG-10 / 1 dimethicone), sorbitan sesquioleate, and PEG-30 dipolyhydroxystearate (polyethylene glycol (30) dipolyhydroxy stearate), dextrin palmitate / Dextrin Palmitate / Ethylhexanoate, Dextrin Palmitate / Ethylhexanoate was selected in this embodiment. Slowly ...
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Abstract
The present invention relates to a capsule containing a variety of hyaluronic acid components with different molecular weights and a cosmetic composition containing the above-mentioned capsules, in particular to the capsule inner phase containing cross-linked hyaluronic acid nanoparticles with large molecular weight and the capsule wall material containing Capsules of hydrolyzed hyaluronic acid with small molecular weight are mixed with the water phase dispersed with hyaluronic acid salt to prepare a cosmetic composition. acid, has an extremely moisturizing and regenerating effect on the skin.
Description
technical field [0001] The present invention relates to a capsule containing a variety of hyaluronic acid components with different molecular weights and a cosmetic composition containing the above-mentioned capsules, in particular to the capsule inner phase containing cross-linked hyaluronic acid nanoparticles with large molecular weight and the capsule wall material containing The capsules of hydrolyzed hyaluronic acid with small molecular weight are mixed with the water phase dispersed with hyaluronic acid salt to prepare a cosmetic composition. acid, has an extremely moisturizing and regenerating effect on the skin. Background technique [0002] Hyaluronic acid is a linear polymer polysaccharide formed by alternating combinations of β-D-N-acetylglucosamine and β-D-glucuronic acid. As we all know, hyaluronic acid is not only distributed in connective tissues such as subcutaneous tissue and cartilage tissue of mammals, but also exists in the vitreous body of the eye and t...
Claims
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IPC IPC(8): A61K8/73A61K8/11A61Q19/00
Inventor 白秉烈金恩美黄俊永
Owner AMOREPACIFIC CORP