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A kind of recombinant human interferon α1b vaginal expansion suppository and preparation method thereof

A technology of recombinant human interferon and vaginal expansive suppository, which is applied in the direction of drug combination, suppository delivery, pharmaceutical formulation, etc., can solve the problems of inability to exert the therapeutic effect of suppositories, waste, and reduced contact area of ​​active ingredients, so as to improve the therapeutic effect, The effect of reducing dosage and reducing frequency of administration

Active Publication Date: 2020-04-24
哈尔滨田美药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, recombinant human interferon α2b and its synergistic components are mixed and distributed in the matrix to form a drug-containing matrix. The contact area between the active ingredients and the human body is reduced and cannot be fully absorbed by the human body, resulting in a certain degree of waste. the best therapeutic effect of

Method used

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  • A kind of recombinant human interferon α1b vaginal expansion suppository and preparation method thereof
  • A kind of recombinant human interferon α1b vaginal expansion suppository and preparation method thereof

Examples

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Effect test

Embodiment 1

[0042] In this example, the vaginal expansion suppository includes, in parts by weight: 0.1 part of recombinant human interferon α1b, 15 parts of comfrey extract, 8 parts of Viola extract, 5 parts of amethyst extract, 5 parts, 35 parts of polylactic-co-glycolic acid copolymer, 120 parts of a mixture of synthetic fatty acid esters and colloidal compounds, and 300 parts of tampons.

[0043] The preparation method is as follows:

[0044] (1) After mixing the synthetic fatty acid ester and the colloidal compound at a weight ratio of 5:1, heat and melt in a water bath at 65°C to obtain a melt;

[0045] (2) Pour the molten matter described in step (1) into a plug mold, insert a sliver, cool and set the shape, and obtain a matrix plug core;

[0046] (3) After fully mixing the recombinant human interferon α1b and the traditional Chinese medicine composition, spray it on the surface of the matrix plug core described in step (2) in a spray form, and make a suppository after cooling dow...

Embodiment 2

[0049] In this embodiment, the vaginal expansion suppository includes, in parts by weight: 0.05 parts of recombinant human interferon α1b, 18 parts of comfrey extract, 5 parts of Viola extract, 8 parts of amethyst extract, 2 parts, polylactic acid 50 parts, mixture of synthetic fatty acid ester and natural fatty acid ester 80 parts and non-woven fabric 400 parts.

[0050] The preparation method is as follows:

[0051] (1) After mixing the synthetic fatty acid ester and the natural fatty acid ester at a weight ratio of 6:1, heat and melt in a water bath at 64°C to obtain a melt;

[0052] (2) Pour the molten matter described in step (1) into the plug mold, insert the non-woven fabric, cool and set the shape, and obtain the matrix plug core;

[0053] (3) After fully mixing the recombinant human interferon α1b and the traditional Chinese medicine composition, spray it on the surface of the matrix plug core described in step (2) in the form of a spray, and make a suppository after...

Embodiment 3

[0056] In this example, the vaginal expansion suppository includes, in parts by weight: 0.5 parts of recombinant human interferon α1b, 10 parts of comfrey extract, 9 parts of viola extract, 2 parts of amethyst extract, 8 parts, polycaprolactone 30 parts, synthetic fatty acid ester and lipid matrix mixture 150 parts and elastane 150 parts.

[0057] The preparation method is as follows:

[0058] (1) After mixing the synthetic fatty acid ester and the lipid base at a weight ratio of 2:1, place it in a water bath at 68° C. for heating and melting to obtain a melt;

[0059] (2) Pour the molten matter described in step (1) into a plug mold, insert elastic fibers, cool and set the shape, and obtain a matrix plug core;

[0060] (3) After fully mixing the recombinant human interferon α1b and the traditional Chinese medicine composition, spray it on the surface of the matrix plug core described in step (2) in a spray form, and make a suppository after cooling down to 37°C;

[0061] (4...

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Abstract

The invention provides a recombinant human interferon α1b vaginal expansion suppository and a preparation method thereof. The vaginal expansion suppository comprises, in parts by weight: 0.01-1.0 parts of recombinant human interferon α1b, 10-50 parts of a high molecular polymer, and a matrix 50‑200 parts and swelling carrier 100‑500 parts. The vaginal expansion suppository of the present invention uses recombinant human interferon α1b suitable for Chinese people as the main active ingredient, and has a remarkable curative effect, and its outer layer is coated with a high molecular polymer, which controls the release speed and action time of the active ingredient, reduces the The number of daily administration is reduced, so that the recombinant human interferon α1b can be better absorbed, distributed and metabolized by the human body, with less toxic and side effects.

Description

technical field [0001] The invention belongs to the field of vaginal suppositories, and relates to a vaginal expansion suppository and a preparation method thereof, in particular to a recombinant human interferon α1b vaginal expansion suppository and a preparation method thereof. Background technique [0002] Recombinant human interferon α1b is a kind of multifunctional and highly active inducible protein produced by white blood cells and lymphocytes of Chinese healthy people. It has significant broad-spectrum antiviral effect and immune regulation function. It has significant curative effect on vaginitis and has few side effects. , suitable for Chinese physique. At present, the dosage forms of recombinant human interferon α1b are mainly tablets and suppositories, but recombinant human interferon α1b is easy to decompose when exposed to light and moisture, and the development of new dosage forms is difficult, which seriously affects the wide application of recombinant human ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/21A61K9/02A61K47/34A61P15/02A61K36/86A61K33/14A61K35/50
Inventor 邱明世
Owner 哈尔滨田美药业股份有限公司
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