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Application of hederagenin and glucoside thereof in preparing anti-virus medicines

A hedera saponin and anti-virus technology, applied in the field of medicine, can solve the problems of hedera saponin and its glycosides that have not yet been seen

Active Publication Date: 2018-01-19
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report of helexin and its glycosides being used for antiviral

Method used

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  • Application of hederagenin and glucoside thereof in preparing anti-virus medicines
  • Application of hederagenin and glucoside thereof in preparing anti-virus medicines
  • Application of hederagenin and glucoside thereof in preparing anti-virus medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1: The pharmacological effect of hedera saponin and its glycoside

[0042] Anti-respiratory syncytial virus (RSV), herpes simplex virus type 1 (HSV-I) and coxsackie virus type B3 (CVB3) effect (references: Experimental study on the antiviral effect of Shufeng Jiedu Capsules in vivo, New Drugs and Clinical Pharmacology of Traditional Chinese Medicine, Volume 25, Issue 1, January 2014).

[0043]SPF grade ICR mice were randomly divided into 17 groups according to body weight and sex: normal control group, virus control group and hedera saponin or saponin administration group with sequence number 1-15. Except for the normal control group, each mouse in each group was infected with 0.5 mL of RSV at 10LD50, 0.3 mL of HSV-1 at 10LD50, and 0.5 mL of CVB3 at 10LD50 under light anesthesia. Drug intervention was performed 2 hours after nasal drops. The mice in the treatment group were given 30 mg / kg / d helexin or saponin by intragastric administration, and the normal c...

Embodiment 2

[0047] Embodiment 2: Preparation and pharmacological action of an extract containing helexin or its glycosides

[0048] Part 1: Preparation of Extract

[0049] Preparation method one 5kg of dry Lonicera chinense medicinal material, reflux extraction with 70% ethanol for 3 times, 2h each time, filter, combine the filtrate, reclaim the solvent under reduced pressure to obtain extractum (get partly dried to obtain total extract 1), add appropriate amount of water to suspend , filter, and load the sample on D101 macroporous resin, start gradient elution from 10%, 30%, 50%, 70%, 90% ethanol, and monitor whether the eluate contains Decaisoside E, Honeysuckle saponin B or Dipsacus saponin B, any of the three appear in the eluent and start to collect until all three are eluted from the resin and stop collecting. Concentrate and dry this part of the eluent to obtain the extract of Lonicera tomentosa Object 1.

[0050] Preparation method two 5kg of dry Lonicera chinensis medicinal ...

Embodiment 3

[0063] Embodiment 3: pharmaceutical preparation

[0064] 1. Tablet: 5g of helexin or saponin or Lonicera tomentosa extract of serial number 1-15, 50g of starch, 3g of magnesium stearate. Preparation process: take the hedera saponin or saponin or the extract of Lonicera tomentosa with the serial number 1-15, add starch and magnesium stearate, mix evenly, make granules, dry, and compress into tablets.

[0065] 2. Capsules: 5g of hedera saponin or saponin or Lonicera tomentosa extract with serial number 1-15, 50g of starch, 3g of magnesium stearate. Preparation process: take the hedera saponin or saponin or Lonicera tomentosa extract of serial number 1-15, add starch and magnesium stearate, mix evenly, make granules, dry, and pack into capsules.

[0066] 3. Injection: 1g of hedera saponin or saponin or Lonicera tomentosa extract with serial number 1-15, appropriate amount of sodium chloride for injection. Preparation process: take the hedera saponin or saponin or Lonicera chrys...

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Abstract

The invention discloses application of hederagenin and glucoside thereof in preparing anti-virus medicines, and provides application of No.1-15 hederagenin or saponin in preparing anti-virus medicines. Proofed by experiment results, the No.1-15 hederagenin or saponin has obvious protection function on RSV (respiratory syncytial virus), HSV-I (herpes virus-I) and CVB3 (coxsackie B3) virus-infectedmice; the death protection rate (%) of the No.1-15 hederagenin or saponin on the RSV, HSV-I and CVB3 virus-infected mice is 35% or above; the life elongation rate (%) of the No.1-15 hederagenin or saponin on the RSV, HSV-I and CVB3 virus-infected mice is 50% or above, so that the No.1-15 hederagenin or saponin can be developed into the antivirus medicines.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the new application of known natural products, in particular to the application of helexin and its glycosides in the preparation of antiviral drugs. Background technique [0002] Hederagenin is a pentacyclic triterpenoid compound with the chemical name (3β,4α)-3,23-dihydroxyolean-12-ene-28-acid, and the molecular formula is C 30 h 48 o 4 . Hedera saponin is a glycosidation product of hedera saponin. [0003] Hedera saponin and hedera saponin are abundant in natural resources, and are widely distributed in Disperaceae, Lonicaceae, Ranunculaceae, Araliaceae and Patrinaceae and other plants, and have good development advantages. The applicant has conducted systematic research on hederagenin and hedera saponin, and found that hedera saponin and hedera saponin have various pharmacological effects, have preventive value for various diseases, and have broad clinical development and application ...

Claims

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Application Information

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IPC IPC(8): A61K36/25A61K31/56A61K31/704A61P31/22A61P31/14
Inventor 齐炼文李萍
Owner CHINA PHARM UNIV
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