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Multifunctional nanocapsule integrating near infrared fluorescent imaging with chemotherapy/photothermal therapy

A technology of photothermal therapy and fluorescence imaging, which is applied in the field of biomedical materials, can solve the problems of cancer cells that are difficult to form compensatory resistance mechanisms, low drug load leakage, etc., and achieve the effect of increasing drug loading and improving curative effect

Active Publication Date: 2018-01-30
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The problem of drug resistance has been a long-term challenge in cancer treatment. In order to improve the therapeutic effect of clinical cancer treatment, the combination of drugs with different modes of action in precise control is used as a standard therapy in many kinds of cancer treatment, because it is the same as single or continuous Compared with the way of drug delivery, it is more difficult for cancer cells to form compensatory resistance mechanisms
However, their use in thermochemotherapy is often limited by low drug loading (typically less than 10%) and premature leakage
In particular, to the best of our knowledge, combination nanoparticles co-encapsulating DiR and two drugs have not been reported in the literature for combined imaging-guided chemotherapy and photothermal therapy therapy.

Method used

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  • Multifunctional nanocapsule integrating near infrared fluorescent imaging with chemotherapy/photothermal therapy
  • Multifunctional nanocapsule integrating near infrared fluorescent imaging with chemotherapy/photothermal therapy
  • Multifunctional nanocapsule integrating near infrared fluorescent imaging with chemotherapy/photothermal therapy

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Mix Janus drug copolymer, near-infrared dye DiR and distearoylphosphatidylethanolamine-polyethylene glycol 2000 (DSPE-PEG2000) according to a certain molar ratio (70%:10%:20%), and then use DMSO injection method , under the ultrasonic condition of a water bath at 50°C, inject the above mixture into deionized water; place the solution obtained above in a dialysis bag with a molecular weight cut-off of 8000-14000Da, dialyze for 2-4 hours, take it out and transfer it into a vial to obtain Multifunctional nanocapsules (CF-DiR NCs) integrating near-infrared fluorescence imaging and chemotherapy / photothermal therapy. Store in a sealed container at 4°C. The particle size distribution of nanocapsules is shown in the attached figure 2 shown.

Embodiment 2

[0027] Mix Janus drug copolymer, near-infrared dye DiR and distearoylphosphatidylethanolamine-polyethylene glycol 2000 (DSPE-PEG2000) according to a certain molar ratio (30%:50%:20%), and then use DMSO injection method , under the ultrasonic condition of a water bath at 50°C, inject the above mixture into deionized water; place the solution obtained above in a dialysis bag with a molecular weight cut-off of 8000-14000Da, dialyze for 2-4 hours, take it out and transfer it into a vial to obtain Multifunctional nanocapsules (CF-DiR NCs) integrating near-infrared fluorescence imaging and chemotherapy / photothermal therapy. Store in a sealed container at 4°C.

Embodiment 3

[0029]Mix Janus drug copolymer, near-infrared dye DiR and distearoylphosphatidylethanolamine-polyethylene glycol 5000 (DSPE-PEG5000) according to a certain molar ratio (70%:10%:20%), and then use DMSO injection method , under ultrasonic conditions in a water bath at 50°C, inject the above mixture into 0.8ml of water; place the solution obtained above in a dialysis bag with a molecular weight cut-off of 8000-14000Da, dialyze for 2 to 4 hours, take it out and transfer it to a vial to obtain Multifunctional nanocapsules (CF-DiR NCs) integrating near-infrared fluorescence imaging and chemotherapy / photothermal therapy. Store in a sealed container at 4°C.

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Abstract

The invention relates to a multifunctional nanocapsule integrating near infrared fluorescent imaging with chemotherapy / photothermal therapy and further relates to a preparation method of the multifunctional nanocapsule and application of the same in tumor diagnosis and treatment. A structural schematic diagram of the multifunctional nanocapsule is shown as in the figure, membrane components of themultifunctional nanocapsule include near infrared dye for photothermal therapy, amphipathic Janus drug copolymer for chemotherapy and conventional phospholipid, a proportion of a near infrared absorber to chemotherapy drug can be regulated according to needs, and drug loading capacity is greatly increased. The multifunctional nanocapsule can realize targeted gathering at a tumor position throughEPR effect, so that gathering and intake of drug at the tumor position are improved effectively, and effect on suppressing tumor growth through photothermal therapy and chemotherapy in a combined manner is improved remarkable.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and specifically relates to a class of multifunctional nanocapsules integrating near-infrared fluorescence imaging and chemotherapy / photothermal therapy, and its use in tumor diagnosis and treatment. Background technique [0002] The problem of drug resistance has been a long-term challenge in cancer treatment. In order to improve the therapeutic effect of clinical cancer treatment, the combination of precisely controlled drugs with different modes of action is used as a standard therapy in many cancer treatments, because it is the same as single or continuous Compared with the way of drug administration, it is more difficult for cancer cells to form compensatory resistance mechanisms. The simultaneous delivery of drug combinations and the control of release characteristics enabled by nanoparticles provide many unprecedented options for overcoming cancer drug resistance. It has now been demon...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/54A61K45/00A61K49/00A61K9/51A61P35/00
Inventor 戴志飞高闯梁晓龙
Owner PEKING UNIV
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