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Production method of fructus lycii, flos chrysanthemi and radix rehmanniae preparata pills

A production method and technology of Rehmannia glutinosa are applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., which can solve the problems of unsatisfactory clinical efficacy of Qiju Dihuang capsules, difficult to detect the active ingredients of Cortex Moutan, etc., and achieve the medicinal effect. Significant, easily measurable, high-level effects

Inactive Publication Date: 2018-02-02
贵州拜特制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the inventor found in the course of the research that the active ingredients of Moutan cortex, especially paeonol, are not easy to detect in the Qiju Dihuang capsules made by the existing extraction process, which makes the clinical curative effect of Qiju Dihuang capsules not ideal enough.

Method used

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  • Production method of fructus lycii, flos chrysanthemi and radix rehmanniae preparata pills
  • Production method of fructus lycii, flos chrysanthemi and radix rehmanniae preparata pills
  • Production method of fructus lycii, flos chrysanthemi and radix rehmanniae preparata pills

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Effect test

Embodiment 1

[0093] Formula: 36.7g medlar, 36.7g chrysanthemum, 146.8g Rehmannia glutinosa, 73.4g wine cornus, 55g moutan cortex, 73.4g yam, 55g poria cocos and 55g salt Alisma.

[0094] Process:

[0095] (1) Add 12 times the amount of water to decoct Moutan cortex for 3 times, each time for 2 hours, combine the decoction, filter, concentrate until the ratio of volume per milliliter to medicinal material per gram is 1.5:3, filter, add ethanol to the supernatant , so that the alcohol content reaches 75%, adjust the pH to 7-10 with 12% sodium hydroxide solution, refrigerate, filter, recover ethanol, add water until the ratio of volume per milliliter to medicinal material per gram is 1.5:3, adjust with 12% hydrochloric acid solution pH 5-7, filtered, concentrated to the extract with a relative density of 1.10-1.20 at 50-60°C, vacuum-dried, crushed into fine powder, dried peony bark paste powder, set aside;

[0096] (2) Chinese yam was decocted 3 times with 10 times of water, 2 hours each tim...

Embodiment 2

[0102] Formula: 36.7g medlar, 36.7g chrysanthemum, 146.8g Rehmannia glutinosa, 73.4g wine cornus, 55g moutan cortex, 73.4g yam, 55g poria cocos and 55g salt Alisma.

[0103] Process:

[0104] (1) Add 12 times the amount of water to decoct Moutan cortex for 3 times, each time for 2 hours, combine the decoction, filter, concentrate until the ratio of volume per milliliter to medicinal material per gram is 1.5:3, filter, add ethanol to the supernatant , so that the alcohol content reaches 75%, adjust the pH to 7-10 with 12% sodium hydroxide solution, refrigerate, filter, recover ethanol, add water until the ratio of volume per milliliter to medicinal material per gram is 1.5:3, adjust with 12% hydrochloric acid solution pH 5-7, filtered, concentrated to the extract with a relative density of 1.10-1.20 at 50-60°C, vacuum-dried, crushed into fine powder, dried peony bark paste powder, set aside;

[0105] (2) Chinese yam was decocted 3 times with 10 times of water, 2 hours each tim...

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Abstract

The invention discloses a production method of fructus lycii, flos chrysanthemi and radix rehmanniae preparata pills. According to properties of all medicines in a fructus lycii, flos chrysanthemi andradix rehmanniae preparata prescription and effects of the medicines in the prescription, a specific production technology and parameters of the fructus lycii, flos chrysanthemi and radix rehmanniaepreparata pills are improved, so that an effective component paeonol of cortex moutan is easily determined and the content of the determined paeonol is high. The medicine is more refined and has a more remarkable medicinal effect and a good clinical curative effect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a preparation method of Qiju Dihuang preparation. Background technique [0002] Extraction of traditional Chinese medicine is a commonly used method in traditional Chinese medicine pharmacy. The chemical composition of traditional Chinese medicine is extremely complex, and it is necessary to extract the active ingredients of traditional Chinese medicine that are effective for the human body from the complex mixture. to improve efficacy. [0003] Qiju Dihuang Capsules are mainly made of 36.7g medlar, 36.7g chrysanthemum, 146.8g Rehmannia glutinosa, 73.4g wine cornus, 55g moutan cortex, 73.4g yam, 55g poria cocos and 55g salt Alisma. [0004] In the prior art, the Qiju Dihuang Capsules are made in the following way: the above eight flavors, the above peony cortex, Chinese yam, Poria cocos, and Alisma alisma are pulverized into fine powder; Chinese wolfberry...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K9/48A61P43/00
CPCA61K9/48A61K36/076A61K36/287A61K36/40A61K36/65A61K36/71A61K36/804A61K36/815A61K36/884A61K36/8945A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 薛捷先德清张程益何容杨丹刘飞
Owner 贵州拜特制药有限公司
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