Liposome gel for operational prognosis scar hypertrophy and preparation method of liposome gel

A technology of liposome gel and scar hyperplasia, which is applied in the field of medical care and can solve the problems of hypertrophic scar repair and reconstruction and difficult burn treatment

Inactive Publication Date: 2018-02-09
芮志行
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Technical problem to be solved by the present invention: Aiming at the difficult problem of hypertrophic scar repair and reconstruction and burn treatment, the present invention provides a liposome gel for postoperative scar hyperplasia and its preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0022] Take 20g comfrey, 10g myrrh, 10g frankincense, 10g chuanxiong, 10g angelica, 10g safflower, 10g bone grass, 10g raw chuanwu, 10g Fangfeng, 10g pepper, 10g borneol, 10g sodium chloride, 10g sodium sulfate, Add 5g of magnesium sulfate, 5g of calcium sulfate, and 5g of artesunate into 1L of deionized water, heat to 95°C and cook for 1 hour, filter to obtain the filtrate and filter residue, repeat the cooking of the filter residue once and then filter, combine the filtrate and evaporate to concentrate to the original solution The volume is 20% to obtain a Chinese medicine prescription solution. Take 1g lecithin, 1g cholesterol, and 1g octadecylamine, add it to 30g absolute ethanol, stir at 300r / min for 10min, then add 10g Chinese medicine prescription solution, heat to 50°C, and heat at 300W Ultrasonic ultrasonic dispersion for 20 minutes to obtain a dispersion liquid, add 3 g of carbomer-940 and 3 g of propylene glycol to the dispersion liquid, stir at 300 r / min for 30 min,...

example 2

[0024] Take 25g comfrey, 12g myrrh, 12g frankincense, 12g chuanxiong, 12g angelica, 12g safflower, 12g bone grass, 12g raw chuanwu, 12g Fangfeng, 12g pepper, 12g borneol, 12g sodium chloride, 12g sodium sulfate, Add 8g of magnesium sulfate, 8g of calcium sulfate, and 8g of artesunate into 1L of deionized water, heat to 98°C and cook for 1 hour, filter to obtain the filtrate and filter residue, repeat the cooking of the filter residue twice and then filter, combine the filtrate and evaporate to concentrate to the original solution The volume is 25% to obtain a Chinese medicine prescription liquid. Take 1g lecithin, 1g cholesterol, and 1g octadecylamine, add it to 40g absolute ethanol, stir at 350r / min for 15min, then add 15g Chinese medicine prescription liquid, heat to 55°C, and heat at 300W Ultrasonic dispersion was performed for 25 minutes to obtain a dispersion. Add 4 g of Carbomer-940 and 4 g of propylene glycol to the dispersion, stir at 350 r / min for 35 minutes, and then ...

example 3

[0026] Take 30g comfrey, 15g myrrh, 15g frankincense, 15g chuanxiong, 15g angelica, 15g safflower, 15g bone grass, 15g raw chuanwu, 15g Fangfeng, 15g pepper, 15g borneol, 15g sodium chloride, 15g sodium sulfate, Add 10g of magnesium sulfate, 10g of calcium sulfate, and 10g of artesunate into 2L of deionized water, heat to 100°C and cook for 2 hours, filter to obtain the filtrate and filter residue, repeat the cooking of the filter residue for 3 times and then filter, combine the filtrate and evaporate to concentrate to the original solution The volume is 30% to obtain a traditional Chinese medicine prescription solution. Take 2g lecithin, 2g cholesterol, and 2g octadecylamine, add them to 50g absolute ethanol, stir at 400r / min for 20min, then add 20g traditional Chinese medicine prescription solution, heat to 60°C, and heat at 300W Ultrasonic dispersion was performed for 30 minutes to obtain a dispersion. Add 5 g of Carbomer-940 and 5 g of propylene glycol to the dispersion, st...

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PUM

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Abstract

The invention relates to liposome gel for operational prognosis scar hypertrophy and a preparation method of the liposome gel and belongs to the technical field of medical care. By utilizing lithospermum with effects of cooling blood and dissipating blood stasis, moistening skin and relieving pain, improving skin blood circulation and promoting transdermal absorption, taking myrrh, frankincense and ligusticum wallichii as auxiliary materials, angelica sinensis and safflower are used for dispelling cold, activating blood and relieving pain, garden balsam stem, radix aconiti kusenzoffii, divaricate saposhnikovia root and Sichuan pepper achieve effects of eliminating wind-cold damp pathogen stagnated in main and collateral channels and relieving pain, borneol has the effect of moistening andprotecting skin, and mineral substances with excellent effects of diminishing inflammation, reducing swelling and permeating are mixed so as to cooperatively accelerate collagen degradation and inhibiting artesunate deposited on an extracellular matrix. The components are prepared into the liposome gel to achieve the effects of promoting protein coagulation in blood and cells, blocking coagulation, wilt and defulvium of lesions caused by abnormal pathways at lesion locations and improving local blood circulation and peripheral termination of nerves. The liposome gel achieves the effects of relieving itching, diminishing inflammation and relieving pain and is capable of inhibiting scar proliferation.

Description

technical field [0001] The invention relates to a liposome gel for postoperative scar hyperplasia and a preparation method thereof, belonging to the technical field of medical care. Background technique [0002] Skin hypertrophic scars (hypertrophicscars, HS) is one of the common clinical diseases, often can affect the appearance and function of patients to varying degrees, and difficult to deal with. Scar tissue is a natural product in the process of human trauma repair. The damage that reaches deep into the dermis and subcutaneous tissue needs to be repaired through scars. However, the mechanical resistance of hypertrophic scars and keloids is weakened, forming a barrier for the exchange of oxygen and nutrients. Often due to contraction and stretching, deformity and dysfunction of damaged tissues are caused, so surgery is often required. Any type of biological, chemical or physical injury will induce a cascade of humoral-cellular responses in vivo, resulting in a fibropro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K9/127A61K47/32A61K47/28A61K36/758A61P17/02A61K33/14A61K33/06A61K33/04A61K31/357A61K31/045
CPCA61K9/0014A61K9/06A61K9/127A61K31/045A61K31/357A61K33/04A61K33/06A61K33/14A61K36/185A61K36/232A61K36/236A61K36/238A61K36/286A61K36/30A61K36/324A61K36/328A61K36/47A61K36/714A61K36/758A61K47/28A61K47/32A61K2236/331A61K2300/00
Inventor 芮志行王之霖
Owner 芮志行
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