Aerosol for treating diseases of respiratory system and preparation method of aerosol

A respiratory disease and aerosol technology, which is applied in the field of aerosols for the treatment of respiratory diseases and its preparation, can solve problems such as undeveloped dosage forms, and achieves the effects of treating respiratory diseases with stable quality and remarkable effect.

Inactive Publication Date: 2018-02-09
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In the prior art, although there has been research on the combined use of ambroxol hydrochloride, budesonide and ribavirin, it has not been developed into a specific and feasible dosage form

Method used

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  • Aerosol for treating diseases of respiratory system and preparation method of aerosol
  • Aerosol for treating diseases of respiratory system and preparation method of aerosol
  • Aerosol for treating diseases of respiratory system and preparation method of aerosol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Weigh each component according to the following weight ratio: Ambroxol hydrochloride 30g, budesonide 20g, ribavirin 20g, glycerin 100g, sorbitan trioleate 15g, PVP 15g, sorbic acid 0.5g, peppermint essence 0.5g , crush ambroxol hydrochloride, budesonide and ribavirin through a 200-mesh sieve, add purified water and stir to dissolve evenly, add glycerin, sorbitan trioleate, PVP, sorbic acid and sodium saccharin, and use a high-pressure homogenizer Stir homogeneously, then add mint essence, continue to stir evenly, fill with valves, fill with propellant dichlorodifluoroethane, check for leaks and weigh, install a booster, and the product is ready.

Embodiment 2

[0019] Each component was weighed according to the following weight ratio: 50g of ambroxol hydrochloride, 40g of budesonide, 30g of ribavirin, 200g of glycerin, 25g of sorbitan trioleate, 25g of PVP, 1g of sorbic acid, 2g of peppermint essence, and Ambroxol hydrochloride, budesonide and ribavirin were crushed through a 200-mesh sieve, added to purified water, stirred and dissolved evenly, added glycerin, sorbitan trioleate, PVP, sorbic acid and sodium saccharin, and homogenized with a high-pressure homogenizer Stir, then add peppermint essence, continue to stir evenly, fill with valves, fill with propellant dichlorodifluoroethane, check for leaks and weigh, install a booster, and you have it.

Embodiment 3

[0021] Weigh each component according to the following weight ratio: 40g of ambroxol hydrochloride, 30g of budesonide, 25g of ribavirin, 150g of glycerin, 20g of sorbitan trioleate, 20g of PVP, 1g of sorbic acid, 1g of peppermint essence, and Ambroxol hydrochloride and albuterol sulfate were crushed through a 200-mesh sieve, added to purified water, stirred and dissolved evenly, and then ethanol, propylene glycol, sodium laurylsulfonate, PVP, vitamin C and methyl p-hydroxybenzoate were added, and high-shear Stir homogeneously for about 30 minutes under the mixer, add apple essence, continue stirring for about 20 minutes, fill with valves, fill with propellant F12, check for leaks and weigh, install a booster, and the product is ready.

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PUM

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Abstract

The invention relates to an aerosol for treating diseases of respiratory system and a preparation method of the aerosol, and belongs to the field of pharmaceutical preparations. The aerosol is prepared from the following components: 30-50g of ambroxol hydrochloride, 20-40g of budesonide, 20-30g of ribavirin, 100-200g of glycerol, 15-25g of sorbitan trioleate, 15-25g of PVP, 0.5-1g of sorbic acid,0.5-2g of peppermint essence, a proper amount of saccharin sodium, a proper amount of dichlorodifluoroethane and a proper amount of purified water. The aerosol provided by the invention is stable in quality, obvious in effect and is capable of effectively treating the diseases of respiratory system.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an aerosol for treating respiratory diseases and a preparation method thereof. Background technique [0002] Respiratory system disease is a kind of common disease, and it includes cold, tracheitis, pneumonia etc., can come on in all seasons of the year, especially in winter and spring. The reason why respiratory system diseases are common diseases is related to the anatomical parts and physiological functions of the respiratory system. [0003] What we usually call the respiratory system consists of the nose, pharynx, larynx, trachea, bronchi and alveoli at all levels. Nasal mucous membrane secretes fluid, which moistens the inhaled air and wraps inhaled foreign matter, which is expelled through coughing or nasal mucus. The nasal hairs in the nasal cavity, nasopharynx and nasal vestibule can block the passage of dust and foreign objects. The throat, such as the tons...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K9/72A61K47/32A61K47/10A61K47/26A61K47/12A61K31/7056A61K31/137A61K31/58A61P11/00
CPCA61K9/008A61K31/137A61K31/58A61K31/7056A61K47/10A61K47/12A61K47/26A61K47/32A61K2300/00
Inventor 韩萍王维张作进李冉张华黄鹏
Owner QINGDAO UNIV
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