Synthetic method for anti-HIV active sulfonic acid based bagasse xylan p-ferrocene benzoate

Abstract

The invention discloses a preparation method for anti-HIV active sulfonic acid based bagasse xylan p-ferrocene benzoate. The preparation method comprises the following steps: with bagasse xylan as a raw material, sodium trisulphamidate as an esterifying agent of a reaction in a first step, and p-toluene sulphonic acid as a catalyst, carrying out an esterification reaction and hydrochloric acidizing treatment in an aqueous phase so as to obtain sulfonic acid based bagasse xylan, and determining the substitution degree of sulfation; and on the basis of synthesizing the sulfonic acid based bagasse xylan, and with p-ferrocene based benzoic acid as the carboxylating agent in a second step and phosphomolybdic acid as a catalyst, and carrying out an esterification reaction with the sulfonic acidbased bagasse xylan in a chloroform solvent so as to synthesize the sulfonic acid based bagasse xylan p-ferrocene benzoate. The preparation method has the following advantages: the sulfonic acid basedbagasse xylan p-ferrocene benzoate obtained by using the method provided by the invention has the biological activity of bagasse xylan sulfate; meanwhile, the anti-biological activity of p-ferrocenebenzoic acid is introduced; characteristics like high raw material utilization rate and stable product quality are obtained; and important application values in fields like biology, medicine and functional materials are realized.

Description

technical field [0001] The invention belongs to the technical field of fine chemicals, and in particular relates to a method for synthesizing anti-HIV active sulfonated bagasse xylan p-ferrocene benzoate. Background technique [0002] Converting a large amount of biomass resources in agriculture into biomass-based energy and functional materials has become an important research topic and social development trend that researchers at home and abroad pay attention to. In order to more effectively utilize agricultural and forestry biomass resources and promote the high-value conversion of hemicelluloses such as xylan, it is of great significance to chemically modify natural polysaccharides such as xylan. [0003] Studies have shown that sulfoxylan has anti-HIV activity, but the anti-HIV activity produced by a single active group in the monoesterified derivative is limited. If the monoesterified derivative is further modified to introduce other anti-biological active groups grou...

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Problems solved by technology

[0003] Studies have shown that sulfoxylan has anti-HIV activity, but the anti-HIV activity produced by a single active group in the monoesterified derivative is limited. If further modification on the basis of the monoesterified derivative introduces other anti-biological active groups group, will significantly improve the anti-HIV activity of xylan esterified derivatives

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