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Medicinal preparation and preparation method and application thereof

A technology for pharmaceutical preparations and medicines, applied in the field of pharmaceutical preparations and preparations thereof, can solve the problems of reducing the decomposition degree of the active ingredients of benzoyl peroxide and clindamycin phosphate, and achieves the maintenance of efficacy, a short production cycle, and reduced The effect of the degree of decomposition

Inactive Publication Date: 2018-02-27
SHANGHAI MEDICILON INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The first object of the present invention is to provide a kind of pharmaceutical preparation, described pharmaceutical preparation is prepared by selecting benzoyl peroxide with a specific particle size distribution, and when it is prepared into a mixed preparation with clindamycin phosphate, it can fully improve the obtained The stability of the pharmaceutical preparation greatly reduces the degree of decomposition of the two active ingredients of benzoyl peroxide and clindamycin phosphate, and effectively overcomes the two effective components of benzoyl peroxide and clindamycin phosphate in the related art. Poor stability of ingredient formulations during long-term storage

Method used

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  • Medicinal preparation and preparation method and application thereof
  • Medicinal preparation and preparation method and application thereof

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preparation example Construction

[0077] The above-mentioned preparation method of a pharmaceutical preparation comprises fully uniformly mixing and dispersing raw materials to obtain a pharmaceutical preparation.

[0078] Optionally, the preparation method of the pharmaceutical preparation comprises:

[0079] a. Uniformly dispersing benzoyl peroxide into a solvent containing clindamycin phosphate, matrix, humectant, stabilizer, preservative, and co-emulsifier, fully mixing and dispersing evenly, to obtain a mixed solution;

[0080] The benzoyl peroxide is processed to obtain the required particle size distribution;

[0081] b. Add lubricant and emulsifier to the resulting mixed solution, fully mix and disperse evenly;

[0082] c. adjusting the pH with a pH adjusting agent to obtain a pharmaceutical preparation.

[0083] The preparation method of the pharmaceutical preparation of the invention has the advantages of simple process, convenient operation and short production cycle, and is suitable for industria...

Embodiment 1

[0090]

[0091]

[0092] A preparation method of a pharmaceutical preparation, comprising:

[0093] 1) Matrix formation: the matrix mainly includes carbomer, caprylic capric acid macrogolglyceride, EDTA, ethyl p-hydroxybenzoate, clindamycin phosphate;

[0094] 2) Addition of benzoyl peroxide: add benzoyl peroxide to the swollen matrix, and fully grind it with a colloid mill until the qualified particle size is reached;

[0095] 3) Addition of humectants, emulsifiers, and lubricants: mainly polyglycerol oleate, glycerin, simethicone, and silicon dioxide, and adjust the pH in this link to obtain the product.

Embodiment 2

[0097]

[0098]

[0099] A preparation method of a pharmaceutical preparation, comprising:

[0100] 1) Preparation of benzoyl peroxide solution: add benzoyl peroxide to an appropriate amount of water, and process it in a colloid mill for 2.5 hours;

[0101] 2) Matrix formation: add carbomer, caprylic capric acid macrogolglyceride, EDTA, and ethyl p-hydroxybenzoate to the benzoyl peroxide solution, and mix well;

[0102] 3) Addition of humectants, emulsifiers and lubricants: mainly polyglycerol oleate, glycerin, simethicone, silicon dioxide, and adjust the pH in this link;

[0103] 4) Addition of Clindamycin Phosphate: Dissolve Clindamycin Phosphate in an appropriate amount of water, add it to the above matrix, and stir thoroughly to obtain the product.

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Abstract

The invention relates to the field of medicaments, and particularly relates to a medicinal preparation and a preparation method and application thereof. The medicinal preparation is prepared from benzoyl peroxide with specific particle size distribution, and when the medicinal preparation is prepared into a mixed preparation together with clindamycin phosphate, the stability of the medicinal preparation can be sufficiently improved, the decomposing degree of two effective components, namely, benzoyl peroxide and clindamycin phosphate, is greatly reduced, and the problem of poor stability of apreparation with the two effective components, namely, benzoyl peroxide and clindamycin phosphate, in long-term storage is solved. The preparation method of the medicinal preparation is simple in process, convenient in operation, short in production cycle, and suitable for large-scale industrialized production. The medicinal preparation disclosed by the invention is applicable to preparation of external medicaments, preferably applicable to preparation of a medicine for treating acne, can effectively inhibit the decomposition of two effective components, namely benzoyl peroxide and clindamycinphosphate, can be stably stored for a long time and can keep efficacy for a long time.

Description

technical field [0001] The present invention relates to the field of pharmaceuticals, in particular to a pharmaceutical preparation and its preparation method and application. Background technique [0002] Acne is a chronic inflammatory skin disease of the sebaceous glands, with an incidence rate of 70% to 87%, mostly occurring in adolescence, and has a serious impact on the psychology and social interaction of adolescents. The occurrence of acne is mainly closely related to many factors such as excessive sebum secretion, pilosebaceous gland duct blockage, bacterial infection and inflammatory response. There are many kinds of microorganisms in hair follicles, such as Propionibacterium acnes, Staphylococcus albus and Malassezia, among which Propionibacterium acnes infection is the most important. Propionibacterium acnes is an anaerobic bacterium, and the obstruction of sebum discharge just creates a good local anaerobic environment for it, which makes Propionibacterium acnes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7056A61K31/327A61P17/10
CPCA61K9/0014A61K31/327A61K31/7056A61K2300/00
Inventor 陈春麟陈香程萍李国栋孙珏
Owner SHANGHAI MEDICILON INC
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