Synthesis of 9-chloro-1,2,3,4-tetrahydroacridine-platinum (II) complex targeted to liver cancer and application of the complex
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- YULIN NORMAL UNIVERSITY
- Publication Date
- 2018-03-02
Smart Images
Figure 1 
Figure 2 
Figure 3
Abstract
Description
technical field
[0001] The invention relates to the technical field of medicine, in particular to the synthesis and application of a 9-chloro-1,2,3,4-tetrahydroacridine-platinum (II) complex targeting liver cancer. Background technique
[0002] Since the 1970s, cisplatin has been widely used clinically to treat various malignant tumors such as testicular cancer, cervical cancer, bladder cancer, ovarian cancer, head and neck cancer, and small cell or non-small cell lung cancer. One of the most effective and commonly used drugs for tumors (Rosenberg, B.; et al. Nature, 1965, 205:698-699.), but serious adverse reactions in normal tissues often limit its clinical application, and the adverse reactions of cisplatin have Ototoxicity, gastrointestinal toxicity, myelosuppression, allergy and nephrotoxicity (Liang H.; et al. Eur. J. Med. Chem., 2015, 92:302-313.). Therefore, it is imminent to develop new platinum-based anti-tumor chemotherapy drugs with high efficiency, low toxicity...