Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation technology of controlled-release type gastric floating tablet for preventing and treating ruminant endoparasite

An endoparasite and ruminant technology, which is applied in the field of preparation of slow-release gastric floating tablets for ruminant endoparasite prevention and control, can solve the problems of easy generation of drug resistance, low drug availability, long drug taking time, etc. The effect of bioavailability, stabilizing blood concentration, and reducing the frequency of medication

Inactive Publication Date: 2018-03-06
马多浩
View PDF1 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although chemical drugs have a quick effect, they are prone to relapse after treatment, and they are prone to drug resistance and side effects. Although traditional Chinese medicine is safe to use, it has a slow onset of action, takes a long time to take the drug, and has low drug utilization.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation technology of controlled-release type gastric floating tablet for preventing and treating ruminant endoparasite
  • Preparation technology of controlled-release type gastric floating tablet for preventing and treating ruminant endoparasite
  • Preparation technology of controlled-release type gastric floating tablet for preventing and treating ruminant endoparasite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1) Preparation of composite carrier: Add dropwise 40-45°C deionized water to 15g food grade polyglutamic acid under stirring until completely dissolved, and add dropwise 5wt% dilute sulfuric acid to adjust the pH value of the solution to be stable at 3 within 10min. -4, add 10g poloxamer 188 and 5g polyethylene glycol 4000, add 40-45 ℃ deionized water under stirring to completely dissolve poloxamer and polyethylene glycol 4000, and heat up to reflux state to keep warm Stir for 3 hours, then cool down to 0-5°C at a cooling rate of 5°C / min and keep stirring for 30 minutes. The resulting mixture is sent to a freeze dryer, and the dried solid is made into a fine powder by an ultrafine pulverizer to obtain a composite carrier;

[0040] (2) Modification of the composite carrier: Add 2 g of food-grade sodium polyacrylate and 1 g of hydrogenated palm oil to the prepared 15 g of the composite carrier, mix well and use a microwave processor to treat with microwaves for 5 minutes,...

Embodiment 2

[0044] (1) Preparation of composite carrier: Add dropwise 40-45° C. deionized water to 10 g of food-grade polyglutamic acid under stirring until completely dissolved, and add dropwise 5 wt % dilute sulfuric acid to adjust the pH value of the solution to be stable at 3 within 10 min. -4, add 5g Poloxamer 407 and 3g Polyethylene Glycol 4000, add 40-45°C deionized water under stirring to completely dissolve Poloxamer and Polyethylene Glycol 4000, and heat up to reflux state to keep warm Stir for 3 hours, then cool down to 0-5°C at a cooling rate of 5°C / min and keep stirring for 30 minutes. The resulting mixture is sent to a freeze dryer, and the dried solid is made into a fine powder by an ultrafine pulverizer to obtain a composite carrier;

[0045] (2) Modification of the composite carrier: Add 3 g of food-grade sodium polyacrylate and 2 g of hydrogenated palm oil to the prepared 20 g of the composite carrier, mix well and use a microwave processor to treat with microwaves for 5 ...

Embodiment 3

[0049] (1) Preparation of composite carrier: Add dropwise 40-45° C. deionized water to 10 g of food-grade polyglutamic acid under stirring until completely dissolved, and add dropwise 5 wt % dilute sulfuric acid to adjust the pH value of the solution to be stable at 3 within 10 min. -4, add 5g Poloxamer 407 and 3g Polyethylene Glycol 4000, add 40-45°C deionized water under stirring to completely dissolve Poloxamer and Polyethylene Glycol 4000, and heat up to reflux state to keep warm Stir for 3 hours, then cool down to 0-5°C at a cooling rate of 5°C / min and keep stirring for 30 minutes. The resulting mixture is sent to a freeze dryer, and the dried solid is made into a fine powder by an ultrafine pulverizer to obtain a composite carrier;

[0050] (2) Modification of the composite carrier: Add 3 g of food-grade sodium polyacrylate and 2 g of hydrogenated palm oil to the prepared 20 g of the composite carrier, mix well and use a microwave processor to treat with microwaves for 5 ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation process of a slow-release gastric floating tablet for the prevention and treatment of endoparasites in ruminants, and relates to the technical field of gastric floating preparations, comprising the following steps: (1) preparation of a composite carrier, (2) modification of the composite carrier , (3) Preparation of gastric floating tablets. The slow-release gastric floating tablet prepared by the invention is suitable for the prevention and control of endoparasites in ruminants, is non-toxic and harmless, and has no potential safety hazard; it is in a floating state after entering the gastric juice of ruminants, and the contained endoparasite control agent is slowly released, Effectively prolong the residence time of the endoparasite control agent in the stomach, thereby prolonging the release time of the drug effect molecule, improving the bioavailability of the drug effect molecule, thereby ensuring the control effect on the endoparasites of ruminants and reducing the number of drugs.

Description

Technical field: [0001] The invention relates to the technical field of gastric flotation preparations, in particular to a preparation process of a slow-release gastric flotation tablet for the prevention and treatment of internal parasites in ruminants. Background technique: [0002] Ruminants are a suborder of Artiodactyla. Rumination refers to returning the half-digested food in the stomach to the mouth for chewing again after a period of time after eating. Ruminants are animals that have the digestion method of rumination. Usually some herbivores, because plant fiber is relatively difficult to digest. Ruminants generally eat in a hurry, especially roughage, most of which are swallowed into the rumen without being fully chewed. After being soaked and softened in the rumen for a period of time, the food is regurgitated and returned to the mouth. The process of swallowing into the rumen. [0003] Ruminants will encounter many parasitic pathogens during their growth proce...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/22A61K47/34A61K47/10A61K36/9064A61P33/00
CPCA61K9/0065A61K9/2031A61K9/2045A61K36/185A61K36/28A61K36/30A61K36/482A61K36/489A61K36/532A61K36/535A61K36/67A61K36/73A61K36/899A61K36/9064A61K2236/33A61K2236/331A61K2300/00
Inventor 马多浩
Owner 马多浩
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com