Method for Biologically Storing and Restoring Data

Abstract

The present invention relates to a method and a device for converting data into a data DNA sequence with good biological implantability, and restoring the DNA sequence library to original data, and also relates to a software product for realizing the method and storing the software product computer readable storage media. The invention realizes the possibility of storing data in organisms by constructing a data DNA library.

Description

technical field [0001] The invention belongs to the fields of bioinformatics, synthetic biology and computers, and in particular relates to a conversion method capable of converting data into biologically adaptable DNA sequences and restoring the DNA sequence library to original data. Background technique [0002] The 21st century is the century of life sciences, as well as the century of information and big data. At present, with the vigorous development of information technology, an important issue associated with it is how to deal with increasingly huge data. According to the information provided by International Data Corporation, the total amount of information data generated in the world has reached about 0.8ZB (1ZB=1.18*1021B) in 2009. At the same time, the organization also predicts that by 2020, the total amount of global data will reach 40ZB. Existing data storage technology exposes its shortcomings of low storage density, high storage energy consumption, and shor...

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Problems solved by technology

First of all, the binary algorithm adopted by Church et al. has a lot of room for improvement in information storage density, and the problem of high mutation rate introduced by the continuous repetition of single bases has not been solved; secondly, although Professor Goldman’s team applied ternary The algorithm improves the above two problems at the same time, but the information storage density of 2.2PB / gram of single-stranded DNA obtained by them is still far from the theoretical value of 445EB / gram of single-stranded DNA. Due to the limitation of the ternary conversion rule itself, on the other hand, due to the quadruple redundancy error correction mechanism, the sequence length is increased to 4 times the original sequence, and the conversion efficiency is reduced to a quarter. Accordingly, DNA synthesis and The cost of sequencing will also increase by 4 times at the same time; moreover, both Church and Goldman and others have only solved the problem of storing data through DNA under the premise of preserving DNA in vitro, and the biological adaptability required for implanting data DNA into organisms and error correction mechanism, they failed to give a good solution; finally, David Haughton and others from the computer field combined the "quaternary" algorithm and channel coding technology to significantly improve the information storage density and A near-optimal solution that satisfies the biological adaptability and error correction mechanism is given, but there are also problems, such as the 1 or 2 bits at the end of the 0 / 1 binary sequence that cannot be correctly encoded in the "quaternary" algorithm problems, as well as the problem of preventing the occurrence of start codons during the generation and integration of position information sequences, and David Haughton et al. only gave a set of solutions for how to convert data into data DNA sequences, and the complete process of biological storage No solution given, no actual tried and tested

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