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Chloromethyl isopropyl carbonate continuous reaction device and method

A chloromethyl isopropyl carbonate, chemical reaction technology, applied in the field of chloromethyl isopropyl carbonate continuous reaction device, can solve the problems of waste water, consumption and the like

Pending Publication Date: 2018-03-16
INNER MONGOLIA SAINTCHEM CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This process will bring additional raw material consumption due to the use of acid-binding agents, including acid-binding agents and alkalis for recycling acid-binding agents, and often produces waste water, which brings corresponding environmental problems

Method used

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  • Chloromethyl isopropyl carbonate continuous reaction device and method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1, in the rectifying tower of the combination of 3 sets of 2000L reactors connected in series and a DN800*16000 meter high tower, drop into chloromethyl chloroformate 260.08kg / h per hour, Virahol 174.41kg / h h, the temperature of the three-stage reactor is controlled at 40 degrees, the temperature at the bottom of the rectification tower is controlled at 80 degrees, the temperature at the top of the tower is controlled at -20 degrees, the vacuum degree of the system is -0.07MPa, and the quality of the final crude product is 366.76kg / h. The remaining unreacted S05 is 63.70 kg / h, and the mass of hydrogen chloride gas pumped out from the vacuum pump is 66.54 kg / h, with a content of about 99%.

Embodiment 2

[0019] Embodiment 2, in the reactor of 3 2000L reactors connected in series and a DN800*16000 meter high tower combination, drop into chloromethyl chloroformate 195.06kg / h per hour, Virahol 130.80kg / h , the temperature of the three-stage reactor is controlled at 40 degrees, the temperature at the bottom of the deacidification tower is controlled at 80 degrees, the temperature at the top of the tower is controlled at -20 degrees, and the vacuum degree of the system is -0.07MPa. The quality of the final crude product is 274.03kg / h. The remaining S05 of the reaction is 47.02kg / h, and the mass of hydrogen chloride gas pumped out from the vacuum pump is 49.21 kg / h, with a content of about 99%.

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Abstract

The invention relates to a chloromethyl isopropyl carbonate continuous reaction device and method, in particular to a continuous reaction device consisting of a multi-stage continuous stir reactor capable of generating reaction between chloromethyl chloroformate and isopropanol to generate chloromethyl isopropyl carbonate, and a continuous reaction rectifying tower. The reaction device has the characteristics that firstly, the chloromethyl chloroformate and the isopropanol are continuously mixed in a storage tank, then the mixture enters multiple stages of serially connected reaction kettles,hydrogen chloride is sucked away during reaction, and materials are pumped into the rectifying tower after the reaction in the multiple stages of reaction kettles is completed; the hydrogen chloride is completely cleared away through heating of a reboiler; after the reaction in the tower is balanced, the product is put into a rectifying device, thus obtaining a finished product. The hydrogen chloride gas at the top of the tower is condensed to remove isopropanol, and then enters a vacuum pump; after removal in the vacuum pump is completed, the gas enters a hydrogen chloride absorption workingsection, thus obtaining hydrochloric acid.

Description

technical field [0001] The invention relates to a continuous reaction device and method for chloromethyl isopropyl carbonate. Background technique [0002] Chloromethyl isopropyl carbonate, Chloromethyl isopropyl carbonate, molecular formula C5H9ClO3, CAS NO: 35180-01-9, density: 1.15g / cm³, boiling point: 147.463°C, used as organic synthesis intermediate, anti-AIDS and hepatitis B drug substitute Novovir / tenofovir intermediates. [0003] The traditional process of chloromethyl isopropyl carbonate takes the route of reacting chloromethyl chloroformate and isopropanol in the presence of an acid-binding agent, and the reaction generates the salt of the acid-binding agent while generating chloromethyl isopropyl carbonate acid salt, and then remove the hydrochloride of the acid-binding agent by centrifugation or washing, and then obtain the finished product through rectification, and then add alkali to recover the acid-binding agent. Because of the use of acid-binding agents, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C68/02C07C68/08C07C69/96
CPCC07C68/02C07C68/08C07C69/96
Inventor 韩扶军孙晟中白深科马骅
Owner INNER MONGOLIA SAINTCHEM CHEM
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