Production method of 3D printed artificial bone

A 3D printing and 3D printer technology, applied in the medical field, can solve the problems of drugs staying in the parts that need to play a role, unable to meet the requirements of orthopaedic surgery, and increasing bone mass. It can achieve step-by-step medication, increase bone mass, and prolong sustained release. effect of time

Inactive Publication Date: 2018-03-23
迈海新型材料科技(固安)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The embodiment of the present application provides a manufacturing method of 3D printing artificial bone, which solves the problem that the prior art cannot meet the requirements of various types of orthopedic surgery due to the absence of a bone window closure system, and at the same time, due to the lack of a bone window closure system, makes The technical problem of drug outflow and the inability to keep the drug in the place where it needs to play a role has been achieved. According to 3D printing, the structure of the artificial bone and the bone window is consistent, which is conducive to the sealing of the drug and will not allow the drug to flow out. At the same time, it can increase the bone mass in the later stage. Effect

Method used

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  • Production method of 3D printed artificial bone
  • Production method of 3D printed artificial bone
  • Production method of 3D printed artificial bone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] figure 1 It is a schematic flowchart of a manufacturing method of 3D printing artificial bone provided in the embodiment of the present application. Such as figure 1 As shown, the method includes:

[0031] Step 101: Obtain 3D graphics through 3D CT;

[0032] Specifically, by performing a three-dimensional CT on the affected part of the patient, a 3D stereoscopic image of the affected part can be obtained, and the above-mentioned 3D stereographic image can truly see the shape of the bones of the affected part. For example, a patient suffers from a bone tumor. After surgery to remove the bone tumor, there will be a gap in the affected bone. The gap depends on the size and shape of the bone tumor. It is not the same. Therefore, through 3D CT, a figure with the same shape and size as the patient's bone gap can be obtained.

[0033] Step 102: Obtain a 3D model of the closed bone window through modeling technology according to the 3D graphics;

[0034] Specifically, acco...

Embodiment 2

[0052] In order to realize the use of more sensitive drugs and further improve the sustained-release effect, the embodiment of the present application also provides a manufacturing method of 3D printing artificial bone, such as figure 2 As shown, the method includes:

[0053] Step 210: Obtain the third sensitive drug;

[0054] Step 220: Obtain a fourth sensitive drug, wherein the sensitivity of the second sensitive drug is lower than that of the third sensitive drug, and the sensitivity of the third sensitive drug is lower than that of the fourth sensitive drug drug;

[0055] Specifically, step 210 and step 220 can refer to the explanation of step 110 and step 120, the sensitivity of the second sensitive drug is lower than that of the third sensitive drug, and the sensitivity of the third sensitive drug Lower than the fourth sensitive drug.

[0056] Step 230: Dissolving the third sensitive drug in the solvent to make a third suspension;

[0057] Step 240: configuring the ...

Embodiment 3

[0065] In order to realize the use of more moderately sensitive drugs and further improve the sustained release effect, the embodiment of this application also provides a manufacturing method of 3D printed artificial bone, please refer to image 3 , the method includes:

[0066] Step 310: Obtain a fifth sensitive drug, wherein the sensitivity of the fifth sensitive drug is higher than that of the first sensitive drug;

[0067] Step 320: dissolving the fifth sensitive drug in the solvent, and making a fifth suspension;

[0068] Step 330: After adding the first solid substance into the fifth suspension, add the calcium-containing compound with a weight percentage of 5%-50% to form a third solid substance.

[0069] Step 340: Obtain a sixth sensitive drug, wherein the sensitivity of the sixth sensitive drug is higher than that of the fifth sensitive drug;

[0070] Step 350: Dissolving the sixth sensitive drug in the solvent to make a sixth suspension;

[0071] Step 360: After a...

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Abstract

An embodiment of the invention provides a production method of 3D printed artificial bone and relates to the technical field of medicine. The method comprises the steps as follows: a 3D graph is obtained through 3D CT; a 3D model of a closed bone window is obtained according to the 3D graph; a first sensitive drug is obtained; a second sensitive drug is obtained, and a lactic acid-acetic acid containing copolymer with the weight percentage being 0.1%-20% is dissolved with 1,4-dioxane into a solvent; the first sensitive drug is dissolved in the solvent and a first suspension is prepared; a calcium-containing compound with the weight percentage being 5%-50% is added to the first suspension and a first solid is prepared; the second sensitive drug is dissolved in the solvent and a second suspension is prepared; after the first solid is added to the second suspension, a calcium-containing compound with the weight percentage being 5%-30% is added to serve as a raw material, and a first pastymaterial is prepared; the first pasty material is added to a 3D printer for printing and first artificial bone is formed. The technical problem that drugs cannot be kept at affected parts in the prior art is solved, and the technical effects of drug closing and increase of later can be realized.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a method for manufacturing 3D printed artificial bones. Background technique [0002] Osteomyelitis is an infection and destruction of bone caused by aerobic or anaerobic bacteria, mycobacteria and fungi. In the treatment of osteomyelitis, it is often necessary to penetrate the bone injury site and fill it with bone cement and other substances. [0003] However, in the process of realizing the technical solution of the invention in the embodiment of the present application, the inventor of the present application found that the above-mentioned technology has at least the following technical problems: [0004] In the prior art, in the clinical treatment of osteomyelitis, there are often methods of bone removal and bone window opening. The slow-release drugs currently used in clinical practice have a single shape and simple structure, and do not involve a window-opening and seali...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/18A61L27/50A61L27/54B33Y10/00B33Y50/00B33Y70/00B33Y80/00
CPCA61L27/18A61L27/12A61L27/50A61L27/54A61L2300/406A61L2300/45A61L2300/602A61L2430/02B33Y10/00B33Y50/00B33Y70/00B33Y80/00C08L67/04
Inventor 李征宇曾庆丰
Owner 迈海新型材料科技(固安)有限公司
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