Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for preparing silodosin chiral intermediate

A technology of intermediates and synthetic methods, applied in the field of drug synthesis, can solve the problems of chiral resolution waste, expensive raw materials, and low yield of follow-up reactions, etc., and achieve the effects of low product cost, simple reaction operation, and high application value

Inactive Publication Date: 2018-03-30
SUN YAT SEN UNIV
View PDF5 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reaction raw materials of this route are not easy to obtain, the subsequent reaction yield is not high, and it is difficult to realize industrial production
[0007] In summary, the existing synthesis process has the disadvantages of expensive and difficult to obtain raw materials and auxiliary materials, or the need for chiral resolution to cause waste, etc. Therefore, the development of a new process for the synthesis of compound A with high efficiency and low cost has high application value

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparing silodosin chiral intermediate
  • Method for preparing silodosin chiral intermediate
  • Method for preparing silodosin chiral intermediate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025]

[0026] Take a three-necked reaction flask to vacuum and then fill it with nitrogen, repeat three times, add 34.6g (100mmol) of 1-[3-(benzyloxy)propyl]-5-bromoindoline and 200mL tetrahydrofuran. At -78°C, 50 mL (2.4 M, 120 mmol) of a n-butyllithium solution in n-hexane was slowly added dropwise, and stirring was continued for 15 minutes after the addition was complete. Take 31.9 g (120 mmol) of (R)-N-benzyloxycarbonyl-alanine Weinreb amide, dissolve it in 200 mL of tetrahydrofuran, and slowly add it dropwise to the above reaction solution at -78°C. Slowly warm to room temperature and stir overnight. Slowly add 400 mL of saturated ammonium chloride solution under ice bath, stir for 30 minutes, and transfer to a separatory funnel. Extracted with ethyl acetate (300 mL×3), the combined organic layer was washed twice with 400 mL saturated brine, and then dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure, and the residue was purified by...

Embodiment 2

[0028] Using the same procedure as in Example 1, 92.3 mL of sec-butyl lithium (120 mmol, 1.3 M cyclohexane solution) was used instead of n-butyl lithium to obtain 30.0 g of the product with a yield of 63.6% and an ee value of 99.9%.

Embodiment 3

[0030] Using the same procedure as in Example 1, 92.3mL of tert-butyllithium (120mmol, 1.3M pentane solution) was used instead of n-butyllithium to obtain 26.6g of the product with a yield of 56.3% and an ee value of 99.9%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention provides a method for synthesizing a silodosin intermediate with a high enantiomeric purity. The method comprises the steps of using 1-[3-(benzyloxy)propyl]-5-bromoindoline as the raw material, performing a bromine lithium exchange reaction with an organolithium reagent to obtain 1-[3-(benzyloxy)propyl]-5-lithiumindoline, performing a Weinreb amidization reaction with (R)-N-(alkoxycarbonyl)alanine to obtain the silodosin intermediate with a good yield and enantioselectivity. The method has the advantages of simple operation, cheap and easily-available raw materials, highenantiomeric purity of the product and no resolution step, and has extremely high application value for industrial preparation of silodosin.

Description

technical field [0001] The present invention relates to a 1A - A new method for preparing a chiral intermediate of the adrenergic receptor antagonist silodosin, which belongs to the field of drug synthesis. Background technique [0002] Silodosin (Silodosin), the chemical name is 2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[2-[2-(2,2,2- Trifluoroethoxy)phenoxy]ethylamino]propyl]-1H-indole-7-carboxamide, is a novel highly selective α 1A - Adrenergic receptor antagonists, which have a good therapeutic effect on dysuria caused by benign prostatic hyperplasia in men. [0003] [0004] At present, most of the production of silodosin firstly prepares compound A, and then prepares silodosin through several subsequent steps. There are many reports about the synthetic method of compound A, mainly containing the following: [0005] [0006] Japanese patent JP200119956 discloses a method for preparing compound A by asymmetric reductive amination of 3-(1-(3-(benzyloxy)propyl)-7-...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D209/08
CPCC07D209/08
Inventor 鄢明黄桐堃吴良玉
Owner SUN YAT SEN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com