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Preparation method and application of molecular imprinted sensor with SERS (Surface Enhanced Raman Scattering) activity

A technology of molecular imprinting and sensors, which is applied in the field of preparing molecular imprinting sensors with SERS activity to detect pyrethroids, can solve the problems of ignoring the complexity of components, achieve stable physical and chemical properties, high detection sensitivity, and broaden the application field.

Inactive Publication Date: 2018-03-30
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the current SERS studies focus on the morphology design, ignoring the complexity of the actual sample composition

Method used

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  • Preparation method and application of molecular imprinted sensor with SERS (Surface Enhanced Raman Scattering) activity
  • Preparation method and application of molecular imprinted sensor with SERS (Surface Enhanced Raman Scattering) activity
  • Preparation method and application of molecular imprinted sensor with SERS (Surface Enhanced Raman Scattering) activity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Preparation of Ag nanoparticles with different shapes

[0037] In a 50mL single-necked flask, 1.0mL of 1.0mol L -1 AgNO 3 solution and 0.25mol L -1 The acid solution (citric acid and mandelic acid) was added to 9.0mL deionized water under stirring conditions, and 1.0mL of 1.0mol L -1 VC, continue stirring. After the reaction, it was repeatedly washed, centrifuged, and dried for later use.

[0038] (2) Preparation of Molecularly Imprinted Sensors of Ag-MIPs

[0039] In a 100mL single-necked flask, 1.0g of Ag nanoparticles with different morphologies were dispersed into a mixed solution of 40mL toluene and 1.0mL MPS, and a sufficient amount of N 2 To exclude oxygen in the solution; after 9.0 hours, the synthesized product was centrifuged, washed with ethanol three times, and dried in vacuum to obtain solid A for use.

[0040] Disperse 100mg of solid A into 50mL of acetonitrile, sonicate thoroughly, then add 0.1mmol LC, 0.3mmol AM and 1.0mmol EGDMA into the solut...

Embodiment 2

[0045] (1) Preparation of Ag nanoparticles with different shapes

[0046] In a 50mL single-necked flask, 1.0mL of 1.0mol L -1 AgNO 3 solution and 0.25mol L -1 The acid solution (citric acid and mandelic acid) was added to 10mL deionized water under stirring conditions, and 1.0mL 1.0mol L -1 VC, continue stirring. After the reaction, it was repeatedly washed, centrifuged, and dried for later use.

[0047] (2) Preparation of Molecularly Imprinted Sensors of Ag-MIPs

[0048] In a 100mL single-necked flask, 1.0g of Ag nanoparticles with different morphologies was dispersed into a mixed solution of 50mL toluene and 2.0mL MPS, passing a sufficient amount of N 2 To exclude oxygen in the solution; after 10 hours, the synthesized product was centrifuged, washed three times with ethanol, and dried in vacuum to obtain solid A for use.

[0049] Disperse 100mg of solid A into 60mL of acetonitrile, sonicate thoroughly, then add 0.2mmol LC, 0.4mmol AM and 1.2mmol EGDMA into the solutio...

Embodiment 3

[0054] (1) Preparation of Ag nanoparticles with different shapes

[0055] In a 50mL single-necked flask, 1.0mL of 1.0mol L -1 AgNO 3 solution and 0.25mol L -1 The acid solution (citric acid and mandelic acid) was added to 11mL of deionized water with stirring, and 1.0mL of 1.0mol L -1 VC, continue stirring. After the reaction, it was repeatedly washed, centrifuged, and dried for later use.

[0056] (2) Preparation of Molecularly Imprinted Sensors of Ag-MIPs

[0057] In a 100mL single-necked flask, 1.0g of Ag nanoparticles with different shapes were dispersed into a mixed solution of 60mL toluene and 3.0mL MPS, and a sufficient amount of N 2 To exclude oxygen in the solution; after 11 hours, the synthesized product was centrifuged, washed with ethanol three times, and dried in vacuum to obtain solid A for use.

[0058] Disperse 100 mg of solid A into 70 mL of acetonitrile, sonicate thoroughly, then add 0.3 mmol LC, 0.5 mmol AM and 3.0 mmol EGDMA into the solution, pass N ...

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Abstract

The invention provides a preparation method and application of a molecular imprinted sensor with a silver nanoparticle active substrate, and belongs to the technical field of preparation of functional materials. The preparation method comprises the following steps: step one, preparing Ag nanoparticles with different morphologies; step two, preparing an Ag-MIPs molecular imprinted sensor with thesilver nanoparticle active substrate. According to the preparation method and the application disclosed by the invention, by combining a Raman detection technology with a molecular imprinting technology, a product has sensitive detectability and high selectivity. The invention relates to a novel self-assembly method: the molecular imprinted sensor with the active substrate modified by silver nanoparticles is prepared by using a small amount of acid and a novel method is provided for detecting residual pyrethroid pesticide in river water.

Description

technical field [0001] The invention relates to a technique for preparing a molecular imprinted sensor with SERS activity for detecting pyrethroids, and belongs to the technical field of functional material preparation. Background technique [0002] Pyrethroid pesticides have many advantages, such as good stability, strong insecticidal activity, easy degradation, low environmental persistence and toxicity. Therefore, it is widely used as an insecticide all over the world. However, the excessive use of pyrethroid pesticides has caused serious risks and threats to animals and humans, and it can be transferred to human bodies through contaminated vegetables and fruits and drinking water. Some investigations have shown that excessive accumulation of pyrethroid pesticides in humans can cause cancer, immune system and respiratory system diseases. Acceptable limits for pesticides vary from country to country, but generally range from 0.1 to 50 μg / g. Therefore, it is urgent to fi...

Claims

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Application Information

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IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 李洪吉王笑楠王梓润王焱李春香
Owner JIANGSU UNIV
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