Cannabinoid receptor agonist for treating inflammation and synthetic method of cannabinoid receptor agonist
A cannabinoid receptor and synthesis method technology, applied in the directions of anti-inflammatory agents, drug combinations, non-central analgesics, etc., to achieve the effects of easy purchase of raw materials, short production cycle, and simple operation
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[0027] The synthetic conditions of 4-(4-methyl-1-naphthylcarboxamide) methyl nicotinate 2 are:
[0028] Mix 4-aminonicotinic acid methyl ester 1 (22 g), 4-methyl-1-naphthoic acid (70 g), triethylamine (44 g), DMAP (7 g), and dichloromethane (120 mL) , stirred at 20 - 80 °C for 12 - 20 hours; added toluene (150 mL) to the system, stirred for 2 - 5 hours, and filtered to obtain methyl 4-(4-methyl-1-naphthylcarboxamide) nicotinate 2 (34g).
[0029] 1 H NMR (400 MHz, DMSO- d6 ) δ = 2.77 (s, 3H), 4.00 (s, 3H), 7.42 (d,1H), 7.55−7.66 (m, 3H), 7.80 (d, 1H), 8.03−8.14 (m, 1H), 8.49 (dd, 1H), 8.53−8.6 (m, 1H), 9.42 (dd, 1H), 11.59 (s, 1H) ppm; m / z (MS-ESI): 321.35 [M + 1] + .
[0030] The synthetic conditions of 4-(4-bromomethyl-1-naphthylcarboxamide) methyl nicotinate 3 are:
[0031] Methyl 4-(4-methyl-1-naphthylcarboxamide) nicotinate 2 (26 g), N - Bromosuccinimide (22 g), benzoyl peroxide (10 g) and chloroform (60 mL) were mixed, stirred at 60 - 120 °C for 1 - 4 hours; cooled...
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