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Composite bone cement capable of forming pores and increasing the holding ability of bone, preparation method and applications thereof

A technology of bone cement and pore formation, which is applied in medical science, tissue regeneration, prosthesis, etc., and can solve the problems of limited effect, ineffective effect, poor effect, etc.

Pending Publication Date: 2018-04-13
PEKING UNIV THIRD HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of CPC on enhancing the screw holding force is poor, especially the effect of immediately enhancing the holding force is not obvious. It only increases the screw pull-out force by about 80% (417N VS 243N), and has no anti-rotation and shear resistance. Clinically, it can only be used to enhance the stability of non-load-bearing bone screws, but its role in the majority of fractures caused by load-bearing bone osteoporosis is greatly limited

Method used

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  • Composite bone cement capable of forming pores and increasing the holding ability of bone, preparation method and applications thereof
  • Composite bone cement capable of forming pores and increasing the holding ability of bone, preparation method and applications thereof
  • Composite bone cement capable of forming pores and increasing the holding ability of bone, preparation method and applications thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Preparation and characterization of bone cement C1 containing 50% β-tricalcium phosphate (TCP) in solid phase and 5% HEMA in liquid phase

[0054] 1. Prepare the mixing system for forming composite bone cement C1:

[0055] 1) Prepare the solid phase components in the system: mix 5g of PMMA powder currently used clinically (Tianjin Synthetic Materials Industry Research Co., Ltd.) and 5g of TCP powder (β-tricalcium phosphate, Nanjing Epurui Nano Materials Co., Ltd. company) were mixed and loaded into a ball mill jar, and mixed at a low speed for 30 minutes to obtain a solid phase component.

[0056] 2) Prepare the liquid phase components in the system: Methyl methacrylate with a mass fraction of 94.55%, HEMA with a mass fraction of 5%, and DMPT with a mass fraction of 0.45% are mixed to prepare a liquid phase component.

[0057] 2. Preparation of composite bone cement C1:

[0058] Weigh 8g of the solid phase component into a 20ml syringe, add the liquid phase component,...

Embodiment 2

[0066] Preparation and characterization of bone cement C2 containing 50% β-tricalcium phosphate (TCP) in solid phase and 10% HEMA in liquid phase

[0067] 1. Prepare the mixing system for forming composite bone cement C2:

[0068] 1) Prepare the solid phase components in the system: mix 5g of PMMA powder currently used clinically (Tianjin Synthetic Materials Industry Research Co., Ltd.) and 5g of TCP powder (β-tricalcium phosphate, Nanjing Epurui Nano Materials Co., Ltd. company) were mixed and loaded into a ball mill jar, and mixed at a low speed for 30 minutes to obtain a solid phase component.

[0069] 2) Prepare the liquid phase components in the system: 89.55% methyl methacrylate and 10% HEMA are mixed with 0.45% DMPT to prepare the liquid phase components.

[0070] 2. Preparation of composite bone cement C2:

[0071] Weigh 8g of the solid phase component into a 20ml syringe, add the liquid phase component, control the solid-liquid ratio to 2:1 (g / mL), stir well for 1mi...

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Abstract

The invention discloses composite bone cement capable of forming pores and increasing the holding ability of bone, wherein the pre-preparation system of the bone cement comprises a solid phase component and a liquid phase component, the solid phase component comprises polymethacrylate and calcium phosphate as a pore forming agent, and the liquid phase component comprises hydroxyethyl methacrylate.According to the present invention, with the application of the bone cement in human body, the holding ability of bone can be increased at the early stage, and the pores can be formed along with thecalcium phosphate absorption by the human body at the late stage so as to promote the bone ingrowth, such that the binding strength of the bone cement-cancellous bone interface can be enhanced, and the late failure rate of the internal fixation can be reduced; and the composite bone cement has advantages f excellent injectability, excellent mechanical property, excellent curing rate and no toxicity, and can be used clinically as soon as possible.

Description

technical field [0001] The invention belongs to the field of bone cement materials, and in particular relates to a composite bone cement capable of forming holes and increasing the holding force of bones, as well as its preparation method and application. Background technique [0002] As the aging population continues to intensify, fractures caused by osteoporosis have become a difficult problem for researchers and clinicians to face. According to EU statistics in 2013, there are 3.5 million new fractures caused by osteoporosis in the EU every year, and medical expenses are about 37 billion euros. According to relevant research in my country, the rate of osteoporosis in my country has been increasing at an annual rate of 15% in the past 10 years. In 2016, the incidence of osteoporosis in people over 40 years old was 24.6%, and there were about 140 million people suffering from it. Fractures caused by osteoporosis often require surgical treatment. The main problems encounter...

Claims

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Application Information

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IPC IPC(8): A61L27/16A61L27/12A61L27/00A61L27/50A61L27/56
CPCA61L27/00A61L27/12A61L27/16A61L27/50A61L27/56A61L2430/02C08L33/10
Inventor 周方邱东吕扬高山李爱玲
Owner PEKING UNIV THIRD HOSPITAL
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