Cosmetic composition for inhibiting pruritus and alleviating atopic dermatitis, containing isosecotanapartholide as active ingredient

A cosmetic composition and technology for atopic dermatitis, applied in the field of cosmetic compositions for pruritus suppression and atopic dermatitis improvement, can solve problems such as product disappearance, and achieve excellent pruritus inhibition effect, inhibition and relieving effects of pruritus

Inactive Publication Date: 2018-04-17
SK BIOLAND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] Currently, many domestic universities and bio-enterprise research groups are researching and commercializing improvement agents for improving atopic dermatitis, but most of the developed products disappear in the early stages of market entry

Method used

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  • Cosmetic composition for inhibiting pruritus and alleviating atopic dermatitis, containing isosecotanapartholide as active ingredient
  • Cosmetic composition for inhibiting pruritus and alleviating atopic dermatitis, containing isosecotanapartholide as active ingredient
  • Cosmetic composition for inhibiting pruritus and alleviating atopic dermatitis, containing isosecotanapartholide as active ingredient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Example 1: Manufacturing of ISTP

[0072] The compound ISTP was isolated from Artemisia princeps by the following method.

[0073] First, dry the wormwood purchased from the Jingdong market, and then add 50L of 95% ethanol to 5kg of the finely cut whole plant, and repeat the extraction three times at room temperature for more than three days, and then use the filtrate obtained by filtration to reduce pressure A concentrator (EYELA company, N-1000, Japan) performs vacuum concentration to produce a crude extract. After 200 g of the prepared crude extract was suspended in 2L of distilled water, the same amount of ethyl acetate was added to perform 6 repeated extractions, and the ethyl acetate layer was recovered by fractionation with a separatory funnel, and then the ethyl acetate layer was reduced. 70 g of the ethyl acetate soluble extract of mugwort was obtained by pressure concentration.

[0074] After dissolving the obtained ethyl acetate soluble extract of mugwort leaves ...

reference example 1

[0082] Reference example 1: purity analysis of ISTP

[0083] In order to understand the purity of the ISTP obtained in Example 1, a purity analysis was performed using high performance liquid chromatography (HPLC) under the conditions described in Table 2 and the results are shown in Table 3.

[0084] 【table 3】

[0085] Test substance

[0086] The analysis results are shown in Table 3, and the refined product of Example 1 was refined at a content of 99.9% relative to the area of ​​the high performance liquid chromatography.

Embodiment 2

[0087] Example 2: Production of purified ISTP 0.05% solution

[0088] In order to contain 0.05% by weight of the compound ISTP obtained in Example 1, the mixture of pure water and butanediol (30% by weight) was stirred for one hour at room temperature for dissolution, and then used Whatman #5 filter paper Filtration was performed to produce a solution of 0.05% by weight of ISTP. In addition, the high performance liquid chromatography (HPLC) analysis result of ISTP 0.05% solution is as follows figure 2 .

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PUM

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Abstract

The present invention relates to a cosmetic composition for inhibiting and relieving pruritus or alleviating atopic dermatitis, containing, as an active ingredient, isosecotanapartholide represented by chemical formula [1] below. According to the present invention, the cosmetic composition containing isosecotanapartholide is very safe since cytotoxicity has not been observed, is capable of inhibiting and relieving pruritus by inhibiting interleukin-31 (IL-31) or interleukin-33 (IL-33) among cytokines causing various types of pruritus, has an excellent ability of inhibiting a thymic stromal lymphopoietin (TSLP) cytokine, which is the top-level protein in abnormal signaling caused by an immune imbalance, which is the fundamental cause of atopic dermatitis, and has an excellent ability of inhibiting the expression of MDC and TARC chemokines in HaCaT cells, and thus the cosmetic composition can alleviate atopic skin.

Description

Technical field [0001] The present invention relates to a cosmetic composition for inhibiting pruritus and ameliorating atopic dermatitis, and more specifically, to a cosmetic composition containing an active ingredient ISTP (Isosecotanapartholide) for inhibiting pruritus and improving atopic dermatitis. Background technique [0002] Pruritus is a sensation caused by many skin diseases, mainly related to atopic dermatitis, contact dermatitis, rash, prurigo nodular, scabies, chronic lichen simplex, insect bites, nummular eczema and other diseases. This kind of pruritus is caused by irritation of the skin nerves. If you scratch or rub too much in order to eliminate the pruritus, erythema, cracks, ulcers, wind masses, pigmentation, etc. will appear. If it continues, the skin will thicken. (Greaves et al, The Lancet., 348, pp.938-40, 1996) [0003] Pruritus has two clinical meanings. One is hyperknesis caused by allergic itch (hyperknesis), which does not cause pruritus under very wea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61K8/9789A61Q19/00A61P17/04
CPCA61K8/4973A61K8/97A61Q19/00A61K8/49A61K8/02A61K8/9789A61P17/04
Inventor 韩昌成金镇国李康赫金键勇朴素延张準桓尹智园
Owner SK BIOLAND CO LTD
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