Cosmetic composition for inhibiting pruritus and alleviating atopic dermatitis, containing isosecotanapartholide as active ingredient
A cosmetic composition and technology for atopic dermatitis, applied in the field of cosmetic compositions for pruritus suppression and atopic dermatitis improvement, can solve problems such as product disappearance, and achieve excellent pruritus inhibition effect, inhibition and relieving effects of pruritus
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Embodiment 1
[0071] Example 1: Manufacturing of ISTP
[0072] The compound ISTP was isolated from Artemisia princeps by the following method.
[0073] First, dry the wormwood purchased from the Jingdong market, and then add 50L of 95% ethanol to 5kg of the finely cut whole plant, and repeat the extraction three times at room temperature for more than three days, and then use the filtrate obtained by filtration to reduce pressure A concentrator (EYELA company, N-1000, Japan) performs vacuum concentration to produce a crude extract. After 200 g of the prepared crude extract was suspended in 2L of distilled water, the same amount of ethyl acetate was added to perform 6 repeated extractions, and the ethyl acetate layer was recovered by fractionation with a separatory funnel, and then the ethyl acetate layer was reduced. 70 g of the ethyl acetate soluble extract of mugwort was obtained by pressure concentration.
[0074] After dissolving the obtained ethyl acetate soluble extract of mugwort leaves ...
reference example 1
[0082] Reference example 1: purity analysis of ISTP
[0083] In order to understand the purity of the ISTP obtained in Example 1, a purity analysis was performed using high performance liquid chromatography (HPLC) under the conditions described in Table 2 and the results are shown in Table 3.
[0084] 【table 3】
[0085] Test substance
[0086] The analysis results are shown in Table 3, and the refined product of Example 1 was refined at a content of 99.9% relative to the area of the high performance liquid chromatography.
Embodiment 2
[0087] Example 2: Production of purified ISTP 0.05% solution
[0088] In order to contain 0.05% by weight of the compound ISTP obtained in Example 1, the mixture of pure water and butanediol (30% by weight) was stirred for one hour at room temperature for dissolution, and then used Whatman #5 filter paper Filtration was performed to produce a solution of 0.05% by weight of ISTP. In addition, the high performance liquid chromatography (HPLC) analysis result of ISTP 0.05% solution is as follows figure 2 .
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