Method for preparing calcium alginate nerve conduit and nerve scaffold

A nerve conduit and sodium alginate technology, applied in the field of biomedicine, can solve the problem of no pore size description, achieve low raw material cost, simple operation, and promote the effect of repairing peripheral nerve defects

Inactive Publication Date: 2018-04-20
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the invention does not further describe its pore size

Method used

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  • Method for preparing calcium alginate nerve conduit and nerve scaffold
  • Method for preparing calcium alginate nerve conduit and nerve scaffold
  • Method for preparing calcium alginate nerve conduit and nerve scaffold

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Influence of the pores in the nerve conduit (NC) wall on its ability to promote the repair of peripheral nerve defects

[0077] 1) Preparation of shell powder with gradient particle size

[0078] Rinse the shell of Anodonta dorsalis with clean water, and dry it. The structure is shown in figure 2 . The superficial layers of the exfoliated layer and the nacre layer were polished separately, and the remaining part was regarded as the prismatic layer, which was used as a material for subsequent research. Mechanically pulverize and sieve (n mesh) for later use. Select a standard sieve according to Table 1 to prepare shell powder with a particle size ranging from 25 to 150 μm.

[0079] Table 1 Imperial Standard Sieve / Particle Size / Expected Pore Comparison Table

[0080] British standard sieve (mesh)

100

150

200

240

300

350

400

500

Particle size (μm)

150

105

75

63

53

45

37

25

Expected porosity (μm)

...

Embodiment 2

[0101] Effects of microchannels inside artificial nerves on its effect on promoting the repair of peripheral nerve defects

[0102] 1) Preparation of a cylinder (AS) with microchannels inside

[0103] use Figure 4 device to prepare microchannels. That is, prepare two disks ( Figure 4 a), 80 grooves with a width of 1.5mm are arranged radially on it ( Figure 4 d), 100 circular holes with a diameter of 1mm are distributed on each groove ( Figure 4 e). These 2 disks are fixed against each other, and the two are spaced 1m apart. According to the number of microchannels in Table 2, n silks are arranged on the disk in parallel and evenly (n=microchannel quantity) ( Figure 4 c). In the middle of the fiber, two rings ( Figure 4 b) Limit the outer diameter of the tow in between to 18mm. Install a tubular mold with an inner diameter of 18mm, add sodium alginate shell powder colloid to it, dry it naturally, and place it in two rings ( Figure 4 b) Cut the silk at a position...

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Abstract

The invention belongs to the field of biomedicine, and particularly relates to a method for preparing a calcium alginate nerve conduit and nerve scaffold. Raw materials include shell powder and sodiumalginate. The shell matrix/calcium alginate nerve conduit is prepared by treating a mixture of shell powder and sodium alginate with hydrochloric acid. The nerve scaffold is obtained by filling the middle of the nerve conduit with a cylinder containing microchannels, and the microchannels are prepared through biofilaments. The preparation method can be used for preparing a nerve conduit with pores of different sizes in the wall and a nerve scaffold containing microchannels of different diameters and numbers. The nerve conduit and nerve scaffold can be used for preparing a model for evaluatingthe repair effect of peripheral nerve defects, thereby providing a reference basis for the design of artificial neural structures and achieving a better effect of promoting repair of peripheral nervedefects.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a preparation method of a nerve guide and a nerve support. Background technique [0002] Peripheral nerve injury is a common disease in clinical work. For different injury sites and degrees, end-to-end anastomosis of epineurium, perineurium and nerve transplantation can be used to repair. For peripheral nerve defects, nerve transplantation is required. Autologous nerve transplantation is the "gold standard", but it will cause complications in the donor site. Therefore, people are committed to the research of artificial nerve (ANG), in order to eventually replace autologous nerve grafts with artificial nerves. Generally, people are accustomed to call the hollow artificial nerve with a tubular structure the nerve guide (NC), and the filler inside the nerve guide as the nerve stent (NS). [0003] At present, there are many types of artificial nerves reported in the research, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/20A61L27/56
CPCA61L27/20A61L27/3604A61L27/56A61L2430/32C08L5/04
Inventor 刘彬张娇张选杰张子腾
Owner SOUTHWEST UNIVERSITY
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