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A kind of low molecular weight polyvinyl alcohol self-healing hydrogel and preparation method thereof

A technology of polyvinyl alcohol and low molecular weight, which is applied in the field of polymer biomaterials, can solve the problems of application limitation, limited application, toxicity of complex chemical modification process, etc., and achieve the effect of convenient operation, simple route and excellent biocompatibility

Active Publication Date: 2021-03-30
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, high concentration (>25wt%) and high molecular weight (>100kDa) PVA is required as a raw material for the preparation of self-healing hydrogels by this method, which limits the application of this method in the field of biomaterials.
The host-guest recognition based on cucurbituril has also been widely used in PVA supramolecular self-healing hydrogels, but its application is limited due to the complex chemical modification process of cucurbituril and its potential toxicity.

Method used

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  • A kind of low molecular weight polyvinyl alcohol self-healing hydrogel and preparation method thereof
  • A kind of low molecular weight polyvinyl alcohol self-healing hydrogel and preparation method thereof
  • A kind of low molecular weight polyvinyl alcohol self-healing hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Preparation of carboxylic acid modified PVA: 4.0g PVA (average Mw: 13000-23000) was dissolved in 20mL dimethylsulfoxide (DMSO) at 80°C, 455mg succinic anhydride (equivalent to PVA hydroxyl molar weight 5%) and 13 mg of p-toluenesulfonic acid (5% of the molar weight of succinic anhydride) were added to the PVA solution as catalysts. The reaction was stirred at 50°C for 48 hours. After the reaction, it was precipitated with ether, and the precipitate was redissolved in an appropriate amount of water, dialyzed for 5 days, and freeze-dried to obtain carboxylic acid-modified PVA.

[0037] (2) Preparation of polyvinyl alcohol PVA-CA grafted with cholic acid: 500 mg of carboxylic acid-modified PVA was dissolved in 10 mL of dimethylformamide (DMF) at 80 ° C, and then 96 mg of amino-modified cholic acid ( cholic acid to anhydride group molar ratio 0.4:1), 53 mg EDC (EDC to cholic acid molar ratio 1.3:1) and 5 mg HOBt (HOBt to cholic acid molar ratio 0.15:1). The mixture wa...

Embodiment 2

[0044] (1) Preparation of carboxylic acid modified PVA: 4.0g PVA (average Mw: 13000-23000) was dissolved in 20mL dimethylsulfoxide (DMSO) at 80°C, 455mg succinic anhydride (equivalent to PVA hydroxyl molar weight 5%) and 7.8 mg of p-toluenesulfonic acid (3% of the molar weight of succinic anhydride) were added as catalysts to the PVA solution. The reaction was stirred at 60°C for 36 hours. After the reaction, it was precipitated with ether, and the precipitate was redissolved in an appropriate amount of water, dialyzed for 5 days, and freeze-dried to obtain carboxylic acid-modified PVA.

[0045] (2) Preparation of polyvinyl alcohol PVA-CA grafted with cholic acid: 500 mg of carboxylic acid-modified PVA was dissolved in 10 mL of dimethylformamide (DMF) at 80 ° C, and then 48 mg of amino-modified cholic acid ( cholic acid to anhydride group molar ratio 0.2:1), 40.8 mg EDC (EDC to cholic acid molar ratio 2:1) and 3.3 mg HOBt (HOBt to cholic acid molar ratio 0.2:1). The mixture ...

Embodiment 3

[0049] (1) Preparation of carboxylic acid modified PVA: 4.0g PVA (average Mw: 13000-23000) was dissolved in 20mL dimethylsulfoxide (DMSO) at 80°C, 455mg succinic anhydride (equivalent to PVA hydroxyl molar weight 5%) and 20.8mg of p-toluenesulfonic acid (equivalent to 8% of the molar amount of succinic anhydride) were added to the PVA solution as catalysts. The reaction was stirred at 40°C for 48 hours. After the reaction, it was precipitated with ether, and the precipitate was redissolved in an appropriate amount of water, dialyzed for 5 days, and freeze-dried to obtain carboxylic acid-modified PVA.

[0050] (2) Preparation of polyvinyl alcohol PVA-CA grafted with cholic acid: 500 mg of carboxylic acid-modified PVA was dissolved in 10 mL of dimethylformamide (DMF) at 80 ° C, and then 72 mg of amino-modified cholic acid ( cholic acid to anhydride group molar ratio 0.3:1), 36.7 mg EDC (EDC to cholic acid molar ratio 1.2:1) and 2.5 mg HOBt (HOBt to cholic acid molar ratio 0.1:1...

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Abstract

The invention belongs to the technical field of polymeric biomaterials, and discloses low-molecular-weight polyvinyl alcohol self-repairing hydrogel and a preparation method thereof. The preparation method comprises the following steps: reacting low-molecular-weight polyvinyl alcohol under the conditions of succinic anhydride and p-toluenesulfonic acid to obtain carboxylic acid modified PVA; thenseparately reacting the carboxylic acid modified PVA with amino modified cholic acid and mono-(6-ethylenediamine-6-deoxy)-beta-cyclodextrin to obtain PVA-CA and PVA-CD; and finally separately dissolving PVA-CA and PVA-CD in hot water, and mixing and self-assembling the two solutions to obtain the low-molecular-weight polyvinyl alcohol self-repairing hydrogel. The obtained hydrogel has excellent biological compatibility, good mechanical property and self-repairing property. The mechanical property of the self-repairing hydrogen is regulated by regulating the grafted ratio of cholic acid, and thus, the hydrogen can adapt to biomedicines widely.

Description

technical field [0001] The invention belongs to the technical field of macromolecule biomaterials, and in particular relates to a low molecular weight polyvinyl alcohol self-repairing hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a polymer material with a three-dimensional network structure similar to biological soft tissue. It has good swelling, biocompatibility and highly adjustable mechanical properties. It is used in tissue engineering, drug carrier systems and medical devices. There are a wide range of applications in the biomedical field. In recent years, the preparation of self-healing hydrogels has become a research hotspot, and their self-healing properties are mainly based on dynamic covalent bonds or supramolecular interactions. However, most of the current research on self-healing hydrogels focuses on the development of their self-healing properties, and the problems of material toxicity and low mechanical strength have not...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L29/04C08L87/00C08F8/14C08F8/32C08F16/06C08G81/02
CPCC08F8/14C08F8/32C08G81/02C08J3/075C08J2329/04C08J2387/00C08F16/06
Inventor 贾永光任力刘卅杨军忠金家宏朱晓夏
Owner SOUTH CHINA UNIV OF TECH
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