Clinical stable eye drops

Abstract

The invention discloses clinical stable eye drops which contain the following components in parts by weight: 14.3 parts of hydrocortisone acetate, 57.1 parts of boric acid, 2.3 parts of tween-80, 0.68part of nitryl phenyl mercury, 11.4 parts of sodium carboxymethylcellulose, 2.8 parts of methylcellulose, 10.8 parts of polyhexamethylene biguanidine hydrochloride, and 0.62 part of additives. By increasing the dosage of sodium carboxymethylcellulose and adding methylcellulose, the main drug hydrocortisone acetate microcrystals are more uniformly dispersed in a suspension, and the suspension system is more stable and is unlikely to settle and layer; by adding a mixture of polyhexamethylene biguanidine hydrochloride and a quaternary ammonium compound, ethylenediamine tetraacetic acid disodiumand phenylcarbinol, the suspension is enhanced in non-corrosibility and is free of irritation. In addition, ground by a glass bead wet process, the main drug particles are finer, and are more uniformly distributed in the suspension, so that the stability of the suspension form is enhanced.

Description

technical field [0001] The invention relates to the field of eye drops, in particular to a stable clinical eye drop. Background technique [0002] Hydrocortisone acetate eye drops is currently a commonly used eye drop in clinical practice, mainly used for the treatment of acute or subacute iritis, keratitis, scleral surface inflammation and vesicular keratoconjunctivitis, etc. Combined application of drugs to treat various ocular bacterial or viral infection diseases. In the hydrocortisone acetate eye drops, the main drug hydrocortisone acetate has a small content in the preparation, and is also a hydrophobic drug, which is suspended in the state of microcrystalline particles. Due to the nature of the main drug and the suspension dosage form, it is easy to affect the quality stability of the product, such as agglomeration during storage, poor suspension, weakened antiseptic properties, and fungal growth. It not only causes poor appearance quality, but also affects the ef...

AI Technical Summary

Problems solved by technology

Due to the nature of the main drug and the suspension dosage form, it is easy to affect the quality and stability of the product, such as agglomeration during storage, poor suspension, weakened antiseptic properties, and fungal growth, etc.

Not only causes poor appearance quality, but also affects the efficacy of the drug and increases eye irritation

Images