Thermal power measurement device with Raman spectroscopy measurement function

Abstract

The invention relates to a heat power measurement device with a Raman spectrum measurement function. The measurement device comprises a heat measurement system, a Raman spectrum measurement system anda data acquisition and control system, wherein the heat measurement system is used for measuring titration heat released in a titration process; the Raman spectrum measurement system comprises a laser light source; single-color light sent by the laser light source is divided into two paths through a Y-shaped bifurcated optical fiber and the two paths of the light enter optical fiber attenuators respectively; an optical signal emitted by the first optical fiber attenuator is focused to the center of a sample reaction tank through a first optical fiber and a first optical fiber Raman probe; a Raman signal generated by a solution in the sample reaction tank is returned back to the first optical fiber Raman probe and is transmitted to an optical grating and a Raman spectrometer in sequence; similarly, an optical signal emitted by the second optical fiber attenuator is focused to a reference reaction tank through a second optical fiber and a second optical fiber Raman probe; a Raman signalgenerated by a solution in the reference reaction tank is returned back to the second optical fiber Raman probe and then is transmitted to the optical grating and the Raman spectrometer in sequence.The heat power measurement device with the Raman spectrum measurement function can be used for measuring heat power and a Raman spectrum at the same time and also can be used for independently measuring the heat power and the Raman spectrum.

Description

technical field [0001] The invention relates to a thermal power measurement device, in particular to a thermal power measurement device with Raman spectrum measurement function, and relates to the research and application of weak interactions between molecules such as biological macromolecules and molecular self-assembly and other solution reaction systems technology field. Background technique [0002] Thermal power measurement devices (ie, calorimeters) are widely used in scientific fields such as physics, chemistry, and biology, as well as technical fields such as oil recovery, chemical industry, and batteries. Among them, the isothermal titration calorimeter is especially suitable for the study of biological systems and weak interactions between molecules. Due to the complexity of this type of system, it is generally supplemented by Raman spectroscopy to obtain material structure information. Isothermal titration calorimetry can be used for multi-point continuous titra...

AI Technical Summary

Problems solved by technology

This makes it difficult to obtain a strict correspondence between the interaction and the structure of the substance by performing titration calorimetry and Raman spectroscopy respectively.

[0003] In the world, someone has combined differential scanning calorimetry and optical fiber Raman to measure the synchronous change of thermal signal and Raman signal during the temperature change process of the sample (K.P.Menard, E.L.Diz and R.Spragg: "DSC-Raman analytical system and method", United States Patent Application No.US2011 / 0170095), but for more general chemical or biological reaction processes—especially the simultaneous measurement of online thermal signals and Raman signals in solution systems, there is no instrument at home and abroad that can achieve

Images