Preparation method of nano-hydroxyapatite/cyclodextrin-based polyurethane composite porous bone tissue engineering scaffold material
A technology of nano-hydroxyapatite and tissue engineering scaffolds, which can be applied in tissue regeneration, pharmaceutical formulations, prostheses, etc. It can solve the problems of high infection risk, limited bone source, and increased patient pain, and achieves broad application prospects and low cost , The preparation method is simple and easy to implement
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Embodiment 1
[0018] Use β-cyclodextrin and hexamethylene diisocyanate to react at 70~80°C under nitrogen protection, dissolve β-cyclodextrin in 30mL dimethylformamide, stir well and add hexamethylene diisocyanate drop by drop Diisocyanate, the molar ratio of β-cyclodextrin to hexamethylene diisocyanate is 1:1~1:5, the amount of catalyst stannous octoate is 0.1%~0.2%, and 10wt% nano-hydroxyapatite is added at the same time as the catalyst (here means that the mass of nano-hydroxyapatite accounts for 10% of the total mass of reactants), the reaction continues for 4-6 hours, and after foaming with water at 90-110°C for 1-2 hours, wash with acetone To remove unreacted raw materials and low-molecular-weight substances, wash with deionized water and then dry at 37°C to obtain a 10wt% nano-hydroxyapatite / cyclodextrin-based polyurethane composite porous scaffold material.
Embodiment 2
[0020] Use β-cyclodextrin and hexamethylene diisocyanate to react at 70~80°C under nitrogen protection, dissolve β-cyclodextrin in 30mL dimethylformamide, stir well and add hexamethylene diisocyanate drop by drop Diisocyanate, the molar ratio of β-cyclodextrin to hexamethylene diisocyanate is 1:1~1:5, the amount of catalyst stannous octoate is 0.1%~0.2%, and 15wt% nano-hydroxyapatite is added at the same time as the catalyst (here means that the mass of nano-hydroxyapatite accounts for 15% of the total mass of the reactants), the reaction continues for 4-6 hours, after foaming with water at 90-110°C for 1-2 hours, wash with acetone To remove unreacted raw materials and low-molecular-weight substances, wash with deionized water and then dry at 37°C to obtain a 15wt% nano-hydroxyapatite / cyclodextrin-based polyurethane composite porous scaffold material.
Embodiment 3
[0022] Use β-cyclodextrin and hexamethylene diisocyanate to react at 70~80°C under nitrogen protection, dissolve β-cyclodextrin in 30mL dimethylformamide, stir well and add hexamethylene diisocyanate drop by drop Diisocyanate, the molar ratio of β-cyclodextrin to hexamethylene diisocyanate is 1:1~1:5, the amount of catalyst stannous octoate is 0.1%~0.2%, and 30wt% nano-hydroxyapatite is added at the same time as the catalyst (here means that the mass of nano-hydroxyapatite accounts for 30% of the total mass of reactants), the reaction continues for 4-6 hours, and after foaming with water at 90-110°C for 1-2 hours, wash with acetone To remove unreacted raw materials and low-molecular-weight substances, wash with deionized water and then dry at 37°C to obtain a 30wt% nano-hydroxyapatite / cyclodextrin-based polyurethane composite porous scaffold material.
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